scholarly journals High salt diet during pregnancy: effects on the renin ‐angiotensin‐aldosterone system in adult male offspring of Wistar rats

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Débora Rothstein Ramos ◽  
Nauilo L. Costa ◽  
Ivone B. Oliveira ◽  
Karen L. Lopes ◽  
Joel C. Heimann ◽  
...  
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
High Salt ◽  
Male Offspring ◽  
High Salt Diet ◽  
Renin Angiotensin Aldosterone System ◽  
Salt Diet ◽  
Renin Angiotensin

scholarly journals Influence of Maternal High Salt Diet on Systemic and Renal Renin of Newborn and Adult Male Offspring Wistar Rats

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Debora Rothstein Ramos ◽  
Nauilo Lima Costa ◽  
Ivone Braga Oliveira ◽  
Joel Claudio Heimann ◽  
Luzia Naoko S Furukawa
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
High Salt ◽  
Male Offspring ◽  
High Salt Diet ◽  
Salt Diet

scholarly journals REDUCED FUNCTIONALITY OF RENIN‐ANGIOTENSIN‐ALDOSTERONE SYSTEM IN YOUNG RATS EXPOSED TO HIGH‐SALT DIET

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Sandra Crestani ◽  
Arquimedes Garparotto ◽  
Maria Consuelo Andrade Marques ◽  
Jennifer C. Sullivan ◽  
R. Clinton Webb ◽  
...  
Keyword(s):  
High Salt ◽  
High Salt Diet ◽  
Renin Angiotensin Aldosterone System ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Young Rats

scholarly journals Effects of Aqueous Extract of Persea americana (Mill.) Leaf on the Myocardium of Left Ventricle of High Salt Fed Adult Wistar Rat

2018 ◽  
Vol 35 (01) ◽  
pp. 31-36
Author(s):  
I.O. Ayoola ◽  
O.A. Komolafe ◽  
O.S. Saka ◽  
R.A. Bejide ◽  
S.O.A. Odukoya
Keyword(s):  
Left Ventricle ◽  
Wistar Rats ◽  
Wistar Rat ◽  
Persea Americana ◽  
High Salt ◽  
High Salt Diet ◽  
Salt Diet ◽  
Morphological Alterations ◽  
Ketamine Anesthesia ◽  
Group B

Introduction This study was designed to show that Persea americana extract possess the ability to protect the myocardium of left ventricle against injury caused by high salt diet in adult Wistar rats. Method Forty healthy Wistar rats of both sexes weighing 120–150 g were randomly assigned into 8 groups of 5 rats each (Groups A, B, C, D, E, F, G and H). Rats in groups A, F, G and H were fed with standard laboratory pellets, while groups B, C, D and E were fed on the high-salt diet for four weeks. Concomitantly, daily administration of 50 mg kg-1, 100 mg kg-1 and 150 mg kg-1 of the Persea americana extract were given orally to groups C&F, D&G and E&H respectively while rats in groups A and B were administered distilled water. The rats were sacrificed under ketamine anesthesia (30mg/kg i.m). The left ventricle of the heart was excised, processed in paraffin wax and stained with haematoxylin and eosin and Verhoeff-Van Gieson stains. One-way ANOVA was used to analyze data, followed by Student Newman-keuls (SNK) test for multiple comparison. Result Results revealed that there was statistically significant (p < 0.05) difference in body weight change across all experimental groups; which was significantly lower in high salt fed groups. It was revealed that there were morphological alterations in the myocardium of left ventricle in group B while Persea americana protected myocardium in other experimental groups. Conclusion In conclusion, high salt diet induced myocardium alterations which were significantly protected by oral administration of Persea americana extract.

Cyperus esculentus L. (tigernut) mitigates high salt diet‐associated testicular toxicity in Wistar rats by targeting testicular steroidogenesis, oxidative stress and inflammation

Andrologia ◽  
2020 ◽  
Vol 52 (11) ◽  
Author(s):  
Justina Nwandimma Nwangwa ◽  
Augustine Lishilinimye Udefa ◽  
Ernest Atelhe Amama ◽  
Inah Onete Inah ◽  
Hamza Joseph Ibrahim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
High Salt ◽  
Testicular Toxicity ◽  
Cyperus Esculentus ◽  
High Salt Diet ◽  
Salt Diet ◽  
Testicular Steroidogenesis

The effects of high-salt diet on blood pressure and kidney and the intervention of telmisartan in Wistar rats

