HIV transmission despite HIV post-exposure prophylaxis after non-occupational exposure

AIDS ◽  
2004 ◽  
Vol 18 (3) ◽  
pp. 582-584 ◽  
Author(s):  
Christiane Cordes ◽  
Arend Moll ◽  
Claudia Kuecherer ◽  
Ulrich Marcus
Keyword(s):  
Occupational Exposure ◽  
Hiv Transmission ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Exposure Prophylaxis

scholarly journals 986. Improvement in Administration of HIV Post-Exposure Prophylaxis in the Emergency Department Following Sexual Assault

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S521-S522
Author(s):  
Jennifer R Silva-Nash ◽  
Stacie Bordelon ◽  
Ryan K Dare ◽  
Sherrie Searcy
Keyword(s):  
Emergency Department ◽  
Sexual Assault ◽  
Hiv Transmission ◽  
Post Exposure Prophylaxis ◽  
Intervention Period ◽  
Post Intervention ◽  
Post Exposure ◽  
Assault Victims ◽  
Exposure Prophylaxis

Abstract Background Nonoccupational post exposure prophylaxis (nPEP) following sexual assault can prevent HIV transmission. A standardized Emergency Department (ED) protocol for evaluation, treatment, and follow up for post assault victims was implemented to improve compliance with CDC nPEP guidelines. Methods A single-center observational study of post sexual assault patients before/after implementation of an ED nPEP protocol was conducted by comparing the appropriateness of prescriptions, labs, and necessary follow up. A standardized order-set based on CDC nPEP guidelines, with involvement of an HIV pharmacist and ID clinic, was implemented during the 2018-2019 academic year. Clinical data from pre-intervention period (07/2016-06/2017) was compared to post-intervention period (07/2018-08/2019) following a 1-year washout period. Results During the study, 147 post-sexual assault patients (59 Pre, 88 Post) were included. One hundred thirty-three (90.4%) were female, 68 (46.6%) were African American and 133 (90.4%) were candidates for nPEP. Median time to presentation following assault was 12.6 hours. nPEP was offered to 40 (67.8%) and 84 (95.5%) patients (P< 0.001) and ultimately prescribed to 29 (49.2%) and 71 (80.7%) patients (P< 0.001) in pre and post periods respectively. Renal function (37.3% vs 88.6%; P< 0.001), pregnancy (39.0% vs 79.6%; P< 0.001), syphilis (3.4% vs 89.8%; P< 0.001), hepatitis B (15.3% vs 95.5%; P< 0.001) and hepatitis C (27.1% vs 94.3%) screening occurred more frequently during the post period. Labratory, nPEP Prescription and Follow up Details for Patients Prescribed nPEP Conclusion The standardization of an nPEP ED protocol for sexual assault victims resulted in increased nPEP administration, appropriateness of prescription, screening for other sexually transmitted infectious and scheduling follow up care. While guideline compliance dramatically improved, further interventions are likely warranted in this vulnerable population. Disclosures Ryan K. Dare, MD, MS, Accelerate Diagnostics, Inc (Research Grant or Support)

Post-exposure prophylaxis after non-occupational exposure to HIV in Greece

2008 ◽  
Vol 55 (1) ◽  
pp. 68-72 ◽  
Author(s):  
V. Raftopoulos ◽  
G. Nikolopoulos ◽  
V. Konte ◽  
M. Pylli ◽  
C. Tsiara ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Exposure Prophylaxis

Post-exposure prophylaxis

2002 ◽  
Vol 13 (1_suppl) ◽  
pp. 30-34 ◽  
Author(s):  
◽  
Marchina E Van Der Ende ◽  
Rosa M Regez ◽  
Gerrit Schreij ◽  
Jan T M Van Der Meer ◽  
...  
Keyword(s):  
The Netherlands ◽  
Hiv Transmission ◽  
Standard Procedure ◽  
High Plasma ◽  
Antiretroviral Drugs ◽  
Post Exposure Prophylaxis ◽  
Serious Adverse Events ◽  
Post Exposure ◽  
Occupational Setting ◽  
Exposure Prophylaxis

The mean risk of acquiring HIV after an occupational exposure, injecting drug use or sexual exposure varies from <0.1 to 3%. A high plasma HIV-RNA of the source increases the risk of each of the exposures. Other factors, such as the volume of the inoculum involved to which the individual was exposed, other sexually transmitted diseases and ruptures of mucous membranes are associated with a higher risk of HIV transmission. Based on the calculated risk, post-exposure prophylaxis (PEP) should be recommended. In the Netherlands, prescription of PEP in the occupational setting is a standard procedure and has proved to be feasible. This was associated with a high percentage (62%) of mild and reversible toxicity and a small percentage (2%) of serious adverse events related to antiretroviral drugs, i.e. nephrolithiasis (due to indinavir) and toxic hepatitis (due to nevirapine). In The Netherlands so far no HIV-seroconversions have been recorded after an occupational accident.

scholarly journals Post-exposure prophylaxis with a maraviroc-containing regimen after occupational exposure to a multi-resistant HIV-infected source person

2007 ◽  
Vol 80 (1) ◽  
pp. 9-10 ◽  
Author(s):  
Frédéric Méchai ◽  
Yann Quertainmont ◽  
Sabrinel Sahali ◽  
Jean-François Delfraissy ◽  
Jade Ghosn
Keyword(s):  
Occupational Exposure ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Exposure Prophylaxis

scholarly journals New UK guidance on post-exposure prophylaxis for HIV

2004 ◽  
Vol 8 (7) ◽  
Author(s):  
◽  
◽  
Keyword(s):  
United Kingdom ◽  
Occupational Exposure ◽  
Advisory Group ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
The United Kingdom ◽  
Expert Advisory ◽  
Exposure Prophylaxis ◽  
Expert Advisory Group

The United Kingdom (UK) Expert Advisory Group on AIDS (EAGA) has recently published revised guidelines on the use of post-exposure prophylaxis (PEP) for HIV following occupational exposure

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