46. Assessment of clinical outcome in neuroendocrine tumours using functional volumes on SPET imaging and correlation with CT scan and clinical outcome

abstract We present two patients with brain abscess who underwent complete excision with a satisfactory clinical outcome although serial computerized tomography (CT) scans in the early postoperative period seemed to indicate a large residual abscess in each case. We recommend treatment based on the clinical course rather than the CT scan appearance, indicate that earlier reports on this topic may be misleading, and suggest an explanation for these findings.

Download Full-text

Radiological Parameters Predicting Clinical Outcome After Decompressive Hemicraniectomy in Malignant Ischemic Stroke

Neurosurgery ◽

10.1093/neuros/nyz310_840 ◽

2019 ◽

Vol 66 (Supplement_1) ◽

Author(s):

Nida Fatima

Keyword(s):

Ischemic Stroke ◽

Clinical Outcome ◽

Ct Scan ◽

Functional Outcome ◽

Hemorrhagic Transformation ◽

Decompressive Hemicraniectomy ◽

Radiological Parameters ◽

Good Functional Outcome ◽

The Mean ◽

Basal Cisterns

Abstract INTRODUCTION Decompressive Hemicraniectomy (DH) is advocated as a lifesaving procedure in the management of patients with raised intracranial pressure due to malignant hemispheric infarction. The purpose of this study was to identify radiological parameters predicting the clinical outcome in patients with DH in large-territory ischemic stroke. METHODS Patients undergoing DH for malignant ischemic stroke were identified from electronic data base search (2011-2018). Logistic regression analysis evaluated the association of radiological variables with clinical outcome according to modified Rankin Scale (mRS) and Glasgow Outcome Scale Extended (GOSE) at 180 d. RESULTS Among 98 patients, 59 (60.2%) underwent CT scan post DH within 24 h. The median age of the included patients was 54 yr (29-80 yr), with males being predominant (89.8%). The mean NIHSS score for the included patients was 18.64 ± 6.8 (3-33), and majority of the patients (88.1%) had Middle Cerebral Artery Infarction (MCA). The mean mRS and GOSE at 180 d were 3.88 ± 1.39 and 4.12 ± 1.8, respectively. Univariate analysis identified a greater likelihood of good functional outcome in patients with ischemic stroke post DH on CT scan if there was absence of effacement of cortical sulci [OR 1.31: 95% CI: 1.28-1.39; P = .05], absence of effacement of basal cisterns [OR 3.4: 95% CI:1.36-8.5; P = .03], absence of hemorrhagic transformation in the infarct core [OR 2.3: 95% CI: 2.00-2.65; P = .03], or absence of compression of lateral ventricle [OR 1.25: 95% CI: 1.20-1.27; P = .05]. Furthermore, multivariate analysis found significant association in predicting good functional outcome with absence of effacement of cortical sulci [OR 2.01: 95% CI: 1.22-20.71; P = .02], absence of hemorrhagic transformation [OR 2.09: 95% CI: 1.01-27.30; P = .02], and absence of compression of lateral ventricles [OR 1.35: 95% CI: 1.28-18.4; P = .05], but absence of effacement of basal cisterns was not statistically significant (P = .36). CONCLUSION The radiographic features post DH in ischemic stroke predict the clinical outcome, thus stratify our management plan.

Download Full-text

Flow and image cytometric study of pancreatic neuroendocrine tumours: Frequent DNA aneuploidy and an association with the clinical outcome

Virchows Archiv A Pathological Anatomy and Histopathology ◽

10.1007/bf01607044 ◽

1992 ◽

Vol 421 (2) ◽

pp. 121-125 ◽

Cited By ~ 6

Author(s):

Kalle A. Alanen ◽

Ursula G. Falkmer ◽

Pekka J. Klemi ◽

Heikki Joensuu ◽

Sture Falkmer

Keyword(s):

Clinical Outcome ◽

Neuroendocrine Tumours ◽

Dna Aneuploidy ◽

Pancreatic Neuroendocrine Tumours

Download Full-text

Co-existence of cerebral cysticercosis with Japanese encephalitis: a prognostic modulator

Epidemiology and Infection ◽

10.1017/s0950268896007327 ◽

1997 ◽

Vol 118 (2) ◽

pp. 165-171 ◽

Cited By ~ 31

Author(s):

A. DESAI ◽

S. K. SHANKAR ◽

P. N. JAYAKUMAR ◽

A. CHANDRAMUKI ◽

M. GOURIE-DEVI ◽

...

