Mitomycin-C Treatment Alters Acute Phase Response Signaling of Pancreatic Islets: Comprehensive Analysis of Islet Gene Expression.

2014 ◽  
Vol 98 ◽  
pp. 363
Author(s):  
N. Sato ◽  
T. Anazawa ◽  
J. Haga ◽  
A. Kenjo ◽  
T. Kimura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Islets ◽  
Mitomycin C ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Comprehensive Analysis ◽  
Phase Response

scholarly journals ECM Characterization Reveals a Massive Activation of Acute Phase Response during FSGS

2020 ◽  
Vol 21 (6) ◽  
pp. 2095 ◽  
Author(s):  
Eva Nora Bukosza ◽  
Christoph Kornauth ◽  
Karin Hummel ◽  
Helga Schachner ◽  
Nicole Huttary ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Wilms Tumor ◽  
Comprehensive Analysis ◽  
Phase Response ◽  
Expression Data ◽  
Functional Interaction ◽  
Novel Targets ◽  
Proteome Changes ◽  
Complementary Analysis

The glomerular basement membrane (GBM) and extra-cellular matrix (ECM) are essential to maintain a functional interaction between the glomerular podocytes and the fenestrated endothelial cells in the formation of the slit diaphragm for the filtration of blood. Dysregulation of ECM homeostasis can cause Focal segmental glomerulosclerosis (FSGS). Despite this central role, alterations in ECM composition during FSGS have not been analyzed in detail yet. Here, we characterized the ECM proteome changes in miR-193a-overexpressing mice, which suffer from FSGS due to suppression of Wilms’ tumor 1 (WT1). By mass spectrometry we identified a massive activation of the acute phase response, especially the complement and fibrinogen pathways. Several protease inhibitors (ITIH1, SERPINA1, SERPINA3) were also strongly increased. Complementary analysis of RNA expression data from both miR-193a mice and human FSGS patients identified additional candidate genes also mainly involved in the acute phase response. In total, we identified more than 60 dysregulated, ECM-associated genes with potential relevance for FSGS progression. Our comprehensive analysis of a murine FSGS model and translational comparison with human data offers novel targets for FSGS therapy.

scholarly journals STAT3/NFκB Interplay in the Regulation of α2-Macroglobulin Gene Expression During Rat Liver Development and the Acute Phase Response

IUBMB Life ◽  
2007 ◽  
Vol 59 (3) ◽  
pp. 170-178 ◽  
Author(s):  
Aleksandra Uskokovic ◽  
Svetlana Dinic ◽  
Mirjana Mihailovic ◽  
Ilijana Grigorov ◽  
Svetlana Ivanovic-Matic ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Liver Development ◽  
Α2 Macroglobulin

scholarly journals Ah receptor represses acute-phase response gene expression without binding to its cognate response element

2009 ◽  
Vol 89 (6) ◽  
pp. 695-707 ◽  
Author(s):  
Rushang D Patel ◽  
Iain A Murray ◽  
Colin A Flaveny ◽  
Ann Kusnadi ◽  
Gary H Perdew
Keyword(s):  
Gene Expression ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Ah Receptor ◽  
Response Gene ◽  
Response Element

Lipocalin-2 gene expression and production in a model of acute phase response reaction

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
M Pascucci ◽  
A Bianchi ◽  
P Ramadori ◽  
S Sultan ◽  
G Martius
Keyword(s):  
Gene Expression ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Lipocalin 2

scholarly journals Gene Expression Analysis of the Acute Phase Response Using a Canine Microarray

2003 ◽  
Vol 74 (2) ◽  
pp. 470-484 ◽  
Author(s):  
M. A. Higgins ◽  
B. R. Berridge ◽  
B. J. Mills ◽  
A. E. Schultze ◽  
H. Gao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Phase ◽  
Expression Analysis ◽  
Acute Phase Response ◽  
Gene Expression Analysis ◽  
Phase Response
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