PEPTIDES DERIVED FROM α-HELICES OF ALLOGENEIC CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ARE POTENT INDUCERS OF CD4+ AND CD8+ T CELL AND B CELL RESPONSES AFTER CARDIAC ALLOGRAFT REJECTION

1995 ◽  
Vol 59 (3) ◽  
pp. 401-409 ◽  
Author(s):  
HAVAL SHIRWAN ◽  
MICHAELA LEAMER ◽  
HONG K. WANG ◽  
LEONARD MAKOWKA ◽  
DONALD V. CRAMER
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
B Cell ◽  
Allograft Rejection ◽  
Cd8 T Cell ◽  
Cardiac Allograft ◽  
Cardiac Allograft Rejection ◽  
Cell Responses ◽  
Major Histocompatibility Complex Antigens ◽  
Histocompatibility Complex

scholarly journals Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Science ◽  
2016 ◽  
Vol 351 (6274) ◽  
pp. 714-720 ◽  
Author(s):  
S. G. Hansen ◽  
H. L. Wu ◽  
B. J. Burwitz ◽  
C. M. Hughes ◽  
K. B. Hammond ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Major Histocompatibility ◽  
Cell Responses ◽  
Histocompatibility Complex

scholarly journals CD8+ T cell response to Mls-1a determinants involves major histocompatibility complex class II molecules.

1991 ◽  
Vol 173 (3) ◽  
pp. 779-782 ◽  
Author(s):  
Y Chvatchko ◽  
H R MacDonald
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
Mhc Class Ii ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Class Ii ◽  
T Cell Response ◽  
Major Histocompatibility ◽  
Cell Responses ◽  
Histocompatibility Complex

Recent studies indicate that both CD4+ and CD8+ T lymphocytes proliferate in vitro in response to Mls-1a-encoded determinants. Using both immunogenetic and antibody blocking approaches we show here that Mls-1a responses of both subsets require expression of major histocompatibility complex (MHC) class II molecules (I-A and/or I-E) by the stimulator cells. Furthermore, CD8+ T cell responses to Mls-1a/class II MHC do not require (and are in fact inhibited by) the presence of functional CD8 molecules. Taken together, our data underscore the dramatic differences between CD8+ T cell responses to conventional peptide antigens as opposed to "superantigens" such as Mls-1a.

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