Keyword(s):

Clinical Outcome ◽

Ct Scan ◽

Japanese Encephalitis ◽

Antibody Detection ◽

Poor Outcome ◽

Cysticercus Cellulosae ◽

Cerebral Cysticercosis ◽

Antibody Levels ◽

The Brain

In this study, we investigated the frequency of co-existence of cerebral cysticercosis (CC) in Japanese encephalitis (JE) cases with special emphasis on its role in predicting the final clinical outcome. Amongst the 163 confirmed cases of JE, 37·42% (61/163) had co-existent CC. This was confirmed by antibody detection in the CSF of 45 cases, CT scan of the brain in 6 cases and at autopsy in 3 cases. In 2 cases confirmation was possible by CT scan as well as at autopsy, in 4, CSF antibody levels and CT scan were suggestive of CC while in 1, CSF antibodies and autopsy were suggestive of CC. The co-occurrence of Cysticercus cellulosae in the brain emerged as a prognosticator of poor outcome in JE cases (P<0·03).

Download Full-text

Good clinical outcome in a patient with a large CT scan hypodensity treated with intra-arterial urokinase after an embolic stroke

Neurology ◽

10.1212/wnl.47.4.1076 ◽

1996 ◽

Vol 47 (4) ◽

pp. 1076-1078 ◽

Cited By ~ 13

Author(s):

R. Tarr ◽

C. L. Taylor ◽

W. R. Selman ◽

J. S. Lewin ◽

D. Landis

Keyword(s):

Clinical Outcome ◽

Ct Scan ◽

Embolic Stroke ◽

Good Clinical Outcome

Download Full-text

Prediction of clinical outcome in acute hemorrhagic stroke from a single CT scan on admission

North American Journal of Medical Sciences ◽

10.4103/1947-2714.101986 ◽

2012 ◽

Vol 4 (10) ◽

pp. 463 ◽

Cited By ~ 11

Author(s):

Chiranjib Nag ◽

Mrinalkanti Ghosh ◽

MR Khandakar ◽

Kamalesh Das

Keyword(s):

Clinical Outcome ◽

Ct Scan ◽

Hemorrhagic Stroke ◽

Acute Hemorrhagic Stroke

Download Full-text

Optic nerve sheath diameter sonography during the acute stage of intracerebral hemorrhage: a potential role in monitoring neurocritical patients

The Ultrasound Journal ◽

10.1186/s13089-020-00196-1 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

M. Bender ◽

S. Lakicevic ◽

N. Pravdic ◽

S. Schreiber ◽

B. Malojcic

Keyword(s):

Optic Nerve ◽

Clinical Outcome ◽

Intracerebral Hemorrhage ◽

Ct Scan ◽

Healthy Volunteers ◽

Optic Nerve Sheath Diameter ◽

Acute Stage ◽

Optic Nerve Sheath ◽

Nerve Sheath ◽

Brain Ct Scan

Abstract Background Optic nerve sheath diameter (ONSD) sonography has been proposed as a reliable bedside tool for the detection of increased intracranial pressure (ICP). ONSD reacts almost simultaneously to oscillations in ICP. The aim of this study was to investigate the ONSD dynamics in the acute stage of intracerebral hemorrhage (ICH) and to compare ONSD dynamics to the clinical outcome. Methods We enrolled 35 acute ICH patients and 20 healthy volunteers in this prospective study. At the admission, all patients underwent brain CT scan and ONSD sonography. We repeated the ONSD on the second and the third day in all patients while CT scan was repeated if a patient condition deteriorated. The changes in serial ONSD measurements were termed as stable or unstable ONSD trend. ONSD trend was considered as unstable if variations of average ONSD were above 5%. The outcome of the patient was assessed with the Modified Rankin Scale (mRS) and Glasgow Outcome Scale (GOS). Results In healthy volunteers serial ONSD recordings for 3 days revealed a stable trend in 100%. However, in the study group, 23 patients had unstable and 12 had stable ONSD trend during the acute stage of ICH. The patients with unstable ONSD trend were more likely to have worse outcomes (p value 0.003). Conclusion In patients with ICH, the acute-phase ONSD dynamics can help in predicting the clinical outcome.

Download Full-text