The values of quantitative serum HIV-1 RNA levels and CD4 cell counts for predicting survival time among HIV-positive individuals with CD4 counts of ≤50×106 cells/l

AIDS ◽  
2000 ◽  
Vol 14 (9) ◽  
pp. 1147-1153 ◽  
Author(s):  
Eoin P. G. Coakley ◽  
Matthew H. Samore ◽  
Jacqueline M. Gillis ◽  
Michael D. Hughes ◽  
Scott M. Hammer
Keyword(s):  
Survival Time ◽  
Hiv Positive ◽  
Cd4 Counts ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Cd4 Cell ◽  
Hiv 1 ◽  
Rna Levels

scholarly journals The correlation of tuberculosis smear results and immuno-suppression with CD4+ counts as a surrogate marker among HIV infected patients.

2021 ◽  
Author(s):  
Kingsley Kamvuma ◽  
Yusuf ademola ◽  
Warren Chanda ◽  
Christopher Newton Phiri ◽  
Sam Bezza Phiri ◽  
...  
Keyword(s):  
Cell Count ◽  
Surrogate Marker ◽  
Hiv Positive ◽  
Sputum Smear ◽  
Cd4 Cell Count ◽  
Cd4 Counts ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Study Participants ◽  
Cd4 Cell

Abstract Background: Human immunodeficiency virus (HIV) and M.tuberculosis are two intracellular pathogens that interact at the cellular, clinical and population levels. Since the recognition of AIDS in 1981, the number of reported cases of TB in the has increased substantially, especially in regions with high incidence of AIDS. The main aim of this study was to establish weather there is a relationship between sputum smear positives and low CD4 cell counts among HIV infected patients.Materials and methods: This was a retrospective study involving 473 participants. The patients recruited in this study were those who tested HIV positive and smear positive for TB. Their HIV status was determined by performing an HIV blood test, if they were HIV positive their CD4 cell count were then made.Results: This study examined the relation between smear positivity and low CD4 (below 200cells/µl) together with CD8 and CD3 markers as a measure of immune function among patients infected with HIV. The study participants’ constituted males 67% and females 33%. The overall mean age was 33.2 (SD 6.9) with the youngest and oldest participants being 18 and 60 respectively. It was found that smear positive results negatively (r=-0.13; p=0.021) correlated with CD4+ below 200 cells/µl. No correlation was observed between smear positives and CD8+ or CD3+ since the calculated correlation coefficient was not significant 0.007 (p=0.9) and 0.03 (p=0.6) respectively. There are more 3+ smear results below 200 cells/µl than the others while above 200 cells/µl 1+ was the most commonly reported smear result. The scanty smear positives were the least commonly reported result in the low and high CD4 counts. Conclusion: The smear positive result negatively correlated with a low CD4+ (r=-0.13; p=0.021) but no correlation with low CD+8 and CD+3 results was observed. The long held theory that low bacillary counts in patients with low CD4+ counts needs to be revisited. The reduction of CD4+ cell count parallels' that of the total lymphocyte count and is more marked in patients with high bacillary counts. Further, studies are required to confirm these findings

scholarly journals Molecular Detection and Clinical Implications of HTLV-1 Infections among Antiretroviral Therapy-Naïve HIV-1-Infected Individuals in Abuja, Nigeria

2015 ◽  
Vol 6 ◽  
pp. VRT.S35331 ◽  
Author(s):  
Idris Abdullahi Nasir ◽  
Abdurrahman Elfulaty Ahmad ◽  
Anthony Uchenna Emeribe ◽  
Muhammad Sagir Shehu ◽  
Jessy Thomas Medugu ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Real Time ◽  
Biochemical Parameters ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cd4 Counts ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Special Clinic ◽  
Cd4 Cell ◽  
Hiv 1

