Acute Lung Injury: What Have We Learned from Animal Models?

1993 ◽  
Vol 306 (2) ◽  
pp. 111-116 ◽  
Author(s):  
A.C.J. Windsor ◽  
P.G. Mullen ◽  
A.A. Fowler
Keyword(s):  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury

scholarly journals Induction of type-IIA secretory phospholipase A2 in animal models of acute lung injury

2003 ◽  
Vol 21 (6) ◽  
pp. 1040-1045 ◽  
Author(s):  
H.L. Attalah ◽  
Y. Wu ◽  
M. Alaoui-El-Azher ◽  
F. Thouron ◽  
K. Koumanov ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase

scholarly journals Animal models of acute lung injury

2008 ◽  
Vol 295 (3) ◽  
pp. L379-L399 ◽  
Author(s):  
Gustavo Matute-Bello ◽  
Charles W. Frevert ◽  
Thomas R. Martin
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Animal Studies ◽  
Ischemia Reperfusion ◽  
Alveolar Epithelium ◽  
Acid Aspiration ◽  
Advantages And Disadvantages ◽  
Clinical Risks

Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline membrane formation, and microvascular thrombi. Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury. Most are based on reproducing in animals known risk factors for ARDS, such as sepsis, lipid embolism secondary to bone fracture, acid aspiration, ischemia-reperfusion of pulmonary or distal vascular beds, and other clinical risks. However, none of these models fully reproduces the features of human lung injury. The goal of this review is to summarize the strengths and weaknesses of existing models of lung injury. We review the specific features of human ARDS that should be modeled in experimental lung injury and then discuss specific characteristics of animal species that may affect the pulmonary host response to noxious stimuli. We emphasize those models of lung injury that are based on reproducing risk factors for human ARDS in animals and discuss the advantages and disadvantages of each model and the extent to which each model reproduces human ARDS. The present review will help guide investigators in the design and interpretation of animal studies of acute lung injury.

A comparison among animal models of acute lung injury

1998 ◽  
Vol 26 (5) ◽  
pp. 912-916 ◽  
Author(s):  
Cynthia Rosenthal ◽  
Catherine Caronia ◽  
Carolyn Quinn ◽  
Nitza Lugo ◽  
Mayer Sagy
Keyword(s):  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury

Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ryan McGinn ◽  
Dean A. Fergusson ◽  
Duncan J. Stewart ◽  
Arnold S. Kristof ◽  
Carly C. Barron ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Small Animal ◽  
Small Animal Models

scholarly journals Overview of the Pathology of Three Widely Used Animal Models of Acute Lung Injury

2008 ◽  
Vol 40 (4) ◽  
pp. 305-316 ◽  
Author(s):  
H.M. Wang ◽  
M. Bodenstein ◽  
K. Markstaller
Keyword(s):  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury

Delivery of the high-mobility group box 1 box A peptide using heparin in the acute lung injury animal models

2016 ◽  
Vol 234 ◽  
pp. 33-40 ◽  
Author(s):  
Ji Hyun Song ◽  
Ji Yeon Kim ◽  
Chunxian Piao ◽  
Seonyeong Lee ◽  
Bora Kim ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147170 ◽  
Author(s):  
Lauralyn A. McIntyre ◽  
David Moher ◽  
Dean A. Fergusson ◽  
Katrina J. Sullivan ◽  
Shirley H. J. Mei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Cell Therapy ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Preclinical Animal Models

Animal models of transfusion-related acute lung injury

2006 ◽  
Vol 34 (Suppl) ◽  
pp. S132-S136 ◽  
Author(s):  
Mark R. Looney ◽  
Michael A. Matthay
Keyword(s):  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury
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