Proarrhythmic Effects of DL- and D-Sotalol on the "Border Zone" Between Normal and Ischemic Regions of Isolated Ventricular Myocardium and Antiarrhythmic Effects on Reperfusion

1998 ◽  
Vol 31 (1) ◽  
pp. 126-139 ◽  
Author(s):  
Sandra Picard ◽  
René Rouet ◽  
Francesco Monti ◽  
Paolo Emilio Puddu ◽  
Pierre Ducouret ◽  
...  
Keyword(s):  
Ventricular Myocardium ◽  
Border Zone ◽  
Antiarrhythmic Effects

scholarly journals Antiarrhythmic effects of alpha-adrenoceptor antagonists in guinea pig ventricular myocardium

1988 ◽  
Vol 12 (6) ◽  
pp. 1590-1598 ◽  
Author(s):  
Junichi Hasegawa ◽  
Shozo Hirai ◽  
Makoto Saitoh ◽  
Hiroshi Kotake ◽  
Hiroto Mashiba
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocardium ◽  
Alpha Adrenoceptor ◽  
Antiarrhythmic Effects

IKs blockade in border zone arrhythmias from guinea-pig ventricular myocardium submitted to simulated ischemia and reperfusion

2011 ◽  
Vol 26 (4) ◽  
pp. 445-453 ◽  
Author(s):  
Paolo Emilio Puddu ◽  
Laurent Sallé ◽  
Jean-Louis Gérard ◽  
René Rouet ◽  
Joffrey Ducroq
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocardium ◽  
Border Zone ◽  
Ischemia And Reperfusion ◽  
Simulated Ischemia

scholarly journals Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics

2021 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Adwiteeya Misra ◽  
Cameron D. Baker ◽  
Elizabeth M. Pritchett ◽  
Kimberly N. Burgos Villar ◽  
John M. Ashton ◽  
...  
Keyword(s):  
Ventricular Myocardium ◽  
Metabolic Reprogramming ◽  
Border Zone ◽  
Neonatal Heart ◽  
Heart Repair ◽  
Fibrotic Scar ◽  
Secretory Phenotype ◽  
Matrix Production ◽  
Scar Resolution ◽  
Insight Into

The neonatal mammalian heart exhibits a remarkable regenerative potential, which includes fibrotic scar resolution and the generation of new cardiomyocytes. To investigate the mechanisms facilitating heart repair after apical resection in neonatal mice, we conducted bulk and spatial transcriptomic analyses at regenerative and non-regenerative timepoints. Importantly, spatial transcriptomics provided near single-cell resolution, revealing distinct domains of atrial and ventricular myocardium that exhibit dynamic phenotypic alterations during postnatal heart maturation. Spatial transcriptomics also defined the cardiac scar, which transitions from a proliferative to secretory phenotype as the heart loses regenerative potential. The resolving scar is characterized by spatially and temporally restricted programs of inflammation, epicardium expansion and extracellular matrix production, metabolic reprogramming, lipogenic scar extrusion, and cardiomyocyte restoration. Finally, this study revealed the emergence of a regenerative border zone defined by immature cardiomyocyte markers and the robust expression of Sprr1a. Taken together, our study defines the spatially and temporally restricted gene programs that underlie neonatal heart regeneration and provides insight into cardio-restorative mechanisms supporting scar resolution.

“Channeling” the powers of God’s Word

2010 ◽  
Vol 4 (2) ◽  
pp. 135-156 ◽  
Author(s):  
Dorothea E. Schulz
Keyword(s):  
The Other ◽  
Border Zone ◽  
Focus Attention ◽  
Spiritual Power ◽  
New Materials ◽  
God's Word ◽  
Audio Recordings ◽  
Heated Debate ◽  
The Subject ◽  
The One

Starting with the controversial esoteric employment of audio recordings by followers of the charismatic Muslim preacher Sharif Haidara in Mali, the article explores the dynamics emerging at the interface of different technologies and techniques employed by those engaging the realm of the Divine. I focus attention on the “border zone” between, on the one hand, techniques for appropriating scriptures based on long-standing religious conventions, and, on the other, audio recording technologies, whose adoption not yet established authoritative and standardized forms of practice, thereby generating insecurities and becoming the subject of heated debate. I argue that “recyclage” aptly describes the dynamics of this “border zone” because it captures the ways conventional techniques of accessing the Divine are reassessed and reemployed, by integrating new materials and rituals. Historically, appropriations of the Qur’an for esoteric purposes have been widespread in Muslim West Africa. These esoteric appropriations are at the basis of the considerable continuities, overlaps and crossovers, between scripture-related esoteric practices on one side, and the treatment by Sharif Haidara’s followers of audio taped sermons as vessels of his spiritual power, on the other.

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