scholarly journals Animal model for assessment pro‐inflammatory response of fat tissue and liver induced by prenatal stress and diet high in sugar and fat (840.14)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Lyudmyla Bezpalko ◽  
Oksana Zayachkivska ◽  
Elena Havryluk
Keyword(s):  
Animal Model ◽  
Inflammatory Response ◽  
Prenatal Stress ◽  
Fat Tissue

Evaluation of Inflammatory Response of EDTA, EDTA-T, and Citric Acid in Animal Model

2010 ◽  
Vol 36 (3) ◽  
pp. 515-519 ◽  
Author(s):  
Míriam F. Zaccaro Scelza ◽  
Viviane Santos da Silva Pierro ◽  
Mauricio Alves Chagas ◽  
Licinio Esmeraldo da Silva ◽  
Pantaleo Scelza
Keyword(s):  
Animal Model ◽  
Citric Acid ◽  
Inflammatory Response

scholarly journals Urokinase Attenuates Pulmonary Thromboembolism in an Animal Model by Inhibition of Inflammatory Response

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Ying Shi ◽  
Zhirong Zhang ◽  
Danli Cai ◽  
Jing Kuang ◽  
Shuifang Jin ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Animal Model ◽  
Inflammatory Response ◽  
Inflammatory Cell ◽  
Pulmonary Thromboembolism ◽  
Thrombus Formation ◽  
Inflammatory Cells ◽  
Hemodynamic Instability ◽  
Synergistic Action ◽  
Determining Factor

Inflammatory response is an important determining factor for the mortality of patients with pulmonary thromboembolism. Inflammatory mediators can promote thrombus formation and increase hemodynamic instability. Urokinase is a commonly used drug for the treatment of PTE. The effect of urokinase on inflammatory reaction in PTE is still unclear. Our study was aimed at evaluating the effects of the intervention of urokinase and urokinase combined with aspirin in PTE rats. Results revealed that a large amount of infiltrated inflammatory cells surrounding the bronchus, vessels, and pulmonary mesenchyme, and even pulmonary abscess were observed in the PTE rats. CX3CL1/CX3CR1 coexpression, CX3CL1/NF-κB coexpression, and TXA2 were significantly higher. After treatment with urokinase, pulmonary embolism was partially dissolved and inflammatory cell infiltration was significantly reduced. The expression of TNNI3, BNP, D2D, PASP, PADP, PAMP, and TXA2, as well as CX3CL1/CX3CR1 coexpression and CX3CL1/NF-κB coexpression were significantly lowered. Aspirin showed no synergistic action. Therefore, these findings suggested the occurrence of inflammation during the process of PTE in rats. Urokinase treatment reduced the inflammatory response.

scholarly journals A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nalú Navarro-Alvarez ◽  
Beatriz M. M. Gonçalves ◽  
Alec R. Andrews ◽  
David H. Sachs ◽  
Christene A. Huang
Keyword(s):  
Animal Model ◽  
Inflammatory Response ◽  
Skin Disease ◽  
Pain Medication ◽  
Abnormal Behavior ◽  
Large Animal Model ◽  
Large Animal ◽  
Late Time ◽  
Inflammatory Skin Disease ◽  
Inflammatory Skin

Similarities between porcine and human skin make the pig an ideal model for preclinical studies of cutaneous inflammation and wound healing. Complete Freund’s adjuvant (CFA) has been used to induce inflammation and to study inflammatory pain in several animal models. Here, we evaluated the inflammation caused by CFA injected in different layers of skin and subcutaneous (SC) tissue in a large-animal model. The degree of inflammation was evaluated at early and late time points by visual inspection and histopathologic analysis. In addition, the side effects of CFA injections were evaluated based on clinical findings, behavioral changes, physiologic state, and (histo)pathologic lesions. Pigs were injected with CFA at the back of the neck’s skin at different depths. All animals showed histologic signs of inflammation at the injection site. Animals injected SC did not show any signs of pain or distress (loss of appetite, abnormal behavior) and did not require pain medication. Inflammation was followed by measuring the area of induration beneath the skin. Animals injected into the dermis and/or epidermis demonstrated a severe inflammatory response on the skin surface with massive swelling, redness within 12hrs of CFA injection, and severe skin necrosis within a week, preventing accurate induration measurements. In contrast to animals injected SC, animals receiving intradermal and/or intraepidermal injection of CFA showed signs of distress requiring pain medication. Conclusion. SC injection of CFA in swine induces an inflammatory response that can be measured accurately by induration without causing unnecessary discomfort, providing a useful preclinical large-animal model of inflammatory skin disease.

scholarly journals Abstract 1940: Prenatal stress increases malignancy of neuroblastoma tumors in TH-MYCN animal model

2017 ◽  
Author(s):  
Sung Hyeok Hong ◽  
Larissa Wietlisbach ◽  
Susana Galli ◽  
Akanksha Mahajan ◽  
Shiya Zhu ◽  
...  
Keyword(s):  
Animal Model ◽  
Prenatal Stress
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