scholarly journals miRNA‐29b Directly Downregulates K + Channel Expression and Function in IPAH‐PASMC

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Ramon Ayon ◽  
Nicole Pohl ◽  
Aya Yamamura ◽  
Hisao Yamamura ◽  
Ayako Makino ◽  
...  
Keyword(s):  
K Channel ◽  
Channel Expression ◽  
And Function

scholarly journals Reduced Na + and higher K + channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice

Open Biology ◽  
2012 ◽  
Vol 2 (6) ◽  
pp. 120072 ◽  
Author(s):  
Claire A. Martin ◽  
Urszula Siedlecka ◽  
Kristin Kemmerich ◽  
Jason Lawrence ◽  
James Cartledge ◽  
...  
Keyword(s):  
Voltage Dependence ◽  
Outward Current ◽  
K Channel ◽  
Transient Outward Current ◽  
Wild Type ◽  
Channel Expression ◽  
Mrna And Protein Expression ◽  
The Right ◽  
And Function ◽  
Electrophysiological Mechanism

Brugada syndrome (BrS) is associated with ventricular tachycardia originating particularly in the right ventricle (RV). We explore electrophysiological features predisposing to such arrhythmic tendency and their possible RV localization in a heterozygotic Scn5a+/− murine model. Na v 1.5 mRNA and protein expression were lower in Scn5a+/− than wild-type (WT), with a further reduction in the RV compared with the left ventricle (LV). RVs showed higher expression levels of K v 4.2, K v 4.3 and KChIP2 in both Scn5a+/− and WT. Action potential upstroke velocity and maximum Na + current ( I Na ) density were correspondingly decreased in Scn5a+/− , with a further reduction in the RV. The voltage dependence of inactivation was shifted to more negative values in Scn5a+/−. These findings are predictive of a localized depolarization abnormality leading to slowed conduction. Persistent Na + current ( I pNa ) density was decreased in a similar pattern to I Na . RV transient outward current ( I to ) density was greater than LV in both WT and Scn5a+/− , and had larger time constants of inactivation. These findings were also consistent with the observation that AP durations were smallest in the RV of Scn5a+/− , fulfilling predictions of an increased heterogeneity of repolarization as an additional possible electrophysiological mechanism for arrhythmogenesis in BrS.

scholarly journals KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145259 ◽  
Author(s):  
Greer K. Arthur ◽  
S. Mark Duffy ◽  
Katy M. Roach ◽  
Rob A. Hirst ◽  
Aarti Shikotra ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Bronchial Epithelial Cells ◽  
K Channel ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial ◽  
Channel Expression ◽  
And Function

scholarly journals E Right ventricular origin of arrhythmias inScn5a+/− mice is due to reduced Na+ and higher K+ channel expression and function

Heart ◽  
2012 ◽  
Vol 98 (Suppl 1) ◽  
pp. A2.2-A3
Author(s):  
C A Martin ◽  
U Siedlecka ◽  
K Kemmerich ◽  
J Lawrence ◽  
J Cartledge ◽  
...  
Keyword(s):  
Right Ventricular ◽  
K Channel ◽  
Channel Expression ◽  
And Function

scholarly journals Developmental Regulation of Small-Conductance Ca2+-Activated K+ Channel Expression and Function in Rat Purkinje Neurons

2002 ◽  
Vol 22 (11) ◽  
pp. 4456-4467 ◽  
Author(s):  
Lorenzo A. Cingolani ◽  
Marco Gymnopoulos ◽  
Anna Boccaccio ◽  
Martin Stocker ◽  
Paola Pedarzani
Keyword(s):  
Developmental Regulation ◽  
Purkinje Neurons ◽  
K Channel ◽  
Channel Expression ◽  
And Function ◽  
Small Conductance
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