scholarly journals Influence of Maternal High Salt Diet on Systemic and Renal Renin of Newborn and Adult Male Offspring Wistar Rats

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Debora Rothstein Ramos ◽  
Nauilo Lima Costa ◽  
Ivone Braga Oliveira ◽  
Joel Claudio Heimann ◽  
Luzia Naoko S Furukawa
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
High Salt ◽  
Male Offspring ◽  
High Salt Diet ◽  
Salt Diet

scholarly journals High salt diet during pregnancy: effects on the renin ‐angiotensin‐aldosterone system in adult male offspring of Wistar rats

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Débora Rothstein Ramos ◽  
Nauilo L. Costa ◽  
Ivone B. Oliveira ◽  
Karen L. Lopes ◽  
Joel C. Heimann ◽  
...  
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
High Salt ◽  
Male Offspring ◽  
High Salt Diet ◽  
Renin Angiotensin Aldosterone System ◽  
Salt Diet ◽  
Renin Angiotensin

scholarly journals Effects of Aqueous Extract of Persea americana (Mill.) Leaf on the Myocardium of Left Ventricle of High Salt Fed Adult Wistar Rat

2018 ◽  
Vol 35 (01) ◽  
pp. 31-36
Author(s):  
I.O. Ayoola ◽  
O.A. Komolafe ◽  
O.S. Saka ◽  
R.A. Bejide ◽  
S.O.A. Odukoya
Keyword(s):  
Left Ventricle ◽  
Wistar Rats ◽  
Wistar Rat ◽  
Persea Americana ◽  
High Salt ◽  
High Salt Diet ◽  
Salt Diet ◽  
Morphological Alterations ◽  
Ketamine Anesthesia ◽  
Group B

Introduction This study was designed to show that Persea americana extract possess the ability to protect the myocardium of left ventricle against injury caused by high salt diet in adult Wistar rats. Method Forty healthy Wistar rats of both sexes weighing 120–150 g were randomly assigned into 8 groups of 5 rats each (Groups A, B, C, D, E, F, G and H). Rats in groups A, F, G and H were fed with standard laboratory pellets, while groups B, C, D and E were fed on the high-salt diet for four weeks. Concomitantly, daily administration of 50 mg kg-1, 100 mg kg-1 and 150 mg kg-1 of the Persea americana extract were given orally to groups C&F, D&G and E&H respectively while rats in groups A and B were administered distilled water. The rats were sacrificed under ketamine anesthesia (30mg/kg i.m). The left ventricle of the heart was excised, processed in paraffin wax and stained with haematoxylin and eosin and Verhoeff-Van Gieson stains. One-way ANOVA was used to analyze data, followed by Student Newman-keuls (SNK) test for multiple comparison. Result Results revealed that there was statistically significant (p < 0.05) difference in body weight change across all experimental groups; which was significantly lower in high salt fed groups. It was revealed that there were morphological alterations in the myocardium of left ventricle in group B while Persea americana protected myocardium in other experimental groups. Conclusion In conclusion, high salt diet induced myocardium alterations which were significantly protected by oral administration of Persea americana extract.

Cyperus esculentus L. (tigernut) mitigates high salt diet‐associated testicular toxicity in Wistar rats by targeting testicular steroidogenesis, oxidative stress and inflammation

Andrologia ◽  
2020 ◽  
Vol 52 (11) ◽  
Author(s):  
Justina Nwandimma Nwangwa ◽  
Augustine Lishilinimye Udefa ◽  
Ernest Atelhe Amama ◽  
Inah Onete Inah ◽  
Hamza Joseph Ibrahim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
High Salt ◽  
Testicular Toxicity ◽  
Cyperus Esculentus ◽  
High Salt Diet ◽  
Salt Diet ◽  
Testicular Steroidogenesis

The effects of high-salt diet on blood pressure and kidney and the intervention of telmisartan in Wistar rats

2011 ◽  
Vol 152 ◽  
pp. S104-S105
Author(s):  
Qianhui Shang ◽  
Xiaochun Wang ◽  
Qin Wu ◽  
Chan Liu
Keyword(s):  
Blood Pressure ◽  
Wistar Rats ◽  
High Salt ◽  
High Salt Diet ◽  
Salt Diet

scholarly journals The role of poly-herbal extract in sodium chloride-induced oxidative stress and hyperlipidemia in male Wistar rats

