Diverse Classes of Bitter Phytochemicals Modulate Carbohydrate Metabolism and Immune Responses through Gastrointestinal Bitter Taste Receptors

The FASEB Journal ◽

10.1096/fasebj.29.1_supplement.405.5 ◽

2015 ◽

Vol 29 (S1) ◽

Author(s):

Kimberly Palatini ◽

Mickey Wilson ◽

Jessica Alley ◽

Debora Esposito ◽

Slavko Komarnytsky

Keyword(s):

Immune Responses ◽

Carbohydrate Metabolism ◽

Bitter Taste ◽

Taste Receptors ◽

Bitter Taste Receptors

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Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity

Journal of Clinical Investigation ◽

10.1172/jci144828 ◽

2021 ◽

Author(s):

Kathrin I. Liszt ◽

Qiaoling Wang ◽

Mona Farhadipour ◽

Anneleen Segers ◽

Theo Thijs ◽

...

Keyword(s):

Immune Responses ◽

Bitter Taste ◽

Innate Immune ◽

Taste Receptors ◽

Innate Immune Responses ◽

Bitter Taste Receptors ◽

Metabolic Regulators

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Faculty Opinions recommendation of Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12832960.14116059 ◽

2011 ◽

Author(s):

Sue Kinnamon

Keyword(s):

Large Intestine ◽

Bitter Taste ◽

Taste Receptors ◽

Bitter Taste Receptors

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Faculty Opinions recommendation of Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.6185956.6457058 ◽

2010 ◽

Author(s):

Philip Murphy ◽

Erich Schneider

Keyword(s):

Smooth Muscle ◽

Calcium Signaling ◽

Airway Smooth Muscle ◽

Bitter Taste ◽

Taste Receptors ◽

Bitter Taste Receptors

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Faculty Opinions recommendation of Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.6185956.6262064 ◽

2010 ◽

Author(s):

Domenico Spina ◽

Abigail Morris

Keyword(s):

Smooth Muscle ◽

Calcium Signaling ◽

Airway Smooth Muscle ◽

Bitter Taste ◽

Taste Receptors ◽

Bitter Taste Receptors

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Faculty Opinions recommendation of Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.6185956.10729055 ◽

2011 ◽

Author(s):

Bruce Levy ◽

Jennifer Colby

Keyword(s):

Smooth Muscle ◽

Calcium Signaling ◽

Airway Smooth Muscle ◽

Bitter Taste ◽

Taste Receptors ◽

Bitter Taste Receptors

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Faculty Opinions recommendation of Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.8213956.14116055 ◽

2011 ◽

Author(s):

Thomas Finger

Keyword(s):

Gastric Emptying ◽

Food Intake ◽

Bitter Taste ◽

Taste Receptors ◽

Bitter Taste Receptors

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M1659 Agonists of Bitter Taste Receptors Activate the Gut-Brain Axis and Influence Food Intake and Gastrointestinal Function in Mice

Gastroenterology ◽

10.1016/s0016-5085(08)61829-6 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-392

Author(s):

Shuzhen Hao ◽

Elvis G. Espero ◽

Michelle Dulake ◽

Catia Sternini ◽

Linda Rinaman ◽

...

Keyword(s):

Food Intake ◽

Bitter Taste ◽

Gastrointestinal Function ◽

Taste Receptors ◽

Bitter Taste Receptors

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Bitter Taste Receptors (TAS2RS) Regulate Gastric Accommodation Following Liquid Meal Administration in Guinea Pigs

Gastroenterology ◽

10.1016/s0016-5085(17)33186-4 ◽

2017 ◽

Vol 152 (5) ◽

pp. S934

Author(s):

Yumi Harada ◽

Junichi Koseki ◽

Hitomi Sekine ◽

Naoki Fujitsuka ◽

Tomohisa Hattori ◽

...

Keyword(s):

Guinea Pigs ◽

Bitter Taste ◽

Taste Receptors ◽

Gastric Accommodation ◽

Liquid Meal ◽

Bitter Taste Receptors

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TAS2R bitter taste receptors regulate thyroid function

The FASEB Journal ◽

10.1096/fj.14-262246 ◽

2014 ◽

Vol 29 (1) ◽

pp. 164-172 ◽

Author(s):

Adam A. Clark ◽

Cedrick D. Dotson ◽

Amanda E. T. Elson ◽

Anja Voigt ◽

Ulrich Boehm ◽

...

Keyword(s):

Thyroid Function ◽

Bitter Taste ◽

Taste Receptors ◽

Bitter Taste Receptors

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Trp-Trp acts as a multi-functional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46

Bioscience Biotechnology and Biochemistry ◽

10.1093/bbb/zbab061 ◽

2021 ◽

Author(s):

Ichie Ojiro ◽

Hiromi Nishio ◽

Toyomi Yamazaki-Ito ◽

Shogo Nakano ◽

Sohei Ito ◽

...

Keyword(s):

Functional Food ◽

Functional Foods ◽

Bitter Taste ◽

Functional Characteristic ◽

Taste Receptors ◽

Food Ingredients ◽

Masking Agents ◽

Bitter Taste Receptors ◽

Bitterness Masking

Abstract Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multi-functional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.

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