Contribution of blood pressure variability to the effect of nitrendipine on end-organ damage in spontaneously hypertensive rats

2003 ◽  
Vol 21 (10) ◽  
pp. 1961-1967 ◽  
Author(s):  
Jian-Guo Liu ◽  
Li-Ping Xu ◽  
Zheng-Xu Chu ◽  
Chao-Yu Miao ◽  
Ding-Feng Su
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Organ Damage ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
End Organ Damage

Relationship between baroreceptor reflex function and end-organ damage in spontaneously hypertensive rats

1999 ◽  
Vol 277 (3) ◽  
pp. H1200-H1206 ◽  
Author(s):  
Zheng-Zheng Shan ◽  
Sheng-Ming Dai ◽  
Ding-Feng Su
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spontaneously Hypertensive Rats ◽  
Organ Damage ◽  
Baroreceptor Reflex ◽  
Hypertensive Rats ◽  
Baroreceptor Sensitivity ◽  
Spontaneously Hypertensive ◽  
End Organ Damage ◽  
Wistar Kyoto

The purpose of this study was to further illustrate the relationship between baroreceptor reflex sensitivity (BRS) and hypertensive end-organ damage (EOD) and to test the hypothesis that impairment of BRS aggravates EOD in hypertension. We studied baroreflex-mediated changes in heart rate [expressed as baroreceptor sensitivity to heart rate control (BRSHR)] and blood pressure [expressed as baroreceptor sensitivity to blood pressure control (BRSBP)] in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) that were used as controls, both at the age of 50–52 wk. Rats were also instrumented to record BP, HR, and BP variability (BPV) in the conscious, unrestrained state. In SHR compared with WKY, BP and BPV were significantly increased, whereas BRSHR and BRSBP were significantly decreased. SHR had remarkable EOD when compared with WKY (EOD score: 6.3 ± 2.5 vs. 2.9 ± 0.8, P < 0.01). Univariate regressive analysis demonstrated that EOD score was increased with BP and BPV and decreased with BRS. In multivariate analysis, EOD score was predicted by greater systolic BP and lower BRS and HR variability. These results indicate that BRS is negatively related to BPV and EOD score, and impaired BRS might be one of the major causes for hypertensive EOD.

Effects of low-dose ketanserin on blood pressure variability, baroreflex sensitivity and end-organ damage in spontaneously hypertensive rats

2005 ◽  
Vol 108 (6) ◽  
pp. 547-552 ◽  
Author(s):  
He-Hui XIE ◽  
Fu-Ming SHEN ◽  
Yong-Bing CAO ◽  
Hui-Lin LI ◽  
Ding-Feng SU
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Baroreflex Sensitivity ◽  
Low Dose ◽  
Organ Damage ◽  
Left Ventricular ◽  
Hypertensive Rats ◽  
Organ Protection ◽  
Spontaneously Hypertensive

The present study was designed to investigate the effects of low-dose ketanserin on BPV (blood pressure variability), BRS (baroreflex sensitivity) and organ damage in SHR (spontaneously hypertensive rats). Ketanserin was mixed in rat chow at an estimated dose of 0.1 mg·kg−1 of body weight·day−1. SHR were treated for 4 months. BP (blood pressure) was then recorded continuously for 24 h in a conscious state. After determination of BRS, rats were killed for organ damage evaluation. It was found that long-term treatment with low-dose ketanserin did not lower BP levels, but significantly decreased BPV, enhanced BRS and reduced organ damage in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was most closely correlated (or associated) with the increase in BRS, whereas the decrease in aortic hypertrophy was most closely associated with the decrease in diastolic BPV and the amelioration in renal lesion, with the increase in BRS and the decrease in diastolic BPV. In conclusion, low-dose ketanserin produces organ protection independently of its BP-lowering action in SHR, and this organ protection was importantly attributable to the enhancement of BRS and decrease in BPV.

scholarly journals Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Bo Li ◽  
Zheng-Biao Yang ◽  
Shan-Shan Lei ◽  
Jie Su ◽  
Min-Xia Pang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Hypertensive Rats ◽  
Short Term ◽  
Spontaneously Hypertensive ◽  
Radix Paeoniae Alba

Blood pressure variability (BPV) is associated with the development and progression of severe target organ damage (TOD). This study aims to evaluate the protective effect of paeoniflorin enriched extract from Radix Paeoniae Alba (PG) on BPV and TOD in spontaneously hypertensive rats (SHR). All SHR were orally treated with distilled water, metoprolol (MP, 20 mg/kg), and PG (PG-H, 90 mg/kg or PG-L, 30 mg/kg) for a single time or daily for 7 weeks. The 24-hour dynamic blood pressure was monitored and then calculated BPV including long- and short-term systolic blood pressure variability (SBPV), diastolic blood pressure variability (DBPV), mean blood pressure variability (MBPV), and heart rate variability (HRV) as well as the 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP. The protective effects of PG on TOD were observed by histopathologic and biochemical detection. The results indicated that long- and short-term SBPV, DBPV, MBPV, and HRV as well as 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP showed no significant changes after single-dose administration of PG and significantly decreased after administration with PG for 7 weeks. PG could also markedly improve the damage of aorta, heart, kidney, and brain. This study suggested that PG could notably reduce BPV, stabilize blood pressure, and mitigate TOD in SHR.

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