2021 ◽  
Author(s):  
Olumide Fadahunsi ◽  
Peter Adegbola ◽  
Olayemi Adebola Akintola ◽  
Bamidele Stephen Ajilore ◽  
olubukola sinbad Olorunnisola
Keyword(s):  
Nitric Oxide ◽  
Serum Lipid ◽  
Antioxidant Status ◽  
Wistar Rats ◽  
Density Lipoprotein ◽  
High Salt ◽  
Herbal Extract ◽  
High Salt Diet ◽  
Salt Diet ◽  
Male Wistar Rats

Abstract Consistent consumption of high salt diet (HSD) has been associated with increased cellular generation of free radicals which has been implicated in the derangement of some vital organs and etiology of cardiovascular disorders. This study was designed to investigate the combined effect of some commonly employed medicinal plants on serum lipid profile and antioxidant status of aorta, kidney, and liver of high salt diet-fed animals. Thirty-five male Wistar rats were divided into 5 groups of 7 animals each. Group 1 and 2 animals were fed normal rat and 16 % high salt diet only respectively. Animals in groups 3, 4, and 5 were fed 16% high salt diet with 800, 400, and 200 mg/kg bw poly-herbal extract (PHE) respectively once for 28 consecutive days. Serum low-density lipoprotein (LDL), triacylglycerol (TG), total cholesterol (TC) and high-density lipoprotein (HDL), malondialdehyde, nitric oxide, catalase, superoxide dismutase, glutathione peroxidase, glutathione concentration, and activities were assessed in the aorta, kidney, and liver. PHE (p < 0.05) significantly reduced malondialdehyde and nitric oxide concentration and increased antioxidant enzymes and glutathione activity. Elevated serum TG, TC, LDL, and TC content in HSD-fed animals were significantly (p < 0.05) reduced to normal in PHE-treated rats while HDL was significantly elevated (p < 0.05) in a concentration-dependent manner in PHE treated animals. Feeding with PHE attenuated high salt diet imposed derangement in serum lipid profile and antioxidant status in the organs of the experimental rats.

scholarly journals High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

2022 ◽  
Vol 15 ◽  
Author(s):  
Pedro Ernesto de Pinho Tavares Leal ◽  
Alexandre Alves da Silva ◽  
Arthur Rocha-Gomes ◽  
Tania Regina Riul ◽  
Rennan Augusto Cunha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Redox State ◽  
Redox Status ◽  
High Salt ◽  
Standard Diet ◽  
High Salt Diet ◽  
Salt Diet ◽  
Plus Maze ◽  
Male Wistar Rats

High-salt (HS) diets have recently been linked to oxidative stress in the brain, a fact that may be a precursor to behavioral changes, such as those involving anxiety-like behavior. However, to the best of our knowledge, no study has evaluated the amygdala redox status after consuming a HS diet in the pre- or postweaning periods. This study aimed to evaluate the amygdala redox status and anxiety-like behaviors in adulthood, after inclusion of HS diet in two periods: preconception, gestation, and lactation (preweaning); and only after weaning (postweaning). Initially, 18 females and 9 male Wistar rats received a standard (n = 9 females and 4 males) or a HS diet (n = 9 females and 5 males) for 120 days. After mating, females continued to receive the aforementioned diets during gestation and lactation. Weaning occurred at 21-day-old Wistar rats and the male offspring were subdivided: control-control (C-C)—offspring of standard diet fed dams who received a standard diet after weaning (n = 9–11), control-HS (C-HS)—offspring of standard diet fed dams who received a HS diet after weaning (n = 9–11), HS-C—offspring of HS diet fed dams who received a standard diet after weaning (n = 9–11), and HS-HS—offspring of HS diet fed dams who received a HS diet after weaning (n = 9–11). At adulthood, the male offspring performed the elevated plus maze and open field tests. At 152-day-old Wistar rats, the offspring were euthanized and the amygdala was removed for redox state analysis. The HS-HS group showed higher locomotion and rearing frequency in the open field test. These results indicate that this group developed hyperactivity. The C-HS group had a higher ratio of entries and time spent in the open arms of the elevated plus maze test in addition to a higher head-dipping frequency. These results suggest less anxiety-like behaviors. In the analysis of the redox state, less activity of antioxidant enzymes and higher levels of the thiobarbituric acid reactive substances (TBARS) in the amygdala were shown in the amygdala of animals that received a high-salt diet regardless of the period (pre- or postweaning). In conclusion, the high-salt diet promoted hyperactivity when administered in the pre- and postweaning periods. In animals that received only in the postweaning period, the addition of salt induced a reduction in anxiety-like behaviors. Also, regardless of the period, salt provided amygdala oxidative stress, which may be linked to the observed behaviors.