Background Individuals with human T-cell lymphotrophic virus type-1 (HTLV-1)/HIV-1 coinfection have been demonstrated to undergo CD4+ lymphocytosis even in the face of immunodeficiency and increased vulnerability to opportunistic pathogens that can lead to poor prognosis. Objective This study investigated the prevalence as well as the effects of HIV-1/HTLV-1 coinfection on CD4+ cell counts, routine hematology, and biochemical parameters of study participants. Materials and Methods This prospective cross-sectional study involved 184 blood samples collected from HIV-1-seropositive individuals attending HIV-special clinic of the University of Abuja Teaching Hospital, Gwagwalada, Nigeria. These samples were analyzed for anti-HTLV-1/2 IgM antibodies using enzyme-linked immunosorbent assay, CD4+ cell counts, and some routine hematological and biochemical parameters. All samples were also tested for HTLV-1 provirus DNA using real-time polymerase chain reaction (PCR) assay. Results Of the 184 subjects studied, 9 (4.9%) were anti-HTLV-1/2 IgM seropositive; however, upon real-time PCR testing, 12 (6.5%) had detectable HTLV-1 provirus DNA. The CD4+ cell count was significantly high in HTLV-1-positive (742 ± 40.2) subjects compared to their HTLV-1-negative (380 ± 28.5) counterpart ( P-value = 0.025). However, there was no significant association between HTLV-1 positivity with other hematology and biochemical parameters studied ( P > 0.05). Conclusion All subjects (100%) who were HTLV-1/HIV-1-coinfected had normal CD4+ counts. This gives contrasting finding on the true extent of immunodeficiency of subjects. So it is suggested to be very careful in using only CD4+ counts to monitor disease progression and as indicators for antiretroviral therapy (ART) in resource-limited settings. In such conditions, there may be a need to test for HTLV-1 alongside HIV viral loads in order to begin appropriate ART regimens that contain both pathogens.

Trends in Post-Infection CD4 Cell Counts and Plasma HIV-1 RNA Levels in HIV-1-Infected Patients in France Between 1997 and 2005

2009 ◽  
Vol 52 (3) ◽  
pp. 422-426 ◽  
Author(s):  
Valérie Potard ◽  
Laurence Weiss ◽  
Franck Lamontagne ◽  
Elisabeth Rouveix ◽  
Geneviève Beck-Wirth ◽  
...  
Keyword(s):  
Post Infection ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Cd4 Cell ◽  
Hiv 1 ◽  
Rna Levels

Antiretroviral therapy interruption guided by CD4 cell counts and plasma HIV-1 RNA levels in chronically HIV-1-infected patients

AIDS ◽  
2007 ◽  
Vol 21 (2) ◽  
pp. 169-178 ◽  
Author(s):  
Lidia Ruiz ◽  
Roger Paredes ◽  
Guadalupe Gómez ◽  
Joan Romeu ◽  
Pere Domingo ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Therapy Interruption ◽  
Cd4 Cell ◽  
Hiv 1 ◽  
Rna Levels

scholarly journals Efavirenz‐Based Regimens in Treatment‐Naive Patients with a Range of Pretreatment HIV‐1 RNA Levels and CD4 Cell Counts

2008 ◽  
Vol 197 (7) ◽  
pp. 1006-1010 ◽  
Author(s):  
Heather J. Ribaudo ◽  
Daniel R. Kuritzkes ◽  
Christina M. Lalama ◽  
Jeffrey T. Schouten ◽  
Bruce R. Schackman ◽  
...  
Keyword(s):  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Treatment Naïve ◽  
Cd4 Cell ◽  
Hiv 1 ◽  
Rna Levels

The Relationship Between HIV Antibody Titer, HIV Viral Load, HIV p24 Antigen, and CD4 T-cell Count Among Iranian HIV-positive Patients

2020 ◽  
Vol 20 (5) ◽  
pp. 752-757
Author(s):  
Majedeh Moradbeigi ◽  
SeyedAhmad SeyedAlinaghi ◽  
Mansour Sajadipour ◽  
Omid Dadras ◽  
Esfandiar Shojaei ◽  
...  
Keyword(s):  
Viral Load ◽  
Cell Count ◽  
Venous Blood ◽  
Hiv Positive ◽  
Hiv Disease ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
P24 Antigen ◽  
Cd4 Cell ◽  
Hiv 1

