Tone Abnormalities Are Associated with Maternal Cigarette Smoking During Pregnancy in In Utero Cocaine-Exposed Infants

2001 ◽  
Vol 13 (3) ◽  
pp. 143-144
Author(s):  
Wendy M. Kahler
2012 ◽  
Vol 24 (4) ◽  
pp. 1377-1390 ◽  
Author(s):  
Valerie S. Knopik ◽  
Matthew A. Maccani ◽  
Sarah Francazio ◽  
John E. McGeary

AbstractThe period of in utero development is one of the most critical windows during which adverse intrauterine conditions and exposures can influence the growth and development of the fetus as well as the child's future postnatal health and behavior. Maternal cigarette smoking during pregnancy remains a relatively common but nonetheless hazardous in utero exposure. Previous studies have associated prenatal smoke exposure with reduced birth weight, poor developmental and psychological outcomes, and increased risk for diseases and behavioral disorders later in life. Researchers are now learning that many of the mechanisms whereby maternal smoke exposure may affect key pathways crucial for proper fetal growth and development are epigenetic in nature. Maternal cigarette smoking during pregnancy has been associated with altered DNA methylation and dysregulated expression of microRNA, but a deeper understanding of the epigenetics of maternal cigarette smoking during pregnancy as well as how these epigenetic changes may affect later health and behavior remain to be elucidated. This article seeks to explore many of the previously described epigenetic alterations associated with maternal cigarette smoking during pregnancy and assess how such changes may have consequences for both fetal growth and development, as well as later child health, behavior, and well-being. We also outline future directions for this new and exciting field of research.


PEDIATRICS ◽  
2000 ◽  
Vol 106 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Delia A. Dempsey ◽  
Beatrice Latal Hajnal ◽  
J. Colin Partridge ◽  
Sarah N. Jacobson ◽  
William Good ◽  
...  

PEDIATRICS ◽  
1994 ◽  
Vol 93 (2) ◽  
pp. 221-227 ◽  
Author(s):  
David L. Olds ◽  
Charles R. Henderson ◽  
Robert Tatelbaum

Objective. To examine the relationship between maternal cigarette smoking during pregnancy and children's intellectual functioning during the first 4 years of life. Design. Prospective follow-up of participants in a randomized trial of pregnancy and infancy nurse home visitation. Setting. Semirural community in Upstate New York. Participants. 400 families in which the mothers registered before the 30th week of pregnancy and had no previous live births. Eighty-five percent of the mothers were either teenagers (<19 years at registration), unmarried, or poor. Analysis limited to whites who comprised 89% of the sample. Main results. Children in the comparison group whose mothers smoked 10 or more cigarettes per day during pregnancy had Stanford-Binet scores at 3 and 4 years of age that were 4.35 (95% CI: 0.02, 8.68) points lower (after controlling for a wide range of variables) than their counterparts whose mothers did not smoke during pregnancy. Conclusions. The results of this study add to the increasingly consistent evidence that maternal cigarette smoking during pregnancy poses a unique risk for neurodevelopmental impairment among children and provide an additional reason for pregnant women not to smoke cigarettes.


Epigenetics ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Parisa Tehranifar ◽  
Hui-Chen Wu ◽  
Jasmine A. McDonald ◽  
Farzana Jasmine ◽  
Regina M. Santella ◽  
...  

2010 ◽  
Vol 12 (6) ◽  
pp. 658-664 ◽  
Author(s):  
T. R. Gray ◽  
R. D. Eiden ◽  
K. E. Leonard ◽  
G. Connors ◽  
S. Shisler ◽  
...  

1999 ◽  
Vol 150 (7) ◽  
pp. 683-694 ◽  
Author(s):  
S. Lieff ◽  
A. F. Olshan ◽  
M. Werler ◽  
R. P. Strauss ◽  
J. Smith ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document