Abstract::
Angina pectoris, associated with coronary artery disease, a cardiovascular disease where, pain is caused by adverse
oxygen supply in myocardium, resulting in contractility and discomfort in chest. Inflammasomes, triggered by stimuli
due to infection and cellular stress have identified to play a vital role in the progression of cardiovascular disorders and thus,
causing various symptoms like angina pectoris. Nlrp3 inflammasome, a key contributor in the pathogenesis of angina pectoris,
requires activation and primary signaling for the commencement of inflammation. Nlrp3 inflammasome elicit out an
inflammatory response by emission of pro inflammatory cytokines by ROS (reactive oxygen species) production, mobilization
of K+ efflux and Ca2+ and by activation of lysosome destabilization that eventually causes pyroptosis, a programmed
cell death process. Thus, inflammasome are considered to be one of the factors involved in the progression of coronary artery
diseases and have an intricate role in development of angina pectoris.
The role of prostacyclin during exercise in patients with chronic angina pectoris.
