Effect of Sucralfate and Basic Fibroblast Growth Factor on Fibrovascular Ingrowth into Hydroxyapatite and Porous Polyethylene Alloplastic Implants Using a Novel Rabbit Model

1997 ◽  
Vol 13 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Peter A.D. Rubin ◽  
Thilo E. Nicaeus ◽  
Michael A. Warner ◽  
Heidi D. Remulla
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Rabbit Model ◽  
Fibroblast Growth ◽  
Porous Polyethylene ◽  
Alloplastic Implants ◽  
Fibrovascular Ingrowth

Potential efficacy of basic fibroblast growth factor incorporated in biodegradable hydrogels for skull bone regeneration

1997 ◽  
Vol 86 (5) ◽  
pp. 871-875 ◽  
Author(s):  
Keisuke Yamada ◽  
Yasuhiko Tabata ◽  
Kazuo Yamamoto ◽  
Susumu Miyamoto ◽  
Izumi Nagata ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibrous Tissue ◽  
Rabbit Model ◽  
Fibroblast Growth ◽  
Skull Defect ◽  
Content Type

✓ Biodegradable gelatin hydrogels incorporating basic fibroblast growth factor (bFGF) were evaluated for their efficacy in bone regeneration using a rabbit model. Hydrogels with water contents of 85% and 98% were prepared using chemical crosslinking of gelatin with an isoelectric point of 4.9 in aqueous solution and, after freeze drying, were impregnated with an aqueous solution of bFGF to obtain bFGF-incorporated gelatin hydrogels. When they were implanted into bone defects measuring 6 mm in diameter in rabbit skulls (six animals/group), complete closure of the defect was observed at 12 weeks after implantation, regardless of the water content of the hydrogels. In contrast, bFGF did not enhance bone regeneration when applied to the skull defect in solution with phosphate-buffered saline (PBS). Also, gelatin hydrogels lacking bFGF were not effective in inducing bone formation, with fibrous tissue growing into the defect instead, similar to the skull defect seen in control rabbits treated with PBS. This indicates that the presence of hydrogels did not interfere with bone regeneration at the skull defect, probably because of their disappearance during biodegradation. It is concluded that the gelatin hydrogel is a promising matrix for effective induction of biological activity of bFGF for bone regeneration in skull and sinus defects.

scholarly journals Enhanced angiogenesis by gelatin hydrogels incorporating basic fibroblast growth factor in rabbit model of hind limb ischemia

2007 ◽  
Vol 22 (2) ◽  
pp. 104-108 ◽  
Author(s):  
Kazuhiko Doi ◽  
Tadashi Ikeda ◽  
Akira Marui ◽  
Toshihiro Kushibiki ◽  
Yoshio Arai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Hind Limb ◽  
Rabbit Model ◽  
Limb Ischemia ◽  
Fibroblast Growth ◽  
Hind Limb Ischemia

Vascular Regeneration by Repeated Infusions of Basic Fibroblast Growth Factor in a Rabbit Model of Hind-Limb Ischemia

2009 ◽  
Vol 192 (6) ◽  
pp. W306-W310 ◽  
Author(s):  
Ayumi Seko ◽  
Norihisa Nitta ◽  
Akinaga Sonoda ◽  
Shinichi Ohta ◽  
Masashi Takahashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Hind Limb ◽  
Rabbit Model ◽  
Limb Ischemia ◽  
Fibroblast Growth ◽  
Hind Limb Ischemia ◽  
Vascular Regeneration
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