Does Maternal Cigarette Smoking During Pregnancy Cause Cleft Lip and Palate in Offspring?

1989 ◽  
Vol 143 (3) ◽  
pp. 333 ◽  
Author(s):  
Muin J. Khoury
Keyword(s):  
Cigarette Smoking ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking

Maternal Cigarette Smoking During Pregnancy and the Risk of Having a Child With Cleft Lip/Palate

2000 ◽  
Vol 55 (9) ◽  
pp. 536-538
Author(s):  
Kevin C. Chung ◽  
Christine P. Kowalski ◽  
Hyungjin Myra Kim ◽  
Steven R. Buchman
Keyword(s):  
Cigarette Smoking ◽  
Cleft Lip ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking ◽  
Cleft Lip Palate

Maternal Cigarette Smoking during Pregnancy and the Risk of Having a Child with Cleft Lip/Palate

2000 ◽  
Vol 105 (2) ◽  
pp. 485-491 ◽  
Author(s):  
Kevin C. Chung ◽  
Christine P. Kowalski ◽  
Hyungjin Myra Kim ◽  
Steven R. Buchman
Keyword(s):  
Cigarette Smoking ◽  
Cleft Lip ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking ◽  
Cleft Lip Palate

Cigarette smoking as an etiologic factor in cleft lip and palate

1979 ◽  
Vol 135 (3) ◽  
pp. 348-351 ◽  
Author(s):  
Anders Ericson ◽  
Bengt Källén ◽  
Peter Westerholm
Keyword(s):  
Cigarette Smoking ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Etiologic Factor

Intellectual Impairment in Children of Women Who Smoke Cigarettes During Pregnancy

PEDIATRICS ◽  
1994 ◽  
Vol 93 (2) ◽  
pp. 221-227 ◽  
Author(s):  
David L. Olds ◽  
Charles R. Henderson ◽  
Robert Tatelbaum
Keyword(s):  
New York ◽  
Cigarette Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking ◽  
Upstate New York ◽  
Wide Range ◽  
Neurodevelopmental Impairment ◽  
The Relationship ◽  
Additional Reason

Objective. To examine the relationship between maternal cigarette smoking during pregnancy and children's intellectual functioning during the first 4 years of life. Design. Prospective follow-up of participants in a randomized trial of pregnancy and infancy nurse home visitation. Setting. Semirural community in Upstate New York. Participants. 400 families in which the mothers registered before the 30th week of pregnancy and had no previous live births. Eighty-five percent of the mothers were either teenagers (<19 years at registration), unmarried, or poor. Analysis limited to whites who comprised 89% of the sample. Main results. Children in the comparison group whose mothers smoked 10 or more cigarettes per day during pregnancy had Stanford-Binet scores at 3 and 4 years of age that were 4.35 (95% CI: 0.02, 8.68) points lower (after controlling for a wide range of variables) than their counterparts whose mothers did not smoke during pregnancy. Conclusions. The results of this study add to the increasingly consistent evidence that maternal cigarette smoking during pregnancy poses a unique risk for neurodevelopmental impairment among children and provide an additional reason for pregnant women not to smoke cigarettes.

scholarly journals Maternal cigarette smoking during pregnancy and offspring DNA methylation in midlife

Epigenetics ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Parisa Tehranifar ◽  
Hui-Chen Wu ◽  
Jasmine A. McDonald ◽  
Farzana Jasmine ◽  
Regina M. Santella ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cigarette Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking

Unraveling Human Cleft Lip and Palate Research

2008 ◽  
Vol 87 (2) ◽  
pp. 119-125 ◽  
Author(s):  
A.R. Vieira
Keyword(s):  
Statistical Power ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Current Knowledge ◽  
Missense Mutations ◽  
Definitive Evidence ◽  
Maternal Cigarette Smoking ◽  
Gene Environment ◽  
Functional Variant

The focus of this work is to highlight the most recent advances in the understanding of cleft lip and palate occurrence. Information regarding research on long-term outcomes, genes and their interactions with other genes, and gene-environment interactions is compiled to provide the reader with a critical and up-to-date overview on the current knowledge of the etiology of cleft lip and palate. Recent epidemiological evidence strongly suggests that individuals born with clefts have a shorter lifespan and may have a higher incidence of cancer and psychological disorders. IRF6 has been shown to be an important contributor to cleft lip and palate, but the functional variant leading to the defect has not yet been defined. Inactivation of MSX1 and genes in the FGF family has also been shown to lead to cleft lip and palate. In addition, missense mutations in several candidate genes may cause cleft lip and palate, but definitive evidence regarding the biological consequences of these mutations is yet to be unraveled. Maternal cigarette smoking increases the risk of a baby born with clefts, in particular when the mother carries the GSTT1-null variants. The latest approaches in cleft research include the analysis of several additional phenotypical features of the population, with the goal of increasing the statistical power of genetics studies.

scholarly journals Nicotine and metabolites in meconium as evidence of maternal cigarette smoking during pregnancy and predictors of neonatal growth deficits

2010 ◽  
Vol 12 (6) ◽  
pp. 658-664 ◽  
Author(s):  
T. R. Gray ◽  
R. D. Eiden ◽  
K. E. Leonard ◽  
G. Connors ◽  
S. Shisler ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Cigarette Smoking ◽  
Neonatal Growth

Interactions betweenRAD51rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate

2015 ◽  
Vol 170 (2) ◽  
pp. 536-539 ◽  
Author(s):  
Renato Assis Machado ◽  
Helenara Salvati Bertolossi Moreira ◽  
Sibele Nascimento de Aquino ◽  
Hercilio Martelli-Junior ◽  
Silvia Regina de Almeida Reis ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cigarette Smoking ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Maternal Cigarette Smoking
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