scholarly journals Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147170 ◽  
Author(s):  
Lauralyn A. McIntyre ◽  
David Moher ◽  
Dean A. Fergusson ◽  
Katrina J. Sullivan ◽  
Shirley H. J. Mei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Cell Therapy ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Preclinical Animal Models

Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury

2019 ◽  
Vol 199 (10) ◽  
pp. 1214-1224 ◽  
Author(s):  
Diana Islam ◽  
Yongbo Huang ◽  
Vito Fanelli ◽  
Luisa Delsedime ◽  
Sulong Wu ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Cell Therapy ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell

Mesenchymal stromal cell injection protects against oxidative stress in Escherichia coli–induced acute lung injury in mice

Cytotherapy ◽  
2014 ◽  
Vol 16 (6) ◽  
pp. 764-775 ◽  
Author(s):  
Sally M. Shalaby ◽  
Amal S. El-Shal ◽  
Somia H. Abd-Allah ◽  
Assmaa O. Selim ◽  
Sally A. Selim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Escherichia Coli ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Cell Injection

Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis

2016 ◽  
Vol 3 (1) ◽  
pp. e45-e52 ◽  
Author(s):  
Shahrukh Hashmi ◽  
Mohammad Ahmed ◽  
M Hassan Murad ◽  
Mark R Litzow ◽  
Roberta H Adams ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cell Therapy ◽  
Graft Versus Host Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Meta Analysis ◽  
Host Disease ◽  
Graft Versus Host ◽  
Steroid Refractory ◽  
Acute Graft

scholarly journals Effects of mesenchymal stromal cell-conditioned media on measures of lung structure and function: a systematic review and meta-analysis of preclinical studies

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Alvaro Moreira ◽  
Rija Naqvi ◽  
Kristen Hall ◽  
Chimobi Emukah ◽  
John Martinez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Lung Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Lung ◽  
Meta Analysis ◽  
Structure And Function ◽  
Lung Structure ◽  
And Function

Abstract Background Lung disease is a leading cause of morbidity and mortality. A breach in the lung alveolar-epithelial barrier and impairment in lung function are hallmarks of acute and chronic pulmonary illness. This review is part two of our previous work. In part 1, we demonstrated that CdM is as effective as MSCs in modulating inflammation. Herein, we investigated the effects of mesenchymal stromal cell (MSC)-conditioned media (CdM) on (i) lung architecture/function in animal models mimicking human lung disease, and (ii) performed a head-to-head comparison of CdM to MSCs. Methods Adhering to the animal Systematic Review Centre for Laboratory animal Experimentation protocol, we conducted a search of English articles in five medical databases. Two independent investigators collected information regarding lung: alveolarization, vasculogenesis, permeability, histologic injury, compliance, and measures of right ventricular hypertrophy and right pulmonary pressure. Meta-analysis was performed to generate random effect size using standardized mean difference with 95% confidence interval. Results A total of 29 studies met inclusion. Lung diseases included bronchopulmonary dysplasia, asthma, pulmonary hypertension, acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis. CdM improved all measures of lung structure and function. Moreover, no statistical difference was observed in any of the lung measures between MSCs and CdM. Conclusions In this meta-analysis of animal models recapitulating human lung disease, CdM improved lung structure and function and had an effect size comparable to MSCs.

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