Increase in Neurogenic Nitric Oxide Metabolism by Endothelin-1 in Mesenteric Arteries from Hypertensive Rats

2000 ◽  
Vol 36 (5) ◽  
pp. 541-547 ◽  
Author(s):  
Mercedes Ferrer ◽  
M Jesús Alonso ◽  
Mercedes Salaices ◽  
Jesús Marín ◽  
Gloria Balfagón
Keyword(s):  
Nitric Oxide ◽  
Mesenteric Arteries ◽  
Hypertensive Rats ◽  
Endothelin 1 ◽  
Nitric Oxide Metabolism

Angiotensin II increases neurogenic nitric oxide metabolism in mesenteric arteries from hypertensive rats

Life Sciences ◽  
2001 ◽  
Vol 68 (10) ◽  
pp. 1169-1179 ◽  
Author(s):  
Mercedes Ferrer ◽  
M Jesús Alonso ◽  
Mercedes Salaices ◽  
Jesús Marı́n ◽  
Gloria Balfagón
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Mesenteric Arteries ◽  
Hypertensive Rats ◽  
Nitric Oxide Metabolism

Endothelin-1 May Be a Potential Biomarker for Monitoring Changes in Nitric Oxide Metabolism in Pulmonary Hypertension

2020 ◽  
Vol 26 (10) ◽  
pp. S17-S18
Author(s):  
Adil Yunis ◽  
Mehdi Nouraie ◽  
Noel Britton ◽  
Yingze Zhang ◽  
Nicole Helbling ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Endothelin 1 ◽  
Nitric Oxide Metabolism ◽  
Potential Biomarker

Increased vascular endothelin-1 gene expression with unaltered nitric oxide synthase levels in fructose-induced hypertensive rats

Metabolism ◽  
2001 ◽  
Vol 50 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Dae Ho Lee ◽  
JongUn Lee ◽  
Dae Gill Kang ◽  
Yun Woong Paek ◽  
Dong Jin Chung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Hypertensive Rats ◽  
Endothelin 1 ◽  
Oxide Synthase

Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats

2001 ◽  
Vol 422 (1-3) ◽  
pp. 149-157 ◽  
Author(s):  
Naohiko Kobayashi ◽  
Yousuke Mori ◽  
Shin-ichiro Mita ◽  
Shigefumi Nakano ◽  
Tsutomu Kobayashi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hypertensive Rats ◽  
Extracellular Signal Regulated Kinase ◽  
Endothelin 1 ◽  
Extracellular Signal

Vasodilator effect of human adrenomedullin(13 – 52) on hypertensive rats

1995 ◽  
Vol 73 (7) ◽  
pp. 1065-1069 ◽  
Author(s):  
Q. Tian ◽  
D. Zhao ◽  
D. Y. Tan ◽  
Y. T. Zhao ◽  
Q. H. Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Molecular Mechanisms ◽  
Hypotensive Activity ◽  
Hypertensive Rats ◽  
Hypotensive Action ◽  
Spontaneously Hypertensive ◽  
Endothelin 1 ◽  
In Vitro Effects

Human adrenomedullin (hADM) is a newly isolated peptide with hypotensive activity in normotensive rats. The objective of this study was to investigate the effect of hADM(13–52) on hypertensive animals. hADM(13–52) induced a dose-dependent decrease in the blood pressure of spontaneously hypertensive rats and renal hypertensive rats. This result suggests that hADM is a novel antihypertensive peptide. In isolated rat aortic arteries, hADM(13–52) produced nitric oxide dependent relaxation and inhibited endothelin 1 and angiotensin II release. These in vitro effects may represent the molecular mechanisms underlying the hypotensive action of hADM in vivo.Key words: human adrenomedullin, nitric oxide, endothelin 1, angiotensin II, hypertension.

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