EFFECTS OF VASODILATOR DRUGS AND OTHER PROCEDURES ON DIGITAL CUTANEOUS BLOOD FLOW, CARDIAC OUTPUT, BLOOD PRESSURE, PULSE RATE, BODY TEMPERATURE, AND METABOLIC RATE

1949 ◽  
Vol 218 (6) ◽  
pp. 669-682 ◽  
Author(s):  
Orville Horwitz ◽  
Hugh Montgomery ◽  
Edwin Downs Longaker ◽  
Ann Saÿen
1963 ◽  
Vol 204 (2) ◽  
pp. 301-303 ◽  
Author(s):  
L. Takács ◽  
V. Vajda

The effects of intraperitoneal and intravenous administration of serotonin on cardiac output, blood pressure, and organ distribution of blood flow (Rb86) were studied in the rat. Fifteen to thirty minutes after intraperitoneal injection (10 mg/kg) cardiac output was unchanged, while blood pressure was significantly reduced. Increase in blood flow was noted in the myocardium, pulmonary parenchyma and "carcass" (skeletal muscle, bone, CNS), with decrease in the kidney and the skin. Splanchnic blood flow was unchanged. Conversely, intravenous infusion of serotonin produced an increase of cardiac output, blood pressure, and cutaneous blood flow.


2015 ◽  
Vol 30 (12) ◽  
pp. 2075-2079 ◽  
Author(s):  
Philip Andreas Schytz ◽  
Maria Lerche Mace ◽  
Anne Merete Boas Soja ◽  
Brian Nilsson ◽  
Nikolaos Karamperis ◽  
...  

1984 ◽  
Vol 246 (3) ◽  
pp. R321-R324 ◽  
Author(s):  
L. A. Stephenson ◽  
C. B. Wenger ◽  
B. H. O'Donovan ◽  
E. R. Nadel

To characterize the changes in the control of the heat loss responses associated with the circadian variation in body temperature, we studied five men during 20 min of exercise in 25 degrees C on 6 separate days. Experiments were conducted at six times, equally spaced over the 24-h day. Esophageal temperature (Tes) and chest sweat rate (msw) were measured continuously, and forearm blood flow (FBF) was measured one to two times per minute. The thresholds for sweating and forearm vasodilation were significantly higher at 1600 and 2000 than at 2400 and 0400, averaging 0.57 and 0.65 degrees C higher, respectively, at 1600 than at 0400. Resting Tes and the Tes thresholds for cutaneous vasodilation and sweating during exercise all showed a similar circadian rhythm. The level at which core temperature is regulated therefore varies over the 24-h day with the zenith occurring around 1600 and the nadir at 0400. However, whereas the slope of the msw-to-Tes relation did not change over the 24-h day, the slope of the FBF-to-Tes relation tended to increase between 0400 and 2400, implying that the circadian rhythm may be more complex than just a shift in the central reference temperature.


1983 ◽  
Vol 17 (4) ◽  
pp. 321-323 ◽  
Author(s):  
H. Minasian ◽  
D. Minassian

To determine the relationship between mammary and cutaneous blood flow (BF) the regional distribution of 86RbCl was used to estimate the fractional distribution of the cardiac output to these tissues in virgin, multiparous, pregnant and lactating mice. The results indicate a positive linear correlation between the values obtained for the skin and that obtained for its underlying mammary tissue. This finding may have a practical application, since the skin is more readily accessible for BF measurements than the mammary tissue that it covers.


2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Koichi Shimo ◽  
Ko Takakura ◽  
Kenji Shigemi

The aim of this study is to investigate how elevation of body temperature changes organs blood flow during sevoflurane anesthesia. We conducted in vivo research on 14 male Wistar rats to monitor pulse rate and arterial blood pressure and measure hepatic, small intestinal, renal, and descending aortic blood flow using a laser Doppler blood flowmeter. We assessed the changes in organ blood flow, pulse rate, and arterial blood pressure during elevation of the rats’ body temperatures up to 41.5°C under anesthesia with 2.0% or 3.0% sevoflurane. We concluded that elevation of body temperature up to 39.5°C does not change hepatic, small intestinal, and renal blood flow during 2.0 and 3.0% sevoflurane anesthesia.


1999 ◽  
Vol 86 (3) ◽  
pp. 799-805 ◽  
Author(s):  
Ricardo G. Fritzsche ◽  
Thomas W. Switzer ◽  
Bradley J. Hodgkinson ◽  
Edward F. Coyle

This study determined whether the decline in stroke volume (SV) during prolonged exercise is related to an increase in heart rate (HR) and/or an increase in cutaneous blood flow (CBF). Seven active men cycled for 60 min at ∼57% peak O2 uptake in a neutral environment (i.e., 27°C, <40% relative humidity). They received a placebo control (CON) or a small oral dose (i.e., ∼7 mg) of the β1-adrenoceptor blocker atenolol (BB) at the onset of exercise. At 15 min, HR and SV were similar during CON and BB. From 15 to 55 min during CON, a 13% decline in SV was associated with an 11% increase in HR and not with an increase in CBF. CBF increased mainly from 5 to 15 min and remained stable from 20 to 60 min of exercise in both treatments. However, from 15 to 55 min during BB, when the increase in HR was prevented by atenolol, the decline in SV was also prevented, despite a normal CBF response (i.e., similar to CON). Cardiac output was similar in both treatments and stable throughout the exercise bouts. We conclude that during prolonged exercise in a neutral environment the decline in SV is related to the increase in HR and is not affected by CBF.


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