Multiple Smooth Muscle Tumors Arising in Deep Soft Tissue of Lower Limbs With Uterine Leiomyomas

1998 ◽  
Vol 22 (7) ◽  
pp. 897-901 ◽  
Author(s):  
Keisuke Horiuchi ◽  
Hiroo Yabe ◽  
Makio Mukai ◽  
Hideo Morioka ◽  
Yasuhiro Udagawa ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Soft Tissue ◽  
Uterine Leiomyomas ◽  
Lower Limbs ◽  
Deep Soft Tissue ◽  
Smooth Muscle Tumors

scholarly journals Benign Smooth Muscle Tumors (Leiomyomas) of Deep Somatic Soft Tissue

Sarcoma ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Aoife J. McCarthy ◽  
Runjan Chetty
Keyword(s):  
Smooth Muscle ◽  
Soft Tissue ◽  
Mitotic Activity ◽  
Smooth Muscle Tumor ◽  
Deep Soft Tissue ◽  
Spindle Cells ◽  
Histological Criteria ◽  
Smooth Muscle Tumors ◽  
Atypical Cells

Leiomyomas of deep soft tissue are extremely rare and should only be diagnosed following adherence to stringent histological criteria, namely, the absence of nuclear atypia and of coagulative tumor necrosis. Whether extremely low counts of, or even any, mitotic activity are acceptable when making a diagnosis of leiomyoma in deep soft tissue sites is controversial. The morphology and immunophenotype of smooth muscle tumors in deep soft tissue are similar to their counterparts irrespective of topography. It is interesting to note that leiomyomas of deep soft tissue (extremity and retroperitoneum) are often hyalinized/sclerosed and calcified. However, the prediction of their behavior and correct codification is dependent on thorough, meticulous search for mitoses and necrosis. Leiomyomas of deep soft tissue in the extremity should be devoid of mitoses and “significant” cytological atypia. An occasional larger, slightly pleomorphic cell in the midst of bland spindle cells, can be regarded as insignificant atypia. If any mitotic activity and several atypical cells are encountered in smooth muscle tumors of deep soft tissue of the extremity, it would be prudent to invoke the appellation of smooth muscle tumor of uncertain malignant potential and advocate wide local excision and follow-up.

Malignant smooth muscle tumors presenting as mediastinal soft tissue masses. A clinicopathologic study of 10 cases

Cancer ◽  
1994 ◽  
Vol 74 (8) ◽  
pp. 2251-2260 ◽  
Author(s):  
Cesar A. Moran ◽  
Michael N. Koss ◽  
Saul Suster ◽  
Giorgio Perino ◽  
Mamoru Kaneko
Keyword(s):  
Smooth Muscle ◽  
Soft Tissue ◽  
Clinicopathologic Study ◽  
Smooth Muscle Tumors ◽  
Soft Tissue Masses

The Use of Smoothelin and Other Antibodies in the Diagnosis of Uterine and Soft Tissue Smooth Muscle Tumors

2019 ◽  
Vol 27 (5) ◽  
pp. 386-391
Author(s):  
Kim Greg Mayhall ◽  
Estelle Oertling ◽  
Eleanor Lewin ◽  
John Schmieg ◽  
Helena LeBeau ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Soft Tissue ◽  
Smooth Muscle Tumors

Canine smooth muscle tumors: A clinicopathological study

2021 ◽  
pp. 030098582110668
Author(s):  
Giancarlo Avallone ◽  
Valeria Pellegrino ◽  
Luisa Vera Muscatello ◽  
Paola Roccabianca ◽  
Gastone Castellani ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Soft Tissue ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Mitotic Count ◽  
Labeling Index ◽  
Ki67 Labeling Index ◽  
Smooth Muscle Tumors ◽  
Criteria Of Malignancy ◽  
Female Genital

