Left ventricular diastolic function and responses to adrenergic stimuli in borderline arterial hypertension

Introduction. Arterial hypertension is a disease which has influence on the left ventricular diastolic function. It has been suggested that impairment of the left ventricular diastolic function in patients with diabetes mellitus is due to arterial hypertension and diffuse peripherial and coronary atherosclerosis which appear early in diabetic patients. Now, however, it is thought, that other mechanisms are responsable for the development of diabetic cardiomyopathy. The aim of the study was to investigate the effect of glycemia on the left ventricular diastolic function in patients with arterial hypertension. Methods. The study included 60 patients with arterial hypertension: 30 (50,00%) patients with diabetes mellitus and 30 (50,00%) with?out diabetes mellitus. The parameters of diastolic function were measured by the pulsed Doppler echocardiographic technique. Isovolumetric relaxation time, deceleration time, maximum velocity of the early stage of ventricular filling, maximum velocity of the late stage of ventricular filling and the early/late stage of ventricular filling ratio were used to assess the diastolic function. Results. The patients with arterial hypertension and diabetes mellitus compared to the patients with arterial hypertension without diabetes mellitus were significantly obese (p 0.001), had significantly higher glycemia (p<0.0001) and left atrial volume (p<0.05). The patients with arterial hypertension and diabetes mellilus compared to the patients with arterial hypertension without diabetes mellitus had significanllly: longer deceleration time (p< 0.05), lower velocity of early stage of ventricular filling (p<0.05) and lower early/late stage oj ventricular filling ratio (p<0.01). Conclusion. Diastolic function parameters of patients with diabetes mellitus are significantly changed: deceleration time is longer, early stage of ventricular filling and early/late ventricular filling ratio are lower.

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The impact of diabetes on left ventricular diastolic function in patients with arterial hypertension

Northern Clinics of Istanbul ◽

10.14744/nci.2015.55477 ◽

2016 ◽

Cited By ~ 2

Author(s):

Murat Araz

Keyword(s):

Arterial Hypertension ◽

Diastolic Function ◽

Left Ventricular Diastolic Function ◽

Left Ventricular ◽

Ventricular Diastolic Function ◽

The Impact

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Left atrial size in patients with arterial hypertension

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0604100m ◽

2006 ◽

Vol 134 (3-4) ◽

pp. 100-105 ◽

Cited By ~ 4

Author(s):

Suzana Milutinovic ◽

Svetlana Apostolovic ◽

Ivan Tasic

Keyword(s):

Arterial Hypertension ◽

Diastolic Function ◽

Left Atrial ◽

Left Ventricular Diastolic Function ◽

Left Ventricular ◽

Left Atrial Size ◽

Ventricular Diastolic Function ◽

Left Atrial Enlargement ◽

Atrial Size ◽

Atrial Enlargement

INTRODUCTION Left atrial size is increased in patients with arterial hypertension. Left atrial enlargement represents a risk factor of atrial fibrillation and stroke. Left atrial size depends on the effect of many other etiological factors, predominantly by body mass and the left ventricular mass. OBJECTIVE The objective of the study was to investigate the frequency of the left atrial enlargement in patients with arterial hypertension, in obese patients with arterial hypertension and in patients with arterial hypertension and left ventricular hypertrophy. In addition, the aim was to investigate the influence of diastolic function parameters on the left atrial dimension. METHOD The study included 93 patients with arterial hypertension (mean age of 46.9 ? 9.7 years, 50.5% of males) and 33 healthy subjects (mean age 45.6 ?10.6 yrs., 40% of males) who consisted the control group. There was no statistical difference of the age and sex between patients and healthy persons. All patients were examined by the echocardiographic ultrasound device HP Sonos 2500 by three echosonographers. RESULTS The patients with arterial hypertension compared to the control group had significantly higher: body mass index (27.8 ? 4.1 versus 24.3 ? 3.0) (p<0.001), the left ventricular mass (249.7 ? 79.1 versus 174.6 ? 47.7) (p<0,001), the left ventricular mass index (122.2 ? 34.3 versus 96.7 + 20.9)(p<0.001) and the left atrium (3.8 ? 0.7 versus 3.3 ? 0.5) (p<0.001). The frequency of the left atrial enlargement in patients with arterial hypertension was 44.1%. The frequency of the left atrial enlargement In patients with arterial hypertension and the left ventricular hypertrophy was 53.3%, and in obese patients with arterial hypertension was 58.3%. Left ventricular diastolic function parameters in patients with arterial hypertension in relation to control exhibited statistically significant differences: isovolumetric relaxation time (IVRT) was longer (193.2 ? 37.8 versus 175,8 ? 23,6) (p<0.001), deceleration time (DT) was longer (193.2 ?37,8 versus 175.8 ?23.6) (p<0.01) and peak early diastolic filling wave velocity /peak atrial diastolic filling wave velocity ratio (E/A ratio) was lower (1.0 ? 0.3 versus 1.2 ? 0.3) (p<0.01). The quotient of linear correlation of the left ventricular diastolic function parameters in patients with arterial hypertension with left atrial volume did not show any significant correlation. CONCLUSION The left atrial size was statistically bigger in patients with arterial hypertension in relation to healthy subjects. The biggest left atrial enlargement was in hypertensive patients with the left ventricular hypertrophy and obese hypertensive patients. Left ventricular diastolic function parameters in patients with arterial hypertension had no statistically significant influence on the left atrial size.

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