Effects of Spinal Cord Ischemia on Evoked Potential Recovery and Postischemic Regional Spinal Cord Blood Flow

1993 ◽  
Vol 6 (2) ◽  
pp. 146???154
Author(s):  
Richard K. Osenbach ◽  
Patrick W. Hitchon ◽  
Loren Mouw ◽  
Thoru Yamada
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Evoked Potential ◽  
Spinal Cord Ischemia ◽  
Spinal Cord Blood Flow

Effects of Spinal Cord Ischemia on Evoked Potential Recovery and Postischemic Regional Spinal Cord Blood Flow

1993 ◽  
Vol 6 (2) ◽  
pp. 146???154 ◽  
Author(s):  
Richard K. Osenbach ◽  
Patrick W. Hitchon ◽  
Loren Mouw ◽  
Thoru Yamada
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Evoked Potential ◽  
Spinal Cord Ischemia ◽  
Spinal Cord Blood Flow

scholarly journals Spinal Cord Blood Flow after Ischemic Preconditioning in a Rat Model of Spinal Cord Ischemia

2004 ◽  
Vol 4 ◽  
pp. 892-898 ◽  
Author(s):  
David Zvara ◽  
James M. Zboyovski ◽  
Dwight D. Deal ◽  
Jason C. Vernon ◽  
David M. Colonna
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Ischemic Preconditioning ◽  
Spinal Cord Ischemia ◽  
Flow Analysis ◽  
Lumbar Spinal Cord ◽  
Sprague Dawley ◽  
Spinal Cord Blood Flow ◽  
Significant Difference

Spinal cord blood flow after ischemic preconditioning is poorly characterized. This study is designed to evaluate spinal cord blood flow patterns in animals after acute ischemic preconditioning. Experiment 1: After a laminectomy and placement of a laser Doppler probe over the lumbar spinal cord to measure spinal cord blood flow, 16 male Sprague-Dawley rats were randomized into two groups: ischemic preconditioning (IPC, n = 8), and control (CTRL, n = 8). Rats in the CTRL and the IPC groups were subjected to 12 min of ischemia directly followed by 60 min of reperfusion. IPC rats received 3 min of IPC and 30 min of reperfusion prior to the 12-min insult period. Experiment 2: After instrumentation, the rats were randomized into three groups: control (CTRL, n = 7), ischemic preconditioning (IPC, n = 7), and time control (TC, n = 4). Rats in the CTRL and the IPC groups were subjected to the same ischemia and reperfusion protocol as above. The TC group was anesthetized for the same time period as the CTRL and the IPC groups, but had no ischemic intervention. Microspheres were injected at baseline and at 15 and 60 min into the final reperfusion. All rats were euthanized and tissue harvested for spinal cord blood flow analysis. In Experiment 1, there was a slight, significant difference in spinal cord blood flow during the ischemic period; however, this difference soon disappeared during reperfusion. In experiment 2, there was no difference in blood flow at any experimental time. The results of these experiments demonstrate that IPC slightly enhances blood flow to the spinal cord during ischemia; however, this effect is not sustained during the reperfusion period.

scholarly journals Towards rapid intraoperative axial localization of spinal cord ischemia with epidural diffuse correlation monitoring

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251271
Author(s):  
David R. Busch ◽  
Wei Lin ◽  
Chia Chieh Goh ◽  
Feng Gao ◽  
Nicholas Larson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Spinal Cord Ischemia ◽  
Correlation Spectroscopy ◽  
Spinal Cord Blood Flow ◽  
Doppler Flowmetry ◽  
Spatially Resolved ◽  
Highly Correlated ◽  
Sensitivity Specificity

