scholarly journals Noninvasive measurement of the rest and exercise peak systolic pressure/end-systolic volume ratio: A sensitive two-dimensional echocardiographic indicator of left ventricular function

1984 ◽  
Vol 4 (3) ◽  
pp. 509-516 ◽  
Author(s):  
Leonard E. Ginzton ◽  
Michael M. Laks ◽  
Marianne Brizendine ◽  
Richard Conant ◽  
Ismael Mena
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Systolic Pressure ◽  
Volume Ratio ◽  
Left Ventricular ◽  
Noninvasive Measurement ◽  
Two Dimensional ◽  
Systolic Volume ◽  
End Systolic Volume ◽  
Rest And Exercise

Ketanserin Alone and in Combination with Enalapril in the Treatment of Essential Hypertension: Assessment of the Haemodynamic Effects

1993 ◽  
Vol 21 (3) ◽  
pp. 113-125
Author(s):  
O de Divitiis ◽  
M Galderisi ◽  
A Celentano ◽  
P Tammaro ◽  
M Garofalo ◽  
...  
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Haemodynamic Effects ◽  
Once Daily ◽  
Hypertensive Patients ◽  
Systolic Volume ◽  
End Diastolic Volume ◽  
End Systolic Volume ◽  
Blood Pressures

The antihypertensive and haemodynamic efficacies of ketanserin and ketanserin plus enalapril were compared. The monotherapy phase of the study involved the oral administration of 40 mg ketanserin twice daily or 20 mg enalapril once daily for 12 weeks to 25 hypertensive patients. Systolic and diastolic blood pressures were significantly reduced by both drugs. Left ventricular function both at rest and during effort improved significantly with either drug. This was due to a reduction of end-systolic volume; end-diastolic volume decreased only with the use of enalapril. Combination therapy, involving 16 patients and both drugs given at the original dosage schedule for 12 weeks, resulted in further reductions in systolic and diastolic blood pressures, and an improvement in left ventricular function; indices of diastolic function were not modified. In conclusion, ketanserin and enalapril showed comparable antihypertensive and haemodynamic activities. A combination of ketanserin and enalapril increased the favourable characteristics of both drugs.

Modification of force-interval relations during early adaptation to pressure overload in dogs

1987 ◽  
Vol 253 (6) ◽  
pp. H1506-H1513
Author(s):  
B. Crozatier ◽  
L. Hittinger ◽  
M. Chavance
Keyword(s):  
Ventricular Function ◽  
Systolic Pressure ◽  
Pressure Overload ◽  
Left Ventricular ◽  
Atrial Pacing ◽  
Force Frequency ◽  
Systolic Volume ◽  
Calculated Volume ◽  
End Systolic Volume ◽  
Ejection Pressure

Ventricular function was analyzed in the end-systolic and end-ejection pressure-volume diagrams in seven conscious dogs during acute aortic stenosis (AS) and sustained stenosis (SS) 24 h later. Dogs were previously instrumented with a left ventricular micromanometer and ultrasonic crystals measuring left ventricular major and minor axes and parietal wall thickness. The end-ejection pressure-calculated volume points were significantly shifted to the left during SS as compared with those obtained during AS both during a regular atrial pacing (150 beats/min) and during spontaneous heart rate. Postpacing beats were not different during AS and SS. During AS, end-systolic volume was larger after short intervals (SI) between beats (22.5 +/- 1.6 ml) than after long intervals (LI; 20.8 +/- 1.7 ml) for a smaller end-systolic pressure (P less than 0.001). This difference was minimal during SS. When SS was compared with AS, the end-systolic and end-ejection pressure-volume points were significantly shifted to the left after SI but not after LI. This suggests an acceleration of the restitution process during SS that modifies ventricular force-frequency relations and increases ventricular function as compared with AS, particularly for high heart rates.

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