scholarly journals Biochemical Effects of Aqueous Extract of Persea americana (Mill) on the Myocardium of Left Ventricle of High Salt–Fed Adult Wistar Rats

2017 ◽  
Vol 22 (4) ◽  
pp. 765-769
Author(s):  
Ayoola I. Olushola ◽  
Komolafe O. Aderibigbe ◽  
Saka O. Stephen ◽  
Odukoya S. Ayodeji
Keyword(s):  
Nitric Oxide ◽  
Lactate Dehydrogenase ◽  
Wistar Rats ◽  
Potassium Ion ◽  
Persea Americana ◽  
High Salt ◽  
Sodium Ion ◽  
Ion Concentration ◽  
High Salt Diet ◽  
Salt Diet

Background. The cardioprotective effects of Persea americana extract was investigated on biochemical activities of high salt–fed adult Wistar rats in this study. Method. Forty healthy Wistar rats of both sexes weighing 120 to 150 g were randomly assigned into 8 groups of 5 rats each (groups A, B, C, D, E, F, G, and H). Rats in groups A, F, G, and H were fed with standard laboratory pellets, while groups B, C, D, and E were fed on the high-salt diet for 4 weeks. Concomitantly, daily administration of 50, 100, and 150 mg/kg of the P americana extract were given orally to groups C and F, D and G, and E and H, respectively, while rats in groups A and B were administered distilled water. Blood samples were taken by cardiac puncture; concentration of sodium ion, potassium ion, nitric oxide, and activity of lactate dehydrogenase were determined. One-way analysis of variance was used to analyze data, followed by Student-Newman-Keuls (SNK) test for multiple comparison. Results. Results revealed that concentration of potassium ion and nitric oxide was significantly lower ( P < .05) in high salt–fed groups. Sodium ion concentration and activity of lactate dehydrogenase were higher in high salt–fed group while P americana prevented biochemical perturbations in other experimental groups. Conclusion. In conclusion, high salt–diet induced biochemical alterations which were significantly protected by oral administration of P americana extract.

scholarly journals The Role of Poly-Herbal Extract in Sodium Chloride-Induced Oxidative Stress and Hyperlipidemia in Male Wistar Rats

Medicines ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 25
Author(s):  
Olubukola Sinbad Olorunnisola ◽  
Peter Ifeoluwa Adegbola ◽  
Bamidele Stephen Ajilore ◽  
Olayemi Adebola Akintola ◽  
Olumide Samuel Fadahunsi
Keyword(s):  
Nitric Oxide ◽  
Serum Lipid ◽  
Antioxidant Status ◽  
Wistar Rats ◽  
Density Lipoprotein ◽  
High Salt ◽  
Herbal Extract ◽  
High Salt Diet ◽  
Salt Diet ◽  
Male Wistar Rats

Consistent consumption of high salt diet (HSD) has been associated with increased cellular generation of free radicals, which has been implicated in the derangement of some vital organs and etiology of cardiovascular disorders. This study was designed to investigate the combined effect of some commonly employed medicinal plants on serum lipid profile and antioxidant status of aorta, kidney, and liver of high salt diet-fed animals. Out of the total fifty male Wistar rats obtained, fifteen were used for acute toxicity study, while the remaining thirty-five were divided into 5 groups of 7 animals each. Group 1 and 2 animals were fed normal rat chow (NRC) and 16% high salt diet (HSD) only, respectively. Animals in groups 3, 4 and 5 were fed 16% HSD with 800, 400, and 200 mg/kg bw poly-herbal extract (PHE), respectively, once for 28 consecutive days. Serum low-density lipoprotein (LDL), triacylglycerol (TG), total cholesterol (TC) and high-density lipoprotein (HDL), malondialdehyde, nitric oxide, catalase, superoxide dismutase, glutathione peroxidase, glutathione concentration, and activities were assessed in the aorta, kidney, and liver. Poly-herbal extract (p < 0.05) significantly reduced malondialdehyde and nitric oxide concentrations and also increased antioxidant enzymes and glutathione activity. Elevated serum TG, TC, LDL, and TC content in HSD-fed animals were significantly (p < 0.05) reduced to normal in PHE-treated rats while HDL was significantly elevated (p < 0.05) in a concentration-dependent manner in PHE treated animals. Feeding with PHE attenuated high-salt diet imposed derangement in serum lipid profile and antioxidant status in the organs of the experimental rats.

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