Objective: This study aimed to simultaneously measure and assess the correlation between the available HIV infection parameters including HIV antibody, p24 Antigen, CD4 cell count, and viral load at the different stages of HIV disease among HIV-positive individuals in Iran. Materials and methods: Fifty HIV-positive individuals were classified into three stages (1, 2, and 3) according to the HIV disease stages classification, available in Control of Disease and Prevention (CDC) guideline. 10 ml of the venous blood sample was collected to run the tests for HIV antibody and p24 Ag levels, CD4 cell counts, and viral load. Pearson’s correlation test was employed to calculate the coefficients for the in-between correlation of different HIV parameters in each stage. Results: Of 50 participants, 17 (34%), 25 (50%), and 8 (16%) patients belonged to stages 1, 2, and 3, respectively. Sexual relationship was the main route of HIV transmission among the patients (36%); however, injecting drug use (20%) was also reported frequently. There was no significant correlation between the parameters of HIV disease in different stages in the present study. Conclusion: The findings showed no correlation between HIV parameters in the present study. Considering the fact that the association of HIV antibodies with HIV disease progression in infected individuals is independent of HIV-1 RNA levels, combined measurement of HIV-1 RNA and CD4 cell counts should be routinely carried out in HIV infected patients follow up.

scholarly journals Pattern of Maternal Group B Streptococcus (GBS) Colonization in Relation to CD4 Count among HIV Positive Women in Jos

2019 ◽  
pp. 1-6
Author(s):  
Dahal A. Samuel ◽  
Sabitu M. Zainu ◽  
Hosea S. Hamafyelto ◽  
Ille Mamman ◽  
Daniel Z. Egah ◽  
...  
Keyword(s):  
Pregnant Women ◽  
University Teaching ◽  
Colonization Rate ◽  
Hiv Positive ◽  
Cd4 Counts ◽  
Women Living With Hiv ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Cd4 Cell ◽  
Hiv Negative

Aim: The aim of this study was to determine the prevalence of GBS colonization among HIV positive and HIV negative pregnant women in relation to CD4 cell counts. Materials and Methodology: This was a hospital based descriptive cross-sectional study of 200 pregnant women (100 HIV positive and 100 HIV negative) and 100 non-pregnant women (50 HIV positive and 50 HIV negative) obtaining health care at the Jos University Teaching Hospital between July 2017 and November 2017. Systematic sampling technique and written informed consent were used in recruiting subjects for this study. High vaginal and anorectal swabs were collected from each subject after filling a structured questionnaire. CD4 cell count was also done for all the HIV positive patients at Aids Prevention Initiative in Nigeria (APIN) of Jos University Teaching Hospital (JUTH). The results from the laboratory analysis of the specimens were computed using SPSS version 21. Results: A colonization rate of 7.3% was observed in HIV positive patients compare to 5.3% in HIV negative. The different in colonization rate between the two groups was not statistically significant (X2 = 0.507; P = 0.477) (Table 1). In pregnant women living with HIV, colonization rate was 8.0% compare to 5.0% observed in non-pregnant women living with HIV. This however, was not statistically significant (Table 2) (χ2 = 0.013; P = 0.908). HIV positive subjects with low CD4 counts (<200 cells/μl) were observed to have high colonization rate (20.0%) than patients with high CD4 counts (≥500 cells/μl). Those with CD4 counts between 200-499 cells/μl had 8.1% colonization rate. These findings, though not statistically significant (Table 4) (χ2 = 1.3814; P = 0.2399), the increased colonization rate in low CD4 cell counts may be due to inability of the patient to mount immune response against the organism. Conclusion: There was no statistically significant difference in GBS colonization among HIV positive patients. A higher colonization rate was observed in HIV patients among the age group 21-25 years; ager was not significantly risk factor for GBS colonization in HIV patients. CD4 cell counts seem not to play any significant role in GBS colonization rate. Although, it was observed to be higher in patients with low CD4 cell counts; the different was not statistically significant.

Sign in / Sign up

Export Citation Format

Share Document