Peak systolic pressure/end-systolic volume ratio, a load-independent measure of ventricular function, is reversibly decreased in human septic shock

1994 ◽  
Vol 22 (12) ◽  
pp. 1955-1959
Author(s):  
Margaret M. Parker ◽  
Frederick P. Ognibene ◽  
Joseph E. Parrillo
Keyword(s):  
Septic Shock ◽  
Ventricular Function ◽  
Systolic Pressure ◽  
Volume Ratio ◽  
Systolic Volume ◽  
Independent Measure ◽  
Human Septic Shock ◽  
End Systolic Volume

THE PEAK SYSTOLIC PRESSURE - END SYSTOLIC VOLUME RATIO CORRELATES WITH CHANGES IN THE EJECTION FRACTION IN A CANINE MODEL OF SEPTIC SHOCK

1987 ◽  
Vol 67 (3) ◽  
pp. A127-A127
Author(s):  
W. D. Hoffman ◽  
C. Natanson ◽  
R. L. Danner ◽  
T. J. MacVittie ◽  
R. I. Walker ◽  
...  
Keyword(s):  
Septic Shock ◽  
Ejection Fraction ◽  
Systolic Pressure ◽  
Volume Ratio ◽  
Canine Model ◽  
Systolic Volume ◽  
End Systolic Volume

Modification of force-interval relations during early adaptation to pressure overload in dogs

1987 ◽  
Vol 253 (6) ◽  
pp. H1506-H1513
Author(s):  
B. Crozatier ◽  
L. Hittinger ◽  
M. Chavance
Keyword(s):  
Ventricular Function ◽  
Systolic Pressure ◽  
Pressure Overload ◽  
Left Ventricular ◽  
Atrial Pacing ◽  
Force Frequency ◽  
Systolic Volume ◽  
Calculated Volume ◽  
End Systolic Volume ◽  
Ejection Pressure

Ventricular function was analyzed in the end-systolic and end-ejection pressure-volume diagrams in seven conscious dogs during acute aortic stenosis (AS) and sustained stenosis (SS) 24 h later. Dogs were previously instrumented with a left ventricular micromanometer and ultrasonic crystals measuring left ventricular major and minor axes and parietal wall thickness. The end-ejection pressure-calculated volume points were significantly shifted to the left during SS as compared with those obtained during AS both during a regular atrial pacing (150 beats/min) and during spontaneous heart rate. Postpacing beats were not different during AS and SS. During AS, end-systolic volume was larger after short intervals (SI) between beats (22.5 +/- 1.6 ml) than after long intervals (LI; 20.8 +/- 1.7 ml) for a smaller end-systolic pressure (P less than 0.001). This difference was minimal during SS. When SS was compared with AS, the end-systolic and end-ejection pressure-volume points were significantly shifted to the left after SI but not after LI. This suggests an acceleration of the restitution process during SS that modifies ventricular force-frequency relations and increases ventricular function as compared with AS, particularly for high heart rates.

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