The Role of the Glucocorticoid-Dependent Mechanism in the Progression of Sodium Taurocholate–Induced Acute Pancreatitis in the Rat

The role of liver in the respiratory dysfunction associated with acute pancreatitis has been evaluated. For this purpose, an experimental necrohemorrhagic pancreatitis was induced in rats by intraductal administration of 3.5% sodium taurocholate. Additionally, a portocaval shunt was performed before induction of acute pancreatitis to prevent the initial passage through the liver of substances released by the pancreas. Twelve hours after the induction of pancreatitis, increases in lung prostacyclin and thromboxane B2 synthesis, decreased lung superoxide dismutase activity, and increases in plasma phospholipase A2 activity were found. In addition, inflammatory injury was evidenced in lung by histopathological analysis. The portocaval shunt was able to prevent the metabolic changes and ameliorate the inflammatory process in the lung, suggesting that the liver plays an active role in the systemic inflammatory response to acute pancreatitis.

Download Full-text

W1826 The Effect of Rosiglitasone, a Specific PPAR -Gamma Ligand, On the Development of Experimental Sodium Taurocholate Induced Acute Pancreatitis and the Role of Immunohistochemical Reaction

Gastroenterology ◽

10.1016/s0016-5085(08)63380-6 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-723

Author(s):

Krzysztof Celinski ◽

Beata Prozorow-Krol ◽

Agnieszka Korolczuk ◽

Grazyna Czechowska ◽

Maria Slomka ◽

...

Keyword(s):

Acute Pancreatitis ◽

Sodium Taurocholate ◽

Ppar Gamma ◽

Immunohistochemical Reaction

Download Full-text

Changes in noradrenaline and dopamine levels under oxygen debt conditions in the brain of rats during experimental acute pancreatitis

Medycyna Weterynaryjna ◽

10.21521/mw.6591 ◽

2022 ◽

Vol 77 (11) ◽

pp. 6589-2022

Author(s):

AGNIESZKA MARKIEWICZ-GOSPODAREK ◽

IWONA ŁUSZCZEWSKA-SIERAKOWSKA ◽

PIOTR KUSZTA ◽

MARCIN KOPIENIAK ◽

ELŻBIETA RADZIKOWSKA-BÜCHNER

Keyword(s):

Acute Pancreatitis ◽

Sodium Taurocholate ◽

Mechanical Damage ◽

Oxygen Debt ◽

Research Groups ◽

Emotional Processes ◽

The Common ◽

The Brain

This study’s aim was to assess the level of catecholamines, i.e., noradrenaline and dopamine, under oxygen debt conditions in the brain of experimental animals in which acute pancreatitis was experimentally induced. Catecholamines play the role of neurotransmitters and neuromediators. They are responsible for the regulation of motor and emotional processes, take part in the regulation of hormonal activities, sleep, wakefulness, concentration, attention, and learning processes. The experiment also determined the oxygen tension as an indicator of respiratory failure and the activity of amylase and lipase in the development of the inflammatory process. The animals on which the experiment was conducted were Wistar rats (140 animals) divided into 3 research groups: control (C) animals (n = 30), healthy (H) animals (n = 30), and operated (O) animals (n = 80). The determination of amylase, lipase, oxygen pressure, NA, and DO levels were performed at hours 2, 6, 12, 24, and 48 of the experiment. The animals in group C had an injection needle inserted to investigate only the effects of mechanical damage to the organs. On the other hand, the animals in group O had a 5% solution of sodium taurocholate introduced into the common bile-pancreatic duct. The research conducted shows that the most significant changes in NA and DO levels were observed on the first day of the experiment. The concentrations of the above catecholamines were statistically significantly correlated with the level of amylase in the blood. The peak of dopamine was observed between the 6th and 12th hours of the experiment, while the lowest concentration of noradrenaline was observed at the 6th hour of the experiment.

Download Full-text