Role of Pancreatic Stone Protein as an Early Biomarker for Risk Stratification of Acute Pancreatitis

2021 ◽  
Author(s):  
Carlos Rodríguez Rojas ◽  
Luis García de Guadiana-Romualdo ◽  
Senador Morán Sánchez ◽  
Josef Prazak ◽  
Virginia Algara Soriano ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Risk Stratification ◽  
Pancreatic Stone Protein ◽  
Pancreatic Stone ◽  
Early Biomarker

scholarly journals Early Risk Stratification in Acute Pancreatitis: The Role of Biochemical and Hematological Parameters

2020 ◽  
Vol 17 (3) ◽  
pp. 11-18
Author(s):  
Georgiana Cătălina Crișu ◽  
Vasile Daniel Balaban ◽  
Laura Elena Gaman ◽  
Mariana Jinga ◽  
Flavius Stefan Marin ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Acute Pancreatitis ◽  
Risk Stratification ◽  
Hospital Stay ◽  
Hematological Parameters ◽  
Length Of Hospital Stay ◽  
Systemic Complications ◽  
Early Risk ◽  
Length Of Hospitalization

AbstractAcute pancreatitis (AP) represents an inflammatory condition,-with a wide spectrum of local and systemic complications. Early stratification of severity of pancreatitis is an important step in guiding the management of the disease and improving outcomes. Throughout the years many researchers have looked at various risk stratification parameters which could be used from the admission of patients, however current available scores are cumbersome.Our aim was to evaluate the role of biochemical and hematological parameters in the early stratification of severity of AP, regarding the length of hospitalization.We conducted an observational study which included 100 patients with AP admitted to the Gastroenterology Department over a period 18 months. AP diagnosis was set according to 2013 ACG criteria. Demographic, clinical and imaging data related to the pancreatitis flare were collected from their charts. Length of hospital stay was used as surrogate marker for severity of AP. We evaluated different biochemical and hematological parameters which influenced the length of hospitalization.Several hematological parameters and ratio did not correlate with length of hospital stay in our study cohort, however there was a significant relation of hyperglycemia and alkaline phosphatase levels with hospitalization duration.Early risk stratification in AP remains difficult with routine blood work done at admission. Glycemic control and serum level of alkaline phosphatase seems to be correlated with length of hospital stay.

scholarly journals The Role of Pancreatic Stone Protein in Diagnosis of Early Onset Neonatal Sepsis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Anwar A. Rass ◽  
Mohamed A. Talat ◽  
Mohamed A. Arafa ◽  
Hosam F. El-Saadany ◽  
Ezzat K. Amin ◽  
...  
Keyword(s):  
Negative Predictive Value ◽  
Neonatal Sepsis ◽  
Predictive Value ◽  
Early Onset ◽  
Infected Group ◽  
Pancreatic Stone Protein ◽  
University Hospitals ◽  
Suspected Sepsis ◽  
Pancreatic Stone

Introduction. Early diagnosis and treatment of neonatal sepsis may help decrease neonatal mortality.Aim of the Study. To evaluate the role of pancreatic stone protein as a marker for early onset neonatal sepsis.Methods. A hospital-based prospective study was conducted on 104 (52 uninfected and 52 infected neonates) admitted to the Neonatal Intensive Care Unit (NICU) of Zagazig University hospitals during the period from April 2014 to April 2015. All newborns were subjected to full history taking, careful neonatal assessment, blood, C-reactive protein (CRP), and serum pancreatic stone protein.Results. Serum PSP levels were significantly higher in the infected group than in the uninfected group. At a cutoff level of PSP 12.96 ng/mL, the sensitivity was 96.2%, the specificity was 88.5%, positive predictive value was 95.8%, negative predictive value was 89.3%, and area under the curve was 0.87. A significant positive correlation between CRP and PSP was found in infected group.Conclusion. The high negative predictive value of PSP (89.3%) indicates that the serum PSP level is a good marker for diagnosis of early onset neonatal sepsis and can be used to limit hospital stay and antibiotic use in neonates treated for suspected sepsis.

