Health Services: Concepts and Information for National Planning and Management: Experiences Based on the WHO/International Collaborative Study of Medical Care Utilization

1978 ◽  
Vol 3 (2) ◽  
pp. 94
Author(s):  
Mary Chatfield
Keyword(s):  
Health Services ◽  
Medical Care ◽  
Collaborative Study ◽  
Care Utilization ◽  
Medical Care Utilization ◽  
National Planning ◽  
Planning And Management ◽  
International Collaborative ◽  
International Collaborative Study

The Natural History of an International Collaborative Study of Medical Care Utilization

1966 ◽  
Vol 5 (4) ◽  
pp. 37-55 ◽  
Author(s):  
John H. Mabry ◽  
Ann Cartwright ◽  
Joyce Pearson ◽  
George Silver ◽  
Cedomir Vukmanovic
Keyword(s):  
Natural History ◽  
Medical Care ◽  
Collaborative Study ◽  
Care Utilization ◽  
Medical Care Utilization ◽  
History Of ◽  
International Collaborative ◽  
International Collaborative Study

An International Collaborative Study to Investigate Standardisation of Hirudin Potency

1993 ◽  
Vol 69 (05) ◽  
pp. 430-435 ◽  
Author(s):  
Colin Longstaff ◽  
Man-Yu Wong ◽  
Patrick J Gaffney
Keyword(s):  
Specific Activity ◽  
Collaborative Study ◽  
Residual Activity ◽  
Quality Standard ◽  
Upper Limit ◽  
Assay Procedure ◽  
Specific Activities ◽  
International Collaborative ◽  
Range Of Values ◽  
International Collaborative Study

SummaryAn international collaborative study has been carried out to investigate the reproducibility of hirudin assays in 13 laboratories using four recombinant hirudins and one natural, sulphated product. A simple assay procedure was proposed involving the titration of α-thrombin with inhibitor and measurement of residual activity using a chromogenic substrate. A standard α-thrombin preparation was supplied to ensure that this reagent was of uniform quality throughout the study. The method appeared to present no difficulties and laboratories reported similar potencies for the 5 hirudin samples, in line with expected values. This gave 200–222 Thrombin Inhibitory Units/ampoule (TIU/ampoule) of lyophilised hirudin, with geometric coefficient of variation (gcv) values ranging from 10.15–15.97%. This corresponds to specific activities of approximately 14,300–15,900 TIU/mg protein. This is close to the upper limit of previously reported values of specific activity. We conclude that the precision of this determination compared with the wider range of values in the literature (8,000–16,000 thrombin inhibitory units [TIU]/mg) results from the use of good quality standard α-thrombin by all laboratories. This study has important implications for hirudin standardisation.

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