Effect of Reserpine Treatment on Low-Density Lipoproteins in Arterial Wall and Internal Organs of Rats

2000 ◽  
Vol 35 (5) ◽  
pp. 686-692 ◽  
Author(s):  
Shahida Shafi ◽  
Dieter Welzel ◽  
Gottfried Weidinger ◽  
Jonathan Brown ◽  
Gustav Victor Rudolf Born
Keyword(s):  
Arterial Wall ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Internal Organs ◽  
Reserpine Treatment

scholarly journals Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xueping Chen ◽  
Jian Zhuang ◽  
Huanlei Huang ◽  
Yueheng Wu
Keyword(s):  
Shear Stress ◽  
Coronary Artery ◽  
Left Coronary Artery ◽  
Arterial Wall ◽  
Low Density Lipoproteins ◽  
Patient Specific ◽  
Low Density ◽  
Fluid Structure ◽  
Flowing Blood ◽  
Stress Dependent

AbstractThe purpose of this study is to compare the effect of the different physical factors on low-density lipoproteins (LDL) accumulation from flowing blood to the arterial wall of the left coronary arteries. The three-dimensional (3D) computational model of the left coronary arterial tree is reconstructed from a patient-specific computed tomography angiography (CTA) image. The endothelium of the coronary artery is represented by a shear stress dependent three-pore model. Fluid–structure interaction ($$FSI$$ FSI ) based numerical method is used to study the LDL transport from vascular lumen into the arterial wall. The results show that the high elastic property of the arterial wall decreases the complexity of the local flow field in the coronary bifurcation system. The places of high levels of LDL uptake coincide with the regions of low wall shear stress. In addition, hypertension promotes LDL uptake from flowing blood in the arterial wall, while the thickened arterial wall decreases this process. The present computer strategy combining the methods of coronary CTA image 3D reconstruction, $$FSI$$ FSI simulation, and three-pore modeling was illustrated to be effective on the simulation of the distribution and the uptake of LDL. This may have great potential for the early prediction of the local atherosclerosis lesion in the human left coronary artery.

scholarly journals Low Density Lipoproteins Downregulate Lysyl Oxidase in Vascular Endothelial Cells and the Arterial Wall

2002 ◽  
Vol 22 (9) ◽  
pp. 1409-1414 ◽  
Author(s):  
Cristina Rodríguez ◽  
Berta Raposo ◽  
José Martínez-González ◽  
Laura Casaní ◽  
Lina Badimon
Keyword(s):  
Endothelial Cells ◽  
Arterial Wall ◽  
Vascular Endothelial Cells ◽  
Lysyl Oxidase ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Vascular Endothelial

scholarly journals Accumulation of native and methylated low density lipoproteins by healing rabbit arterial wall.

1987 ◽  
Vol 7 (4) ◽  
pp. 361-366 ◽  
Author(s):  
A J Fischman ◽  
A M Lees ◽  
R S Lees ◽  
M Barlai-Kovach ◽  
H W Strauss
Keyword(s):  
Arterial Wall ◽  
Low Density Lipoproteins ◽  
Low Density

Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall

2019 ◽  
Vol 26 (9) ◽  
pp. 1701-1710 ◽  
Author(s):  
Katariina Öörni ◽  
Satu Lehti ◽  
Peter Sjövall ◽  
Petri T. Kovanen
Keyword(s):  
Arterial Wall ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Lipoprotein Particles ◽  
Atherosclerotic Lesions ◽  
Remnant Lipoproteins

Apolipoprotein B –containing lipoproteins include triglyceride-rich lipoproteins (chylomicrons and their remnants, and very low-density lipoproteins and their remnants) and cholesterol-rich low-density lipoprotein particles. Of these, lipoproteins having sizes below 70-80 nm may enter the arterial wall, where they accumulate and induce the formation of atherosclerotic lesions. The processes that lead to accumulation of lipoprotein-derived lipids in the arterial wall have been largely studied with a focus on the low-density lipoprotein particles. However, recent observational and genetic studies have discovered that the triglyceriderich lipoproteins and their remnants are linked with cardiovascular disease risk. In this review, we describe the potential mechanisms by which the triglyceride-rich remnant lipoproteins can contribute to the development of atherosclerotic lesions, and highlight the differences in the atherogenicity between low-density lipoproteins and the remnant lipoproteins.

DIFFERENCES IN THE STRUCTURE OF PLASMA LOW-DENSITY LIPOPROTEINS AND THEIR RELATIONSHIP TO THE EXTENT OF INTERACTION WITH ARTERIAL WALL COMPONENTS

1976 ◽  
Vol 275 (1 Atherogenesis) ◽  
pp. 153-168 ◽  
Author(s):  
Germán Camejo ◽  
Salvador Waich ◽  
Leonardo Mateu ◽  
Harry Acquatella ◽  
Fernando Lalaguna ◽  
...  
Keyword(s):  
Arterial Wall ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Wall Components

scholarly journals Selective accumulation of low density lipoproteins in damaged arterial wall.

1983 ◽  
Vol 24 (9) ◽  
pp. 1160-1167
Author(s):  
A B Roberts ◽  
A M Lees ◽  
R S Lees ◽  
H W Strauss ◽  
J T Fallon ◽  
...  
Keyword(s):  
Arterial Wall ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Selective Accumulation
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