FAK association with multiple signal proteins mediates pressure‐induced colon cancer cell adhesion via a Src‐dependent PI3K/Akt pathway

2007 ◽  
Vol 21 (8) ◽  
pp. 1730-1741 ◽  
Author(s):  
Vijayalakshmi Thamilselvan ◽  
David H. Craig ◽  
Marc D. Basson
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Akt Pathway ◽  
Multiple Signal ◽  
Cancer Cell Adhesion

scholarly journals CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells

2021 ◽  
Author(s):  
Mattias Lepsenyi ◽  
Nader Algethami ◽  
Amr A. Al-Haidari ◽  
Anwar Algaber ◽  
Ingvar Syk ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Colon Cancer Cells ◽  
Cancer Cell Adhesion ◽  
And Migration ◽  
Cxcr2 Antagonist

AbstractPeritoneal metastasis is an insidious aspect of colorectal cancer. The aim of the present study was to define mechanisms regulating colon cancer cell adhesion and spread to peritoneal wounds after abdominal surgery. Mice was laparotomized and injected intraperitoneally with CT-26 colon carcinoma cells and metastatic noduli in the peritoneal cavity was quantified after treatment with a CXCR2 antagonist or integrin-αV-antibody. CT-26 cells expressed cell surface chemokine receptors CXCR2, CXCR3, CXCR4 and CXCR5. Stimulation with the CXCR2 ligand, CXCL2, dose-dependently increased proliferation and migration of CT-26 cells in vitro. The CXCR2 antagonist, SB225002, dose-dependently decreased CXCL2-induced proliferation and migration of colon cancer cells in vitro. Intraperitoneal administration of CT-26 colon cancer cells resulted in wide-spread growth of metastatic nodules at the peritoneal surface of laparotomized animals. Laparotomy increased gene expression of CXCL2 at the incisional line. Pretreatment with CXCR2 antagonist reduced metastatic nodules by 70%. Moreover, stimulation with CXCL2 increased CT-26 cell adhesion to extracellular matrix (ECM) proteins in a CXCR2-dependent manner. CT-26 cells expressed the αV, β1 and β3 integrin subunits and immunoneutralization of αV abolished CXCL2-triggered adhesion of CT-26 to vitronectin, fibronectin and fibrinogen. Finally, inhibition of the αV integrin significantly attenuated the number of carcinomatosis nodules by 69% in laparotomized mice. These results were validated by use of the human colon cancer cell line HT-29 in vitro. Our data show that colon cancer cell adhesion and growth on peritoneal wound sites is mediated by a CXCL2-CXCR2 signaling axis and αV integrin-dependent adhesion to ECM proteins.

Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin

2005 ◽  
Vol 96 (2) ◽  
pp. 93-99 ◽  
Author(s):  
Kentaro Yazawa ◽  
Nelson H. Tsuno ◽  
Joji Kitayama ◽  
Kazushige Kawai ◽  
Yurai Okaji ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Selective Inhibition ◽  
Colon Cancer Cell ◽  
Cyclooxygenase 2 ◽  
Cancer Cell Adhesion ◽  
Beta1 Integrin

Pressure activates colon cancer cell adhesion by inside-out FAK, src and cytoskeletal signaling

2003 ◽  
Vol 124 (4) ◽  
pp. A604
Author(s):  
Vijayalakshmi Thamilselvan ◽  
Richard J. Gilbert ◽  
Marc D. Basson
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Adhesion ◽  
Inside Out

Abstract 2365: A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

2018 ◽  
Author(s):  
Kelley E. McQueeney ◽  
Joseph M. Salamoun ◽  
Jennifer Ahn ◽  
Paula Pekic ◽  
Isabella K. Blanco ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Chemical Genetics ◽  
Colon Cancer Cell ◽  
Cancer Cell Adhesion

Effects of increased ambient pressure on colon cancer cell adhesion

2000 ◽  
Vol 78 (1) ◽  
pp. 47-61 ◽  
Author(s):  
Marc D. Basson ◽  
Cheng Fang Yu ◽  
Oliver Herden-Kirchoff ◽  
Marc Ellermeier ◽  
Matthew A. Sanders ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Ambient Pressure ◽  
Colon Cancer Cell ◽  
Cancer Cell Adhesion

scholarly journals A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

2018 ◽  
Vol 32 (10) ◽  
pp. 5661-5673 ◽  
Author(s):  
Kelley E. McQueeney ◽  
Joseph M. Salamoun ◽  
Jennifer G. Ahn ◽  
Paula Pekic ◽  
Isabella K. Blanco ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Chemical Genetics ◽  
Colon Cancer Cell ◽  
Cancer Cell Adhesion

Regulatory effect of interleukin-4 on the function of colon cancer cell adhesion

1998 ◽  
Vol 114 ◽  
pp. A651
Author(s):  
M Naganuma ◽  
T Kanai ◽  
M Watanabe ◽  
A Nakazawa ◽  
T Yajima ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Interleukin 4 ◽  
Regulatory Effect ◽  
Cancer Cell Adhesion

Divalent cations modulate human colon cancer cell adhesion

2003 ◽  
Vol 110 (1) ◽  
pp. 255-265 ◽  
Author(s):  
Vijayalakshmi Thamilselvan ◽  
Marina Fomby ◽  
Mary Walsh ◽  
Marc D Basson
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Divalent Cations ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Cancer Cell Adhesion
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