Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex

Neuroreport ◽  
1992 ◽  
Vol 3 (10) ◽  
pp. 916-918 ◽  
Author(s):  
Malcolm J. Sheardown
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Epileptiform Activity ◽  
Rat Cortex ◽  
Receptor Agonists ◽  
Metabotropic Glutamate ◽  
Glutamate Receptor Agonists

scholarly journals Metabotropic glutamate receptor agonists for schizophrenia

2008 ◽  
Vol 192 (2) ◽  
pp. 86-87 ◽  
Author(s):  
Paul J. Harrison
Keyword(s):  
Glutamate Receptors ◽  
Dopamine Receptor ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Blocking ◽  
Receptor Agonists ◽  
Metabotropic Glutamate ◽  
Glutamate Receptor Agonists

SummaryA drug acting at metabotropic glutamate receptors has recently been reported to be an effective antipsychotic, breaking the rule that only dopamine receptor-blocking drugs have this property. The finding complements accumulating evidence that glutamatergic abnormalities are important in the pathophysiology of schizophrenia.

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