Age at first birth, parity, and breast cancer risk

1983 ◽  
Vol 72 (4) ◽  
pp. 582
Author(s):  
Hal G. Bingham
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Age At First Birth ◽  
First Birth ◽  
Birth Parity

Identification of factors associated with high breast cancer risk in the mothers of children with soft tissue sarcoma.

1990 ◽  
Vol 8 (4) ◽  
pp. 583-590 ◽  
Author(s):  
J M Birch ◽  
A L Hartley ◽  
V Blair ◽  
A M Kelsey ◽  
M Harris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Soft Tissue ◽  
Breast Cancer Risk ◽  
Soft Tissue Sarcoma ◽  
Cancer Risk ◽  
Cancer Genetics ◽  
Age At First Birth ◽  
Index Child ◽  
High Breast Cancer Risk ◽  
Age At Birth

Information on the past medical history of the mothers of a population-based series of 177 children with soft tissue sarcoma was obtained by interview and from medical records. Eight mothers developed breast cancer, six premenopausally, compared with 3.26 expected (P = .04), but no excess of other types of cancers was detected. High breast cancer risk was associated with the following factors in the index child: age at diagnosis less than 24 months (relative risk [RR], 7.84), embryonal rhabdomyosarcoma (RR, 3.74), and male sex (RR, 3.02). Characteristics in the mother associated with high breast cancer risk were the following: late age at first birth (RR, 5.13), late age at birth of index child (RR, 5.69), and high birth-rank order of index child (RR, 4.08). The results suggest there may be a subset of childhood soft tissue sarcoma with a predominantly genetic etiology. The association between premenopausal breast cancer in the mother, late age at birth of index child, and early onset of soft tissue sarcoma in the index child suggests that these three events are not independent and that interactions between genetic and other factors may be important. The identification of a group of women at high risk for breast cancer affords an opportunity for screening and early detection. The study of cancer family syndromes may provide insights into underlying mechanisms in cancer genetics.

Age at first birth, parity and risk of breast cancer: A meta-analysis of 8 studies from the nordic countries

1990 ◽  
Vol 46 (4) ◽  
pp. 597-603 ◽  
Author(s):  
Marianne Ewertz ◽  
Stephen W. Duffy ◽  
Hans-Olov Adami ◽  
Gunnar Kvåle ◽  
Eiliv Lund ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Meta Analysis ◽  
Nordic Countries ◽  
Age At First Birth ◽  
First Birth ◽  
Birth Parity

scholarly journals Age at first birth, parity and risk of breast cancer in a Swedish population

1980 ◽  
Vol 42 (5) ◽  
pp. 651-658 ◽  
Author(s):  
H O Adami ◽  
J Hansen ◽  
B Jung ◽  
Å J Rimsten
Keyword(s):  
Breast Cancer ◽  
Age At First Birth ◽  
First Birth ◽  
Swedish Population ◽  
Birth Parity

scholarly journals Associations of reproductive breast cancer risk factors with breast tissue composition

2020 ◽  
Author(s):  
Lusine Yaghjyan ◽  
Rebecca Jane Austin-Datta ◽  
Hannah Oh ◽  
Yujing J Heng ◽  
Adithya D Vellal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Reproductive Factors ◽  
Tissue Type ◽  
Health Study ◽  
Age At First Birth ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors

Abstract Background We investigated the associations of reproductive factors with percentage of epithelium, stroma, and fat tissue in benign breast biopsy samples. Methods This study included 983 cancer-free women with biopsy-confirmed benign breast disease (BBD) within the Nurses’ Health Study and Nurses’ Health Study II cohorts. Percentage of each tissue type (epithelium stroma, and fat) was measured on whole section images with a deep-learning technique. All tissue measures were log-transformed in all the analyses to improve normality. The data on reproductive variables and other breast cancer risk factors were obtained from biennial questionnaires. Generalized linear regression was used to examine the associations of reproductive factors with percentage of tissue types, while adjusting for known breast cancer risk factors. Results As compared to parous women, nulliparous women had a smaller percentage of epithelium (β= -0.26, 95% confidence interval [CI] -0.41, -0.11) and fat (β= -0.34, 95% CI -0.54, -0.13) and a greater percentage of stroma (β = 0.04, 95% CI 0.01, 0.08). Among parous women, number of children was inversely associated with percentage of stroma (β per child= -0.01 (-0.02, -0.00). Duration of breastfeeding of ≥ 24 months was associated with a reduced proportion of fat (β= -0.30, 95% CI -0.54, -0.06; p-trend = 0.04). In a separate analysis restricted to premenopausal women, older age at first birth was associated with a greater proportion of epithelium and a smaller proportion of stroma. Conclusions Our findings suggest that reproductive factors with a protective effect on breast cancer risk may be associated with a greater proportion of epithelium and a smaller proportion of stroma, potentially suggesting importance of epithelial-stromal interactions. Future studies are warranted to confirm our findings and to elucidate the underlying biological mechanisms.

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