scholarly journals High glucocorticoids, in combination with high‐fat feeding, induces insulin resistance and hyperglycaemia: Mechanisms related to beta cell dysfunction?

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Jacqueline Leah Beaudry ◽  
Anna D'Souza ◽  
Michael Riddell
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
High Fat ◽  
Cell Dysfunction ◽  
Fat Feeding

scholarly journals Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

Diabetologia ◽  
2010 ◽  
Vol 53 (8) ◽  
pp. 1795-1806 ◽  
Author(s):  
J. A. Ehses ◽  
D. T. Meier ◽  
S. Wueest ◽  
J. Rytka ◽  
S. Boller ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
High Fat Diet ◽  
Beta Cell Dysfunction ◽  
Toll Like Receptor ◽  
High Fat ◽  
Cell Dysfunction ◽  
Toll Like Receptor 2 ◽  
Deficient Mice

Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results

2017 ◽  
Vol 68 (7) ◽  
pp. 1622-1627 ◽  
Author(s):  
Diana Simona Stefan ◽  
Andrada Mihai ◽  
Daiana Bajko ◽  
Daniela Lixandru ◽  
Laura Petcu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
Control Group ◽  
Cell Dysfunction ◽  
Randomized Controlled

Metabolic surgery is the most efficacious method for the treatment of morbid obesity and was recently included among the antidiabetes treatments recommended in obese type 2 diabetes (T2D) patients. The aim of this study was to compare in a randomized controlled trial the effect of sleeve gastrectomy (SG) to that of intensive lifestyle intervention plus pharmacologic treatment on some markers of insulin resistance and beta cell function as well as some appetite controlling hormones in a group of male obese T2D subjects. The study groups comprised 20 subjects for SG and 21 control subjects. Fasting blood glucose, insulin, proinsulin, adiponectin, leptin, ghrelin, HOMA-IR, HOMA-%B, proinsulin-to-insulin ratio and proinsulin-to-adiponectin ratio were evaluated at baseline and after one year follow-up. Overall, patients in the SG group lost 78.98% of excess weight loss (%EWL) in comparison with 9.45% in the control group. This was accompanied by a significant improvement of insulin resistance markers, including increase of adiponectin and decrease of HOMA-IR, while no changes were recorded in the control group. Weight loss was also associated with a significant improvement of proinsulin-to-insulin and proinsulin-to-adiponectin ratio, both surrogate markers of beta cell dysfunction. These also improved in the control group, but were only marginally significant. Our findings suggest that improved insulin resistance and decreased beta cell dysfunction after sleeve gastrectomy might explain diabetes remission associated with metabolic surgery.

scholarly journals Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1

2012 ◽  
Vol 36 (4) ◽  
pp. 275 ◽  
Author(s):  
Hannah Seok ◽  
Ji Young Lee ◽  
Eun Mi Park ◽  
Se Eun Park ◽  
Jae Hyuk Lee ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
High Fat ◽  
Cell Dysfunction ◽  
Balsamic Vinegar

scholarly journals Insulin resistance and beta-cell dysfunction in people with prediabetes according to criteria based on glycemia and glycosylated hemoglobin

2017 ◽  
Vol 64 (1) ◽  
pp. 117-122 ◽  
Author(s):  
Andrea Tura ◽  
Christian Göbl ◽  
Ermanno Moro ◽  
Giovanni Pacini
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
Glycosylated Hemoglobin ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction

scholarly journals Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yuying Wang ◽  
Heng Wan ◽  
Chi Chen ◽  
Yi Chen ◽  
Fangzhen Xia ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
Early Life ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Famine Exposure

scholarly journals A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes

Diabetes ◽  
2000 ◽  
Vol 49 (12) ◽  
pp. 2126-2134 ◽  
Author(s):  
F. Mauvais-Jarvis ◽  
A. Virkamaki ◽  
M. D. Michael ◽  
J. N. Winnay ◽  
A. Zisman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
Muscle Insulin Resistance ◽  
Cell Dysfunction

scholarly journals Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Haiyan Yang ◽  
Jie Lin ◽  
He Li ◽  
Zhangwei Liu ◽  
Xia Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
Polycystic Ovary ◽  
Serum Prolactin ◽  
Beta Cell Dysfunction ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Ovary Syndrome ◽  
Infertile Women ◽  
Cell Dysfunction

BackgroundOur study aimed to investigate if serum prolactin (PRL) levels associated with insulin resistance and beta-cell dysfunction in infertile patients with polycystic ovary syndrome (PCOS).MethodsThis was a retrospective cross-sectional study performed in the reproductive medicine center of the first affiliated hospital of Wenzhou Medical University. From January 2007 to August 2018, a total of 792 PCOS and 700 non-PCOS infertile women were included. All patients’ prolactin levels were in the normal range. PCOS was diagnosed according to the Rotterdam Criteria. Anthropometric parameters, blood pressure, serum prolactin levels, sex hormones, fasting lipids, fasting plasma glucose (FPG), fasting insulin (FINS) and hepatic biological parameters were measured in all subjects.ResultsSerum prolactin levels in PCOS women were significantly decreased compared with levels in non-PCOS women after adjusting for age and BMI (P < 0.05). Moreover, we found that prolactin levels were positively associated with high-density lipoprotein cholesterol (HDL-C) and negatively associated with age, BMI, waist circumference (WC), hip circumference (HC), luteinizing hormone/follicle stimulating hormone (LH/FSH), estradiol (E2), FINS, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β (HOMA-β), triglyceride (TG) and alanine aminotransferase (ALT) (P < 0.05). After adjusting for age and BMI, multiple linear regression analysis revealed that LH, LH/FSH, E2, FINS, HOMA-IR, and HOMA-β were negatively associated with serum PRL (P < 0.05).ConclusionsLow serum PRL levels within the normal range associates with a higher incidence of insulin resistance and beta-cell dysfunction in infertile women with PCOS.

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