2011 ◽  
Vol 152 ◽  
pp. S104-S105
Author(s):  
Qianhui Shang ◽  
Xiaochun Wang ◽  
Qin Wu ◽  
Chan Liu
Keyword(s):  
Blood Pressure ◽  
Wistar Rats ◽  
High Salt ◽  
High Salt Diet ◽  
Salt Diet

scholarly journals The role of poly-herbal extract in sodium chloride-induced oxidative stress and hyperlipidemia in male Wistar rats

2021 ◽  
Author(s):  
Olumide Fadahunsi ◽  
Peter Adegbola ◽  
Olayemi Adebola Akintola ◽  
Bamidele Stephen Ajilore ◽  
olubukola sinbad Olorunnisola
Keyword(s):  
Nitric Oxide ◽  
Serum Lipid ◽  
Antioxidant Status ◽  
Wistar Rats ◽  
Density Lipoprotein ◽  
High Salt ◽  
Herbal Extract ◽  
High Salt Diet ◽  
Salt Diet ◽  
Male Wistar Rats

Abstract Consistent consumption of high salt diet (HSD) has been associated with increased cellular generation of free radicals which has been implicated in the derangement of some vital organs and etiology of cardiovascular disorders. This study was designed to investigate the combined effect of some commonly employed medicinal plants on serum lipid profile and antioxidant status of aorta, kidney, and liver of high salt diet-fed animals. Thirty-five male Wistar rats were divided into 5 groups of 7 animals each. Group 1 and 2 animals were fed normal rat and 16 % high salt diet only respectively. Animals in groups 3, 4, and 5 were fed 16% high salt diet with 800, 400, and 200 mg/kg bw poly-herbal extract (PHE) respectively once for 28 consecutive days. Serum low-density lipoprotein (LDL), triacylglycerol (TG), total cholesterol (TC) and high-density lipoprotein (HDL), malondialdehyde, nitric oxide, catalase, superoxide dismutase, glutathione peroxidase, glutathione concentration, and activities were assessed in the aorta, kidney, and liver. PHE (p < 0.05) significantly reduced malondialdehyde and nitric oxide concentration and increased antioxidant enzymes and glutathione activity. Elevated serum TG, TC, LDL, and TC content in HSD-fed animals were significantly (p < 0.05) reduced to normal in PHE-treated rats while HDL was significantly elevated (p < 0.05) in a concentration-dependent manner in PHE treated animals. Feeding with PHE attenuated high salt diet imposed derangement in serum lipid profile and antioxidant status in the organs of the experimental rats.

scholarly journals Effects of Sodium Glucose Cotransporter 2 Inhibitor on Renal Renin-Angiotensin-Aldsoterone System

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A439-A439
Author(s):  
Yoshiyu Takeda ◽  
Yoshimichi Takeda ◽  
Masashi Demura ◽  
Mitsuhiro Kometani ◽  
Shigehiro Karashima ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Rats ◽  
High Salt ◽  
Diabetic Patients ◽  
Mrna Levels ◽  
High Salt Diet ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Sodium Glucose Cotransporter ◽  
And Control

Abstract Objective: The renoprotective effect of sodium glucose cotransporter 2 inhibitor (SGL2i) has been reported in diabetic patients. Local renin-angiotensin-aldosterone system (RAAS) is activated in diabetes mellitus and hypertension. We examined the effects of SGL2i on the RAAS in the obese diabetic rats fed a high salt diet. Methods: Zucker-diabetic rats (ZDR) and control rats were fed a high or normal salt diet and were treated with canagliflozin for 8 weeks. Blood pressure (BP), blood glucose (BG), PRA, plasma aldosterone (PAC), urinary albumin excretion (UAE), urinary 8-hydroxy-2’-deoxyguanosine (8-OHdG), gene expression of angiotensinogen in the kidney were measured. Results: ZDR febd a high salt diet showed high BP, increased UAE and urinary 8-OHdG and elevated angiotensinogen mRNA levels. Treatment with canagliflozin significantly decreased BP, BG, UAE, urinary 8-OHdG and and renal angiotensinogen mRNA levels compared with control rats (p&lt0.05). Discussion and Conclusion: The closer mechanism of renoptotection of SGL2i in diabetes mellitus is unclear. We have reported that the repoprotective effects of type 2 angiotensin receptor antagonist or mineralocorticoid receptor blocker were partly due to the decreased RAAS in the kidney. Decreased renal RAAS by the treatment with canagliflozin may contribute to the renoprotection in DZR.

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