A Longitudinal Study of Maternal Dose Response to Low Molecular Weight Heparin in Pregnancy

2003 ◽  
Vol 101 (6) ◽  
pp. 1307-1311 ◽  
Author(s):  
V. Sephton ◽  
R. G. Farquharson ◽  
J. Topping ◽  
S. M. Quenby ◽  
C. Cowan ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Longitudinal Study ◽  
Dose Response ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
In Pregnancy

Thrombosis and embolism in pregnancy

2020 ◽  
pp. 206-212
Author(s):  
Ian A. Greer
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Objective Assessment ◽  
Fold Increase ◽  
Low Molecular Weight ◽  
Thoracic Imaging ◽  
Mortality And Morbidity ◽  
First Choice ◽  
Daily Risk ◽  
In Pregnancy

Venous thromboembolism (VTE) is a leading cause of maternal mortality and morbidity. Prophylaxis and management of VTE in pregnancy can impact mortality and morbidity. The overall reported incidence of gestational VTE ranges from 0.5 to 2.2 per 1000 maternities with a relative 5–10-fold increase in risk during pregnancy, increasing to a daily risk of 15–35-fold in the puerperium, compared with non-pregnant women of similar age. Risk factors inform the use of thromboprophylaxis usually with low-molecular-weight heparin, which has a better safety profile than unfractionated heparin. VTE can occur at any time in pregnancy, but over 50% of events occur prior to 20 weeks’ gestation. As clinical diagnosis is unreliable, objective assessment is required when there is clinical suspicion of an event. Less than 10% of clinically suspected cases of VTE are confirmed on objective testing. Compression duplex ultrasonography is the first-line investigation for suspected gestational deep venous thrombosis and thoracic imaging with ventilation–perfusion scanning is required for suspected pulmonary embolism. Low-molecular-weight heparin is usually the first choice treatment for gestational VTE based on safety and efficacy.

Preeclampsia prevention strategies. Pharmacokinetics and pharmacodynamics of low-molecular-weight heparin (LMWH) in pregnancy

2020 ◽  
Vol 2 (28) ◽  
pp. 18
Author(s):  
Natalia Turcan ◽  
Roxana Bohâlțea ◽  
Ducu Ioniţă ◽  
Alexandru Baroş ◽  
Eugen Radu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Prevention Strategies ◽  
Pharmacokinetics And Pharmacodynamics ◽  
In Pregnancy
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