NON HIGH DENSITY LIPOPROTEIN CHOLESTEROL IS MORE STRONGLY ASSOCIATED TO CAROTID PLAQUES THAN LDL CHOLESTEROL IN AN ITALIAN HYPERTENSIVE POPULATION

Background and Purpose: Lipid levels are established risk factors for ischemic heart disease, but uncertainty persists about the relevance of lipids for first ischemic stroke (IS). The goal of this study was to evaluate whether lipid profiles are risk factors for first IS in a Chinese hypertensive population. Methods: Our study population was selected from 300,000 individuals registered from 2016-2018 in the Lianyungang and Rongcheng “H-type hypertension prevention and control public service project”. Hypertensive patients with stroke data from the Chinese centers for disease control and prevention (CDC, 2013-2018) who had complete records (physical exam, questionnaire, and biological samples) were selected as cases. We used a nested case-control study design and matched 3615 ischemic stroke cases with an equal number of controls (hypertensive patients without stroke) for age±1 years, sex, and village. The crude and adjusted risks of first ischemic stroke were estimated by ORs and 95% CIs using conditional logistic regression, with or without adjustment for pertinent covariates. Results: Participants with first IS had higher blood pressure, body mass index, fasting glucose, triglycerides, and low-density lipoprotein cholesterol. High-density lipoprotein cholesterol (HDL-C) was significantly and inversely associated with IS risk (OR, 0.71; 95% CI: 0.61-0.82). When HDL was assessed as quartiles, the lowest quartile was used as reference, a significantly lower risk for IS was found in the highest quartile (HDL-C ≥ 1.8mmol/L: OR, 0.70; 95% CI: 0.59-0.82). There was a significant positive association between TG and the risk of IS (per SD increment; OR, 1.13; 95% CI, 1.07-1.20). Consistently, a significantly higher risk of first IS was found in quartile 4 (≥1.8 mmol/L: OR, 1.41; 95% CI, 1.20-1.65) compared with those in quartile 1 (<0.9 mmol/L). Conclusions: HDL-C levels inversely associated with first IS. These results differ from existing evidence from western populations, highlighting potential differences in Chinese populations. These differences can be attributed to multiple factors, including genetics, diet and lifestyle and call for further study to investigate potential explanatory mechanisms.

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U-Shaped Association of High-Density Lipoprotein Cholesterol with All-Cause and Cardiovascular Mortality in Hypertensive Population

Risk Management and Healthcare Policy ◽

10.2147/rmhp.s272624 ◽

2020 ◽

Vol Volume 13 ◽

pp. 2013-2025

Author(s):

Chao-lei Chen ◽

Xiaocong Liu ◽

Lin Liu ◽

Kenneth Lo ◽

Yuling Yu ◽

...

Keyword(s):

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Cardiovascular Mortality ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Hypertensive Population

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The U-Shaped Association of Non-High-Density Lipoprotein Cholesterol Levels With All-Cause and Cardiovascular Mortality Among Patients With Hypertension

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.707701 ◽

2021 ◽

Vol 8 ◽

Author(s):

Qi Cheng ◽

Xiao-cong Liu ◽

Chao-lei Chen ◽

Yu-qing Huang ◽

Ying-qing Feng ◽

...

Keyword(s):

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Cardiovascular Mortality ◽

Cox Regression ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Lipid Lowering ◽

Hypertensive Population ◽

All Cause Mortality

Background: Non-high-density lipoprotein cholesterol (non-HDL-C) is a valuable indicator in routine blood lipid tests, but the associations of non-HDL-C with mortality in hypertensive population still remain uncertain.Methods: In the National Health and Nutrition Examination Surveys from 1999 to 2014, participants having hypertension were included and grouped by non-HDL-C levels (<130, 130–159, 160–189, 190–219, and ≥220 mg/dl). Multivariate Cox regression was conducted for calculation of hazard ratios (HR) and 95% confidence interval (CI). To reveal the relationship between non-HDL-C and mortality, Kaplan–Meier survival curves, restricted cubic spline, linear regression, and subgroup analysis were also applied.Results: A total of 12,169 participants (47.52% males, mean age 57.27 ± 15.79 years) were included. During average follow-up of 92.5 months, 1,946 (15.99%) all-cause deaths and 422 (3.47%) cardiovascular deaths occurred. After adjusting for confounders, the association of non-HDL-C with mortality was detected as U-shaped. Threshold values were observed at 158 mg/dl for all-cause mortality and 190 mg/dl as to cardiovascular mortality. Below the threshold, every 10 mg/dl increment in non-HDL-C attributed to relatively low all-cause mortality significantly (HR = 0.94, 95% CI: 0.92–0.96). Above the threshold, non-HDL-C has significant positive associations with both all-cause (HR = 1.03, 95% CI: 1.01–1.05) and cardiovascular mortality (HR = 1.09, 95% CI: 1.05–1.14). For subgroups analysis, similar results were found among participants age <65 years old, non-white population, those were not taking lipid-lowering drugs, and subjects with body mass index (BMI) ≥25 kg/m2.Conclusion: The U-shaped association was detected between non-HDL-C and mortality among hypertensive population.

