Effect of endurance training on fatty acid metabolism during whole body exercise

Two-thirds of all acetate to FFA conversion takes place in the hindquarter of Karakul lambs fed ad libitum. An amount equivalent to two-thirds of this net FFA production is taken up by the hind-quarter. Half ad libitum feeding resulted in halving the whole-body acteate turnover, reversing the direction of carbon flow from FFA to acetate and doubling the FFA turnover, chiefly by mobilizing tail fat. Resumption of ad libitum feeding reversed the process, without synthesizing FFA from acetate. Key words: Sheep, growth, fat-tail, FFA, acetate, turnover

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Fatty acid metabolism in the freshwater fish Murray cod (Maccullochella peelii peelii) deduced by the whole-body fatty acid balance method

Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology ◽

10.1016/j.cbpb.2006.01.013 ◽

2006 ◽

Vol 144 (1) ◽

pp. 110-118 ◽

Cited By ~ 64

Author(s):

Giovanni M. Turchini ◽

David S. Francis ◽

Sena S. De Silva

Keyword(s):

Fatty Acid ◽

Freshwater Fish ◽

Fatty Acid Metabolism ◽

Acid Metabolism ◽

Balance Method ◽

Whole Body ◽

Murray Cod

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Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [11C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism

Molecular Imaging ◽

10.1177/1536012117734485 ◽

2017 ◽

Vol 16 ◽

pp. 153601211773448 ◽

Cited By ~ 9

Author(s):

Nana L. Christensen ◽

Steen Jakobsen ◽

Anna C. Schacht ◽

Ole L. Munk ◽

Aage K. O. Alstrup ◽

...

Keyword(s):

Fatty Acid ◽

Fatty Acid Metabolism ◽

Acid Metabolism ◽

Whole Body ◽

Pet Tracer

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Effect of hyperglycemia-hyperinsulinemia on whole body and regional fatty acid metabolism

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1999.276.3.e427 ◽

1999 ◽

Vol 276 (3) ◽

pp. E427-E434 ◽

Cited By ~ 10

Author(s):

Labros S. Sidossis ◽

Bettina Mittendorfer ◽

David Chinkes ◽

Eric Walser ◽

Robert R. Wolfe

Keyword(s):

Fatty Acid ◽

Fatty Acid Oxidation ◽

Fatty Acid Metabolism ◽

Acid Metabolism ◽

Fatty Acid Uptake ◽

Whole Body ◽

Acid Oxidation ◽

Acid Uptake ◽

Similar Extent ◽

Body Level

The effects of combined hyperglycemia-hyperinsulinemia on whole body, splanchnic, and leg fatty acid metabolism were determined in five volunteers. Catheters were placed in a femoral artery and vein and a hepatic vein. U-13C-labeled fatty acids were infused, once in the basal state and, on a different occasion, during infusion of dextrose (clamp; arterial glucose 8.8 ± 0.5 mmol/l). Lipids and heparin were infused together with the dextrose to maintain plasma fatty acid concentrations at basal levels. Fatty acid availability in plasma and fatty acid uptake across the splanchnic region and the leg were similar during the basal and clamp experiments. Dextrose infusion decreased fatty acid oxidation by 51.8% (whole body), 47.4% (splanchnic), and 64.3% (leg). Similarly, the percent fatty acid uptake oxidized decreased at the whole body level (53 to 29%), across the splanchnic region (30 to 13%), and in the leg (48 to 22%) during the clamp. We conclude that, in healthy men, combined hyperglycemia-hyperinsulinemia inhibits fatty acid oxidation to a similar extent at the whole body level, across the leg, and across the splanchnic region, even when fatty acid availability is constant.

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Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00274.2004 ◽

2005 ◽

Vol 289 (1) ◽

pp. E2-E7 ◽

Cited By ~ 19

Author(s):

N. Hiscock ◽

C. P. Fischer ◽

M. Sacchetti ◽

G. van Hall ◽

M. A. Febbraio ◽

...

Keyword(s):

Fatty Acid ◽

Fatty Acid Metabolism ◽

Acid Metabolism ◽

Whole Body ◽

Constant Infusion ◽

Low Intensity ◽

Low Intensity Exercise ◽

Hormonal Milieu ◽

Exercise In Humans

The present study examined the role of the cytokine IL-6 in the regulation of fatty acid metabolism during exercise in humans. Six well-trained males completed three trials of 120 min of cycle ergometry at 70% peak O2 consumption (V̇o2 peak; MOD) and 40% V̇o2 peak with (LOW + IL-6) and without (LOW) infusion of recombinant human (rh)IL-6. The dose of rhIL-6 during LOW + IL-6 elicited IL-6 concentration similar to those during MOD but without altering the circulating hormonal milieu seen in MOD. Palmitate rate of appearance (Ra), rate of disappearance (Rd), and oxidation were measured by means of a constant infusion of [U-13C]palmitate (0.015 μmol·kg−1·min−1, prime NaHCO3, 1 μmol/kg). Palmitate Ra, Rd, and oxidation were not affected by rhIL-6 infusion, remaining similar to LOW at all times. Palmitate Ra and oxidation were significantly greater in the MOD trial ( P < 0.05) compared with the LOW + IL-6 and LOW trials. Our data show that a low dose of rhIL-6, administered during low-intensity exercise without altering the hormonal milieu, does not alter fatty acid metabolism. These data suggest that the increase in fatty acid utilization seen during exercise at moderate compared with low intensity is not mediated via alterations in plasma IL-6.

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