THE SIDE-EFFECTS OF CLOZAPINE: A FOUR-YEAR FOLLOW-UP STUDY

1992 ◽  
Vol 15 ◽  
pp. 368B
Author(s):  
D. Marinković ◽  
I. Timotijevićm ◽  
T. Babinski ◽  
S. Totić ◽  
V. R. Paunović
Keyword(s):  
Author(s):  
Etsuo Murata ◽  
Kazutaka Tokita ◽  
Shigeyuki Tsurusaki ◽  
Hidetaka Murata

We have developed ethanol therapy for infectious atheroma based on the experience of two cases in which ethanol was injected into the liver cyst and the cyst shrank. For 64 infectious atheromas, atheroma contents were excreted and the cyst wall was contacted with 76% ethanol gauze for 5 minutes. Postoperatively, the cyst was washed daily as an open drainage. All cases were cured 10 days postoperatively, and no side effects. Postoperative follow up study results in 36 cases showed no recurrence in an average of 5 years. Pathological examination revealed koilocytosis in 14 of 25 cases (56%), which is considered to be an in direct finding of viral infection. The changes in human papillomavirus (HPV 16) before and after ethanol therapy in 25 cases using the Bi Digital O Ring Test (BDORT) decreased significantly from 10 26 ng (BDORT units) preoperatively to 1.6 ng (BDORT units) postoperatively. In also 12 cases follow up study without microscopy HPV 16 same decreased from 1064ng to 1.2 ng (BDORT unit) using BDORT with atheroma photographs. In total, HPV 16 could be demonstrated in 37 of 64 cases (57.8%) using BDOR T. Temporal changes of HPV 16 used for BDORT in 7 cases after contact with ethanol were inactivated after 3 minutes 30 seconds. The involvement of HPV 16 is suggested as the cause of atheroma. It is speculated that ethanol inactivated HPV 16 of atheroma, which stopped the turnover of the squamous epithelium and prevented recurrence. Ethanol therapy for infectious atheroma is useful as an original new one stage surgery because it is a simple procedure and has no side effects or recurrence.


1987 ◽  
Vol 150 (2) ◽  
pp. 175-179 ◽  
Author(s):  
C. Page ◽  
S. Benaim ◽  
F. Lappin

Patients suffering from unipolar and bipolar affective illness, who began treatment with prophylactic lithium carbonate during a 5-year period, were followed up and 59 out of 101 interviewed. Most had been taking lithium for at least 13 years: 49% had a complete remission, 41% a partial but significant response, and 10% no response. No specific individual or illness factor was found to correlate with favourable outcome, and no correlation between average serum lithium level and outcome. No side-effects could be associated specifically with the long-term use of lithium, but there was a surprisingly high incidence of clinical hypothyroidism.


2012 ◽  
Vol 36 (3) ◽  
pp. 629-636 ◽  
Author(s):  
Wiebke Kurre ◽  
Marta Aguilar Pérez ◽  
Diana Horvath ◽  
Elisabeth Schmid ◽  
Hansjörg Bäzner ◽  
...  

SLEEP ◽  
2017 ◽  
Vol 40 (suppl_1) ◽  
pp. A219-A220
Author(s):  
JA Uniken Venema ◽  
A Hoekema ◽  
M Doff

1987 ◽  
Vol 116 (2) ◽  
pp. 145-152 ◽  
Author(s):  
N.H. COX ◽  
S.K. JONES ◽  
D.J. DOWNEY ◽  
E.J. TUYP ◽  
J.L. JAY ◽  
...  

2011 ◽  
Vol 6 (1) ◽  
Author(s):  
Reinhard Huber ◽  
Herbert Braselmann ◽  
Hans Geinitz ◽  
Irene Jaehnert ◽  
Adolf Baumgartner ◽  
...  

1989 ◽  
Vol 7 (8) ◽  
pp. 1099-1104 ◽  
Author(s):  
G Stoter ◽  
A Koopman ◽  
C P Vendrik ◽  
A Struyvenberg ◽  
D T Sleyfer ◽  
...  

This 10-year follow-up study of 91 patients with disseminated testicular nonseminomatous cancer, treated with cisplatin, vinblastine, and bleomycin (PVB) induction chemotherapy and vinblastine plus bleomycin maintenance chemotherapy for a planned period of 2 years, shows a 63% cure rate. The predominant long-term sequelae are neurological and sexual dysfunction in 68% and 40% of patients, respectively. Two patients died of myocardial infarction. Sixteen percent of patients developed hypertension, 23% Raynaud's phenomenon, and 25% ototoxicity. Despite the long-term side effects, 90% of the patients who responded to a questionnaire are fully employed. This study shows that the maintenance chemotherapy has contributed to the incidence and/or degree of neurotoxicity, hypertension, and renal function disturbance.


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