EFFECT OF SUBTHRESHOLD INFRARED LASER TREATMENT FOR DRUSEN REGRESSION ON MACULAR AUTOFLUORESCENCE IN PATIENTS WITH AGE-RELATED MACULAR DEGENERATION

Retina ◽  
2005 ◽  
Vol 25 (8) ◽  
pp. 981-988 ◽  
Author(s):  
KENICHIRO BESSHO ◽  
NUTTAWUT RODANANT ◽  
DIRK-UWE G. BARTSCH ◽  
LINGYUN CHENG ◽  
HYOUNG-JUN KOH ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Laser Treatment ◽  
Infrared Laser ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Giuseppe Querques ◽  
Riccardo Sacconi ◽  
Francesco Gelormini ◽  
Enrico Borrelli ◽  
Francesco Prascina ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Laser Treatment ◽  
Age Related Macular Degeneration ◽  
Short Term ◽  
Treated Area ◽  
Reticular Pseudodrusen ◽  
End Point ◽  
Age Related ◽  
Subthreshold Laser

AbstractThere is a lack of treatment aimed at the regression of reticular pseudodrusen (RPD) secondary to age-related macular degeneration (AMD). The aim of this prospective, pilot study is to evaluate the safety and short-term efficacy of subthreshold laser treatment (SLT) in patients affected by RPD secondary to dry AMD (dAMD). Twenty eyes of 20 patients (mean age 78.4 ± 6.8 years) with RPD secondary to dAMD were prospectively enrolled. All patients were treated in an extrafoveal area of 1.27 mm2 using end-point management yellow subthreshold laser and followed for 3 months. Best-corrected visual acuity was 0.140 ± 0.09 LogMAR at the baseline and no changes were observed during the follow-up (p = 0.232). No significant worsening was disclosed before and after the treatment analyzing the macular sensitivity of the treated area (p = 0.152). No topical and/or systemic side effects were disclosed during the 3-month follow-up. The distribution among the RPD stages changed after the treatment (p < 0.001). In detail, in the treated area, we observed a significant increase in the number of Stage 1 RPD during the follow-up (p = 0.002), associated with a significant decrease of Stage 3 RPD (p = 0.020). Outer nuclear layer (ONL) thickness analysis showed a significant increase after the treatment associated with RPD regression (p = 0.001). End-point management SLT appears a safe treatment for RPD secondary to dAMD, showing short-term safety outcomes. Our results suggest that SLT could be effective in inducing a RPD regression in terms of RPD stage and ONL thickening.

scholarly journals Subthreshold Nano-Second Laser Treatment and Age-Related Macular Degeneration

2021 ◽  
Vol 10 (3) ◽  
pp. 484
Author(s):  
Amy C. Cohn ◽  
Zhichao Wu ◽  
Andrew I. Jobling ◽  
Erica L. Fletcher ◽  
Robyn H. Guymer
Keyword(s):  
Macular Degeneration ◽  
Laser Treatment ◽  
Short Pulse ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Nanosecond Laser ◽  
Age Related ◽  
Short Pulse Lasers

The presence of drusen is an important hallmark of age-related macular degeneration (AMD). Laser-induced regression of drusen, first observed over four decades ago, has led to much interest in the potential role of lasers in slowing the progression of the disease. In this article, we summarise the key insights from pre-clinical studies into the possible mechanisms of action of various laser interventions that result in beneficial changes in the retinal pigment epithelium/Bruch’s membrane/choriocapillaris interface. Key learnings from clinical trials of laser treatment in AMD are also summarised, concentrating on the evolution of laser technology towards short pulse, non-thermal delivery such as the nanosecond laser. The evolution in our understanding of AMD, through advances in multimodal imaging and functional testing, as well as ongoing investigation of key pathological mechanisms, have all helped to set the scene for further well-conducted randomised trials to further explore potential utility of the nanosecond and other subthreshold short pulse lasers in AMD.

scholarly journals The efficiency of surgical and laser treatment of the age-related macular degeneration wet form

2011 ◽  
Vol 10 (4) ◽  
pp. 166-170
Author(s):  
Yu. I. Khoroshikh ◽  
O. I. Krivosheina ◽  
I. V. Zapuskalov
Keyword(s):  
Comparative Analysis ◽  
Medical Treatment ◽  
Macular Degeneration ◽  
Laser Treatment ◽  
Functional Results ◽  
Age Related Macular Degeneration ◽  
Laser Coagulation ◽  
Clinical Form ◽  
Age Related

The results of comparative analysis of the efficiency between different sorts of the age-related macular degeneration treatment wet form has been presented in the article. There was demonstrated that choosing the treatment tactics in such pathology patients used to consider the clinical form and the stage of the disease. The wet form needs pneumoretinopexy with following of retina laser coagulation. The subretinal fibrovascular membrane is indications for transcilliary vitrectomy with removal of proliferate tissue. The traditional medical treatment of wet form of age-related macular degeneration does not ensure stable clinical and functional results.

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