Canine smooth muscle tumors (SMTs) commonly develop in the alimentary and female genital tracts and less frequently in soft tissue. The definition of histological criteria of malignancy is less detailed for SMTs in dogs than in humans. This study evaluated the clinicopathologic features of canine SMTs and compared the veterinary and human medical criteria of malignancy. A total of 105 canine SMTs were evaluated histologically and classified according to both veterinary and human criteria. The Ki67 labeling index was assessed in all SMTs. Estrogen receptor (ER) and progesterone receptor (PR) expression was evaluated for soft tissue SMTs. Follow-up data were available in 25 cases. SMTs were diagnosed in the female genital tract (42%), alimentary tract (22%), and soft tissue (20%). Soft tissue SMTs frequently arose in the perigenital area, pelvic cavity, and retroperitoneum. A subset of soft tissue SMTs expressed ER and/or PR, resembling the gynecologic type of soft tissue SMT in humans. SMTs were less frequently malignant when assessed with human criteria than with veterinary criteria, better reflecting their benign behavior, especially in the genital tract where human criteria tolerate a higher mitotic count for leiomyoma. Decreased differentiation was correlated with increased proliferation, necrosis, and reduced desmin expression. Mitotic count, Ki67 labeling index, and necrosis were correlated with metastases and tumor-related death. Further prognostic studies are warranted to confirm the better performance of the human criteria when assessing SMT malignancy, especially genital cases, to confirm their usefulness in ER/PR-expressing soft tissue SMTs, and to better define the most useful prognostic parameters for canine SMTs.

scholarly journals CDK-inhibitors-associated kinase activity: A possible determinant of malignant potential in smooth muscle tumors of the external soft tissue

2001 ◽  
Vol 94 (3) ◽  
pp. 353-362 ◽  
Author(s):  
Yoh Dobashi ◽  
Takashi Noguchi ◽  
Shuji Nasuno ◽  
Kazuhiro Katayama ◽  
Toru Kameya
Keyword(s):  
Smooth Muscle ◽  
Soft Tissue ◽  
Kinase Activity ◽  
Malignant Potential ◽  
Cdk Inhibitors ◽  
Smooth Muscle Tumors

scholarly journals Involvement of Cyclins in Cell Proliferation and Their Clinical Implications in Soft Tissue Smooth Muscle Tumors

2000 ◽  
Vol 156 (6) ◽  
pp. 2135-2147 ◽  
Author(s):  
Takashi Noguchi ◽  
Yoh Dobashi ◽  
Hiroaki Minehara ◽  
Moritoshi Itoman ◽  
Toru Kameya
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Soft Tissue ◽  
Clinical Implications ◽  
Smooth Muscle Tumors

scholarly journals Case for diagnosis

2012 ◽  
Vol 87 (2) ◽  
pp. 322-323 ◽  
Author(s):  
Ludmilla Queirós Miranda ◽  
Fernanda Valente da Silva Rehfeldt ◽  
Roberto Souto da Silva ◽  
João Carlos Macedo Fonseca ◽  
Maria de Fátima Guimarães Scotelaro Alves
Keyword(s):  
Smooth Muscle ◽  
Lower Limbs ◽  
Left Hand ◽  
Unusual Location ◽  
Vascular Leiomyoma ◽  
Smooth Muscle Tumors

Vascular leiomyoma are uncommon benign smooth muscle tumors which generally present as a single painful nodule in the lower limbs. We report a case of vascular leiomyoma on the second finger of the left hand, an unusual location for this tumor.

scholarly journals Leiomyoma of the Vulva: A Diagnostic Challenge Case Report

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Saad Kurdi ◽  
Abdullah S. Arafat ◽  
Maysan Almegbel ◽  
Mayson Aladham
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Spinal Anaesthesia ◽  
Final Diagnosis ◽  
Uterine Leiomyomas ◽  
Age Group ◽  
Diagnostic Challenge ◽  
Smooth Muscle Tumors ◽  
History Of

Uterine leiomyomas are common and can affect up to 30% of women older than 35 years. Despite this, leiomyomas of the vulva are rare, masquerading, and usually misdiagnosed as Bartholin cyst preoperatively. These smooth muscle tumors are typically painless, solitary, and well circumscribed and can affect female of any age group. We present a case of a 46-year-old female that presented to the clinic with 2-year history of right labial mass and was diagnosed as Bartholin cyst initially. The patient underwent elective excision under spinal anaesthesia and the mass was removed. The final diagnosis after microscopy result showed benign vulvar leiomyoma.

Sign in / Sign up

Export Citation Format

Share Document