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High-Density Lipoprotein Cholesterol and the Risk of First Ischemic Stroke in a Chinese Hypertensive Population

Clinical Interventions in Aging ◽

10.2147/cia.s295252 ◽

2021 ◽

Vol Volume 16 ◽

pp. 801-810

Author(s):

Yue Zhang ◽

Jingyi Li ◽

Chengzhang Liu ◽

Hongxiang Yu ◽

Chen Chen ◽

...

Keyword(s):

Ischemic Stroke ◽

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Hypertensive Population

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Contribution of Nontraditional Lipid Profiles to Hyperuricemia in a Hypertensive Population: Findings from the China Hypertension Registry Study

10.21203/rs.3.rs-92273/v1 ◽

2020 ◽

Author(s):

Yu Yu ◽

Wangsheng Fang ◽

Dandan Wang ◽

Yu Tao ◽

Minghui Li ◽

...

Keyword(s):

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Multivariate Logistic Regression Analysis ◽

Density Lipoprotein ◽

Lipid Profiles ◽

High Density ◽

Lipoprotein Cholesterol ◽

Lipid Lowering ◽

Hypertensive Population ◽

The Relationship

Abstract Background: Current studies support nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL -C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C)] as reliable indicators of cardiovascular disease, stroke and diabetes. However, whether nontraditional lipid profiles can be used as reliable markers for hyperuricemia (HUA) remains unclear due to limited research. The present study investigated the relationship of nontraditional lipid profiles with HUA in hypertensive patients.Methods: We analyzed data from 13,721 Chinese hypertensive population untreated with lipid-lowering drugs. The relationship between non-traditional lipid profiles and HUA was examined by multivariate logistic regression analysis and smooth curve fitting (penalized spline method).Results: The results showed that there were positive associations of TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C with HUA, respectively (all P <0.001). Furthermore, nontraditional lipid profiles were converted from continuous variables to tertiles. Compared with lowest tertile, the multivariate adjusted ORs (95% CI) of TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio and non-HDL-C in highest tertile were 1.79 (1.62, 1.99), 2.09 (1.88, 2.32), 1.67 (1.51, 1.86), 1.93 (1.74, 2.13), respectively (all P <0.001).Conclusions: In Chinese hypertensive population, there were positive associations between nontraditional lipid profiles (TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio, and non-HDL-C) and HUA. Our findings further expand the scope of application of nontraditional lipid profiles. These novel and important results suggest that nontraditional lipid profiles can be used as potential and valuable indicators of HUA, and provide a new strategy for the prevention and treatment of HUA.

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Triglyceride to high density lipoprotein cholesterol ratio, total cholesterol to high density lipoprotein cholesterol ratio and low ankle brachial index in an elderly population

VASA ◽

10.1024/0301-1526/a000348 ◽

2014 ◽

Vol 43 (3) ◽

pp. 189-197 ◽

Cited By ~ 10

Author(s):

Yiqiang Zhan ◽

Jinming Yu ◽

Rongjing Ding ◽

Yihong Sun ◽

Dayi Hu

Keyword(s):

High Density Lipoprotein ◽

Total Cholesterol ◽

High Density Lipoprotein Cholesterol ◽

Ankle Brachial Index ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Lipid Lowering ◽

Cholesterol Ratio ◽

Potential Biomarker

Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, and low-density lipoprotein cholesterol (LDL-C) were assessed in all participants. Low ABI was defined as ABI ≤ 0.9 in either leg. Multiple logistic regression models were applied to study the association between TG/HDL‑C ratio, TC/HDL‑C ratio and low ABI. Results: The TG/HDL‑C ratios for those with ABI > 0.9 and ABI ≤ 0.9 were 1.28 ± 1.20 and 1.48 ± 1.13 (P < 0.0001), while the TC/HDL‑C ratios were 3.96 ± 1.09 and 4.32 ± 1.15 (P < 0.0001), respectively. After adjusting for age, gender, body mass index, obesity, current drinking, physical activity, hypertension, diabetes, lipid-lowering drugs, and cardiovascular disease history, the odds ratios (ORs) with 95 % confidence intervals (CIs) of low ABI for TG/HDL‑C ratio and TC/HDL‑C ratio were 1.10 (0.96, 1.26) and 1.34 (1.14, 1.59) in non-smokers. When TC was further adjusted, the ORs (95 % CIs) were 1.40 (0.79, 2.52) and 1.53 (1.21, 1.93) for TG/HDL‑C ratio and TC/HDL‑C ratio, respectively. Non-linear relationships were detected between TG/HDL‑C ratio and TC/HDL‑C ratio and low ABI in both smokers and non-smokers. Conclusions: TC/HDL‑C ratio was significantly associated with low ABI in non-smokers and the association was independent of TC, TG, HDL‑C, and LDL-C. TC/HDL‑C might be considered as a potential biomarker for early peripheral arterial disease screening.

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