Molecular Forms of Serum Pancreatic Stone Protein in Acute Pancreatitis

1999 ◽  
Vol 25 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Yasuyuki Nakae ◽  
Satoru Naruse ◽  
Motoji Kitagawa ◽  
Hiroshi Ishiguro ◽  
Masanori Kato ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Molecular Forms ◽  
Pancreatic Stone Protein ◽  
Pancreatic Stone

scholarly journals Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management

Critical Care ◽  
2012 ◽  
Vol 16 (4) ◽  
pp. R114 ◽  
Author(s):  
Yok-Ai Que ◽  
Frederik Delodder ◽  
Idris Guessous ◽  
Rolf Graf ◽  
Martha Bain ◽  
...  
Keyword(s):  
Prospective Cohort ◽  
Pancreatic Stone Protein ◽  
Pancreatic Stone ◽  
Early Biomarker ◽  
Icu Management

scholarly journals Circulating Blood miR-155 and miR-21 Promote the Development of Acute Pancreatitis and Can Be Used to Assess the Risk Stratification of Pancreatitis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Lan Hu ◽  
Dongdong Han ◽  
Diao Yu ◽  
Dongji Ao ◽  
Zhengyi Yang
Keyword(s):  
Risk Factors ◽  
Acute Pancreatitis ◽  
Risk Stratification ◽  
Roc Analysis ◽  
Gastrointestinal Hormones ◽  
Control Group ◽  
Detection Level ◽  
Diagnostic Efficacy ◽  
Critical Patients

To explore the role of circulating blood miR-155 and miR-21 in promoting acute pancreatitis (AP) and evaluating the risk stratification of pancreatitis. In this experiment, 70 patients with AP treated in our hospital from October 2019 to December 2020 were included in the research group (RG), and the blood of 52 healthy cases was collected and they were included in the control group (CG). The expression of miR-155 and miR-21 in circulating blood was observed in the two groups. The diagnostic efficacy of miR-155 and miR-21 in AP was observed. The risk factors of patients with AP were observed. The expression of serum gastrointestinal hormones was observed in the two groups. The GAS and VIP in RG were higher than those in CG, while MTL and CCK were lower than those in CG. Moreover, the detection level of mild, moderate, severe, and critical patients was also significantly different ( P < 0.05 ). The expression of miR-155 and miR-21 in circulating blood of RG was significantly lower than that of CG ( P < 0.05 ), and the area under the miR-155 curve was 0.775 and the area under the miR-21 curve was 0.832. Alcoholism, GAS, VIP, MTL, CCK, miR-155, and miR-21 were the risk factors of patients. miR-155 and miR-21 show low expression in the serum of patients. The lower the expression, the more serious the disease. They are closely related to the development of AP. miR-155 and miR-21 have good diagnostic efficacy by ROC analysis, and they are expected to become effective indicators for the diagnosis and treatment of AP in the future.

Galectin-3 in Heart Failure – Linking Fibrosis, Remodelling and Progression

2010 ◽  
Vol 6 (2) ◽  
pp. 33 ◽  
Author(s):  
Christopher R deFilippi ◽  
G Michael Felker ◽  
◽  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Risk Stratification ◽  
Cardiac Fibrosis ◽  
The Elderly ◽  
Preserved Ejection Fraction ◽  
Heart Failure Patients ◽  
Large Populations ◽  
Galectin 3

For many with heart failure, including the elderly and those with a preserved ejection fraction, both risk stratification and treatment are challenging. For these large populations and others there is increasing recognition of the role of cardiac fibrosis in the pathophysiology of heart failure. Galectin-3 is a novel biomarker of fibrosis and cardiac remodelling that represents an intriguing link between inflammation and fibrosis. In this article we review the biology of galectin-3, recent clinical research and its application in the management of heart failure patients.

Bridging the Knowledge Gaps in Arrhythmogenic Cardiovascular Conditions: The Critical Role of Registries

2016 ◽  
Vol 10 (2) ◽  
pp. 1 ◽  
Author(s):  
Melody Hermel ◽  
Rebecca Duffy ◽  
Alexander Orfanos ◽  
Isabelle Hack ◽  
Shayna McEnteggart ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Natural History ◽  
Risk Stratification ◽  
Critical Role ◽  
Knowledge Gaps ◽  
Level Of Evidence ◽  
The Future

Cardiac registries have filled many gaps in knowledge related to arrhythmogenic cardiovascular conditions. Despite the less robust level of evidence available in registries when compared with clinical trials, registries have contributed a range of clinically useful information. In this review, the authors discuss the role that registries have played – related to diagnosis, natural history, risk stratification, treatment, and genetics of arrhythmogenic cardiovascular conditions – in closing knowledge gaps, and their role in the future.

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