Faculty Opinions recommendation of GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.

2006 ◽  
Author(s):  
Michael Schön
Keyword(s):  
Tumor Growth ◽  
G Protein ◽  
Tissue Transglutaminase ◽  
G Protein Coupled Receptor ◽  
Melanoma Tumor ◽  
Tumor Growth And Metastasis ◽  
G Protein Coupled

scholarly journals GPR56 binds tissue transglutaminase and inhibits melanoma tumor growth and metastasis

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Lei Xu ◽  
Shahinoor Begum ◽  
Jeremy D Hearn ◽  
Richard O Hynes
Keyword(s):  
Tumor Growth ◽  
Tissue Transglutaminase ◽  
Melanoma Tumor ◽  
Tumor Growth And Metastasis

G-Protein Coupled Receptor Kinase 5 Regulates Prostate Tumor Growth

2012 ◽  
Vol 187 (1) ◽  
pp. 322-329 ◽  
Author(s):  
Jae Il Kim ◽  
Prabir Chakraborty ◽  
Zhimin Wang ◽  
Yehia Daaka
Keyword(s):  
Tumor Growth ◽  
G Protein ◽  
Prostate Tumor ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals S1P2, the G Protein–Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth In vivo in Mice

2010 ◽  
Vol 70 (2) ◽  
pp. 772-781 ◽  
Author(s):  
Wa Du ◽  
Noriko Takuwa ◽  
Kazuaki Yoshioka ◽  
Yasuo Okamoto ◽  
Koichi Gonda ◽  
...  
Keyword(s):  
Tumor Growth ◽  
G Protein ◽  
Tumor Angiogenesis ◽  
G Protein Coupled Receptor ◽  
Sphingosine 1 Phosphate ◽  
G Protein Coupled

scholarly journals GPR68: An Emerging Drug Target in Cancer

2019 ◽  
Vol 20 (3) ◽  
pp. 559 ◽  
Author(s):  
Shu Z. Wiley ◽  
Krishna Sriram ◽  
Cristina Salmerón ◽  
Paul A. Insel
Keyword(s):  
Ovarian Cancer ◽  
G Protein ◽  
Drug Target ◽  
Current Knowledge ◽  
Tumor Biology ◽  
G Protein Coupled Receptor ◽  
Cellular Functions ◽  
Tumor Growth And Metastasis ◽  
G Protein Coupled ◽  
Novel Therapeutic

GPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions. Acidosis is considered a defining hallmark of the tumor microenvironment (TME). GPR68 expression is highly upregulated in numerous types of cancer. Emerging evidence has revealed that GPR68 may play crucial roles in tumor biology, including tumorigenesis, tumor growth, and metastasis. This review summarizes current knowledge regarding GPR68—its expression, regulation, signaling pathways, physiological roles, and functions it regulates in human cancers (including prostate, colon and pancreatic cancer, melanoma, medulloblastoma, and myelodysplastic syndrome). The findings provide evidence for GPR68 as a potentially novel therapeutic target but in addition, we note challenges in developing drugs that target GPR68.

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled
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