The Role of Genetic Factors in Conduct Disorder Based on Studies of Tourette Syndrome and Attention-Deficit Hyperactivity Disorder Probands and Their Relatives

1995 ◽  
Vol 16 (3) ◽  
pp. 142???157 ◽  
Author(s):  
DAVID E. COMINGS
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Conduct Disorder ◽  
Tourette Syndrome ◽  
Attention Deficit ◽  
Genetic Factors ◽  
Hyperactivity Disorder

Genetic effects on the variation and covariation of attention deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (ODD/CD) symptomatologies across informant and occasion of measurement

2002 ◽  
Vol 32 (1) ◽  
pp. 39-53 ◽  
Author(s):  
T. S. NADDER ◽  
M. RUTTER ◽  
J. L. SILBERG ◽  
H. H. MAES ◽  
L. J. EAVES
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Conduct Disorder ◽  
Oppositional Defiant Disorder ◽  
Attention Deficit ◽  
Genetic Factors ◽  
Multiple Informants ◽  
Genetic Liability ◽  
Hyperactivity Disorder ◽  
Oppositional Defiant ◽  
Co Morbidity

Background. Previous studies have shown that the presence of conduct disorder may contribute to the persistence of attention deficit-hyperactivity disorder (ADHD) symptomatology into adolescence; however, the aetiological relationship between the two phenotypes remains undetermined. Furthermore, studies utilizing multiple informants have indicated that teacher ratings of these phenotypes are more valid than maternal reports.Methods. The genetic structure underlying the persistence of ADHD and oppositional-defiant disorder/conduct disorder (ODD/CD) symptomatologies as rated by mothers and teachers at two occasions of measurement was investigated on a sample of 494 male and 603 female same sex adolescent twin pairs participating in the Virginia Twin Study of Adolescent Behavioral Development (VTSABD).Results. Using structural modelling techniques, one common genetic factor was shown to govern the covariation between the phenotypes across informants and occasion of measurement with additional genetic factors specific to ODD/CD symptomatology and persistence of symptomatology at reassessment. Genetic structures underlying the phenotypes were, to some extent, informant dependent.Conclusions. The findings indicate that it is unlikely that the co-morbidity between ADHD and ODD/CD is due to environmental influences that are independent of ADHD. Rather it is likely to be due to a shared genetic liability either operating directly, or indirectly through gene–environment correlations or interactions. The covariation between phenotypes across informants and time is governed by a common set of genes, but it seems that ODD/CD is also influenced by additional genetic factors. Developmentally, different forms of genetic liability control ADHD in males and inattention in females.

scholarly journals Gene-Environment Interactions in Attention-Deficit/Hyperactivity Disorder Symptom Dimensions: The Role of Unhealthy Food Habits

Genes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 47
Author(s):  
Lin Li ◽  
Mark J. Taylor ◽  
Katarina Bälter ◽  
Tian Xie ◽  
Berit Skretting Solberg ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Food Intake ◽  
Attention Deficit ◽  
Genetic Factors ◽  
Dietary Habits ◽  
Unhealthy Food ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder ◽  
High Sugar

Background: Dietary habits were investigated as environmental risk factors for Attention-Deficit/Hyperactivity Disorder (ADHD). However, no previous studies explored the effects of dietary factors on modifying the role of genetic factors on ADHD. Methods: Based on a Swedish population-based twin study with 1518 twin pairs aged 20–47 years, we tested whether the importance of genetic and environmental effects on ADHD varied as a function of dietary habits. Self-reported dietary habits and ADHD symptoms were collected. Twin methods were used to test the degree to which high-sugar and unhealthy food intake moderated the genetic and environmental influences on ADHD symptoms. Results: In middle-aged adults, genetic influences on inattention symptoms were statistically significantly higher among individuals with higher levels of high-sugar (45%, 95%CI: 25–54%) and unhealthy food intake (51%, 95%CI: 31–60%), compared with those with lower levels of consumption of high-sugar (36%, 95%CI: 25–47%) and unhealthy foods (30%, 95%CI: 20–41%). Similar patterns were also found for the associations between hyperactivity/impulsivity and high-sugar/unhealthy food intake, even though the moderation effects were not statistically significant. Conclusion The present study suggests that genetic factors play a more prominent role in individual differences of ADHD symptoms in the presence of the high consumption of sugar and unhealthy foods. Future longitudinal studies with multiple assessments of ADHD and dietary habits are needed to replicate our findings.

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