Donation After Circulatory Death (DCD) Renal Allografts: The Impact of Donor Age On Recipient Outcome in a Contemporary Canadian Cohort.

2014 ◽  
Vol 98 ◽  
pp. 595
Author(s):  
N. Rowe ◽  
M. Huynh ◽  
P. Violette ◽  
C. Weernink ◽  
A. Sener ◽  
...  
Keyword(s):  
Donation After Circulatory Death ◽  
Donor Age ◽  
Renal Allografts ◽  
The Impact ◽  
Circulatory Death

PD30-10 DONATION AFTER CIRCULATORY DEATH (DCD) RENAL ALLOGRAFTS: RECIPIENT OUTCOMES BASED ON DONOR AGE IN A CONTEMPORARY CANADIAN COHORT

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Neal Rowe ◽  
Melissa Huynh ◽  
Phillippe Violette ◽  
Corinne Weernink ◽  
Alp Sener ◽  
...  
Keyword(s):  
Donation After Circulatory Death ◽  
Donor Age ◽  
Renal Allografts ◽  
Circulatory Death

Donation after Circulatory Death Renal Allografts—Does Donor Age Greater than 50 Years Affect Recipient Outcomes?

2015 ◽  
Vol 194 (4) ◽  
pp. 1057-1061
Author(s):  
Melissa J. Huynh ◽  
Philippe D. Violette ◽  
Neal E. Rowe ◽  
Corinne Weernink ◽  
Kelly MacLean ◽  
...  
Keyword(s):  
Donation After Circulatory Death ◽  
Donor Age ◽  
Renal Allografts ◽  
Circulatory Death

Quantifying Cardiac Injury with Donation after Circulatory Death Process: Impact of Donor Age and Obesity

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Oluwatoyin Elizabeth Akande ◽  
Qun Chen ◽  
Stefano Toldo ◽  
Edward Lesnefsky ◽  
Mohammed Quader
Keyword(s):  
Cardiac Injury ◽  
Death Process ◽  
Donation After Circulatory Death ◽  
Donor Age ◽  
Circulatory Death

scholarly journals The Effect of Increasing Donor Age on Myocardial Ischemic Tolerance in a Rodent Model of Donation After Circulatory Death

2021 ◽  
Vol 7 (6) ◽  
pp. e699
Author(s):  
Jeanette E. Villanueva ◽  
Hong C. Chew ◽  
Ling Gao ◽  
Aoife Doyle ◽  
Sarah E. Scheuer ◽  
...  
Keyword(s):  
Ischemic Tolerance ◽  
Rodent Model ◽  
Donation After Circulatory Death ◽  
Donor Age ◽  
Circulatory Death

scholarly journals Intraoperative Verapamil Fails to Reduce Delayed Graft Function in Donation After Circulatory Death Renal Allografts

2022 ◽  
Vol 8 (2) ◽  
pp. e1250
Author(s):  
Jessica T. Lovett ◽  
Jeffrey Stern ◽  
Elaina P. Weldon ◽  
Bonnie E. Lonze ◽  
Zoe A. Stewart
Keyword(s):  
Graft Function ◽  
Delayed Graft Function ◽  
Donation After Circulatory Death ◽  
Renal Allografts ◽  
Circulatory Death

The Impact of CPR in High-Risk Donation after Circulatory Death Donors and Extended Criteria Donors for Kidney Transplantation

2018 ◽  
Vol 84 (7) ◽  
pp. 1164-1168
Author(s):  
Jacentha Buggs ◽  
Ebonie Rogers ◽  
Victor Bowers
Keyword(s):  
Kidney Transplantation ◽  
High Risk ◽  
Graft Survival ◽  
Donation After Circulatory Death ◽  
Extended Criteria Donors ◽  
Significant Difference ◽  
Cadaveric Donors ◽  
The Impact ◽  
Circulatory Death

The demand for organs for kidney transplantation (KTX) compels the use of high-risk donation after circulatory death donors (DCDs) and extended criteria donors (ECDs). Many deceased donors receive prehospital CPR, but the literature does not address CPR as a benefit to graft survival. We hypothesized that donor prehospital CPR correlates with improved graft survival with high-risk DCD/ECD kidneys. We retrospectively analyzed KTX recipients and their donor data from 2008 to 2013. A total of 646 cadaveric donors (498 SCDs, 55 DCDs, and 93 ECDs) facilitated 910 KTX. There were 223 KTX performed from 148 high-risk DCDs/ECDs (31 with CPR and 117 without CPR). The mean age of high-risk DCDs/ECDs with CPR was 44.94 versus 53.45 years without CPR (P = 0.005). The recipients of high-risk DCDs/ECDs revealed no significant difference in body mass index, length of stay, discharge Cr, CIT, or DGF with and without CPR. Graft survival at three years was significant with 0/50 failures from high-risk DCDs/ECDs with CPR versus 16/173 without CPR (P = 0.026). Our findings are limited as a single-center retrospective study; however, the result of significant three-year graft survival in high-risk DCDs/ECDs with CPR suggests that prehospital donor CPR should be further investigated for its contribution to the relative quality of the donor.

scholarly journals Donor Age, Cold Ischemia Time, and Delayed Graft Function

2020 ◽  
Vol 15 (6) ◽  
pp. 813-821 ◽  
Author(s):  
Ilkka Helanterä ◽  
Hassan N. Ibrahim ◽  
Marko Lempinen ◽  
Patrik Finne
Keyword(s):  
Graft Function ◽  
The United States ◽  
Delayed Graft Function ◽  
Cold Ischemia Time ◽  
Donation After Circulatory Death ◽  
Donor Age ◽  
Cold Ischemia ◽  
Kidney Donor ◽  
Ischemia Time ◽  
Circulatory Death

Background and objectivesIncreased donor age is one of the most important risk factors for delayed graft function (DGF), and previous studies suggest that the harmful effect of cold ischemia time is increased in kidneys from older donors. Our aim was to study the association of increased donor age and cold ischemia time with the risk of delayed graft function in a large cohort kidney transplants from the current era.Design, setting, participants, & measurementsThe Scientific Registry of Transplant Recipients was used for this observational, retrospective registry analysis to identify all deceased donor kidney transplantations in the United States between 2010 and September 2018, who were on dialysis pretransplantation (n=90,810). The association of donor age and cold ischemia time with the risk of DGF was analyzed in multivariable models adjusted for recipient characteristics (age, race, sex, diabetes, calculated panel-reactive antibodies, pretransplant dialysis duration) and donor characteristics (cause of death, sex, race, body mass index, creatinine, donation after circulatory death status, history of hypertension, and HLA mismatch).ResultsCold ischemia time and donor age were independently associated with the risk of DGF, but the risk of DGF was not statistically significantly lower in donor age categories between 50 and 64 years, compared with donors ≥65 years. The harmful association of cold ischemia time was not higher in kidneys from older donors in any age category, not even among donation after circulatory death donors. When donor risk was assessed with kidney donor profile index, although a statistically significant interaction with cold ischemia time was found, no practically meaningful increase in cold-ischemia susceptibility of kidneys with a high kidney donor profile index was found.ConclusionsWe were unable to demonstrate an association between donor age and DGF. The association of longer cold ischemia time with the risk of DGF was not magnified in older or more marginal donors.

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