Spinal cord ischemia leads to iatrogenic injury in multiple surgical fields, and the ability to immediately identify onset and anatomic origin of ischemia is critical to its management. Current clinical monitoring, however, does not directly measure spinal cord blood flow, resulting in poor sensitivity/specificity, delayed alerts, and delayed intervention. We have developed an epidural device employing diffuse correlation spectroscopy (DCS) to monitor spinal cord ischemia continuously at multiple positions. We investigate the ability of this device to localize spinal cord ischemia in a porcine model and validate DCS versus Laser Doppler Flowmetry (LDF). Specifically, we demonstrate continuous (>0.1Hz) spatially resolved (3 locations) monitoring of spinal cord blood flow in a purely ischemic model with an epidural DCS probe. Changes in blood flow measured by DCS and LDF were highly correlated (r = 0.83). Spinal cord blood flow measured by DCS caudal to aortic occlusion decreased 62%. This monitor demonstrated a sensitivity of 0.87 and specificity of 0.91 for detection of a 25% decrease in flow. This technology may enable early identification and critically important localization of spinal cord ischemia.

scholarly journals Spatially resolved optical monitoring of spinal cord blood flow with a minimally invasive, multi-level epidural probe

2020 ◽  
Author(s):  
David R. Busch ◽  
Wei Lin ◽  
Chia Chieh Goh ◽  
Feng Gao ◽  
Nicholas Larson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Spinal Cord Ischemia ◽  
Correlation Spectroscopy ◽  
Spinal Cord Blood Flow ◽  
Doppler Flowmetry ◽  
Spatially Resolved ◽  
Highly Correlated ◽  
Sensitivity Specificity

AbstractSpinal cord ischemia leads to iatrogenic injury in multiple surgical fields, and the ability to immediately identify onset and anatomic origin of ischemia is critical to its management. Current clinical monitoring, however, does not directly measure spinal cord blood flow, resulting in poor sensitivity/specificity, delayed alerts, and delayed intervention. We have developed an epidural device employing diffuse correlation spectroscopy (DCS) to monitor spinal cord ischemia continuously at multiple positions. We investigate the ability of this device to localize spinal cord ischemia in a porcine model and validate DCS versus Laser Doppler Flowmetry (LDF).Specifically, we demonstrate continuous (>0.1Hz) spatially resolved (3 locations) monitoring of spinal cord blood flow in a purely ischemic model with an epidural DCS probe. Changes in blood flow measured by DCS and LDF were highly correlated (r=0.83). Spinal cord blood flow measured by DCS caudal to aortic occlusion decreased 62%, with a sensitivity of 0.87 and specificity of 0.91 for detection of a 25% decrease in flow. This technology may enable early identification and critically important localization of spinal cord ischemia.

Spinal cord blood flow and conduction during experimental cord compression in normotensive and hypotensive dogs

1979 ◽  
Vol 50 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Ian R. Griffiths ◽  
James G. Trench ◽  
Robert A. Crawford
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Evoked Potential ◽  
Cord Compression ◽  
Dorsal Column ◽  
Spinal Cord Blood Flow ◽  
Content Type ◽  
Strain Gauge Transducer ◽  
Conduction Failure

✓ Spinal cord blood flow (SCBF) and dorsal column conduction, as assessed by the dorsal column evoked potential (DCEP), were measured during subacute cord compression in dogs. Ventral, midline balloons were used to produce compression and a dorsally situated strain gauge transducer measured the cord pressure. In normotensive animals there was autoregulation of SCBF to perfusion pressures (PP) of 65 to 70 mm Hg, and up to cord pressures of 55 to 60 mm Hg. The DCEP amplitude was significantly decreased even during this autoregulatory period. Conduction failure occurred at PP of 20 to 30 mm Hg. Chemically produced hypotension (74 mm Hg) did not affect either SCBF or DCEP. Minimal compression superimposed on hypotension decreased both flow and DCEP amplitude. The results indicate that ischemia is probably not the cause of the impaired conduction although, as the degree of compression increases, the cord will become ischemic once the autoregulatory limit is passed.

Spinal Cord Blood Flow and Pathophysiological Changes after Transient Spinal Cord Ischemia in Cats

Neurosurgery ◽  
1998 ◽  
Vol 42 (3) ◽  
pp. 626-634 ◽  
Author(s):  
Yamada Tomonori ◽  
Morimoto Tetsuya ◽  
Nakase Hiroyuki ◽  
Hirabayashi Hidehiro ◽  
Hiramatsu Ken-ichiro ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Spinal Cord Ischemia ◽  
Spinal Cord Blood Flow
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