CD4+CD8+ and CD8α+β- T lymphocytes in human small intestinal lamina propria

1998 ◽  
Vol 10 (4) ◽  
pp. 325-330 ◽  
Author(s):  
Mohamed Abuzakouk ◽  
Janet Carton ◽  
Conleth Feighery ◽  
Diarmuid P. OʼDonoghue ◽  
Donald G. Weir ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Lamina Propria ◽  
Intestinal Lamina Propria ◽  
Small Intestinal

Crossover Subsets of CD4+ T Lymphocytes in the Intestinal Lamina Propria of Patients with Crohn’s Disease and Ulcerative Colitis

2017 ◽  
Vol 62 (9) ◽  
pp. 2357-2368 ◽  
Author(s):  
Ji Li ◽  
Aito Ueno ◽  
Marietta Iacucci ◽  
Miriam Fort Gasia ◽  
Humberto B. Jijon ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
T Lymphocytes ◽  
Crohn's Disease ◽  
Lamina Propria ◽  
Intestinal Lamina Propria

[20] Redox processes regulate intestinal lamina propria T lymphocytes

2002 ◽  
pp. 232-247 ◽  
Author(s):  
Bernd Sido ◽  
Raoul Breitkreutz ◽  
Cornelia Seel ◽  
Christian Herfarth ◽  
Stefan Meuer
Keyword(s):  
T Lymphocytes ◽  
Lamina Propria ◽  
Redox Processes ◽  
Intestinal Lamina Propria

Phenotype of HML-1-Positive and HML-1-Negative T Lymphocytes in the Human Intestinal Lamina Propria

1995 ◽  
pp. 77-79
Author(s):  
Henrike L. Schieferdecker ◽  
Daniela C. Schmidt ◽  
Reiner Ullrich ◽  
Hans-Ulrich Jahn ◽  
Heike Hirseland ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Lamina Propria ◽  
Intestinal Lamina Propria

scholarly journals Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

2009 ◽  
Vol 206 (13) ◽  
pp. 3047-3059 ◽  
Author(s):  
Melba Muñoz ◽  
Markus M. Heimesaat ◽  
Kerstin Danker ◽  
Daniela Struck ◽  
Uwe Lohmann ◽  
...  
Keyword(s):  
T Cells ◽  
Toxoplasma Gondii ◽  
Lamina Propria ◽  
Th17 Cells ◽  
Intestinal Inflammation ◽  
Gelatinase A ◽  
Intestinal Lamina Propria ◽  
Small Intestinal ◽  
Th1 Cytokines

Peroral infection with Toxoplasma gondii leads to the development of small intestinal inflammation dependent on Th1 cytokines. The role of Th17 cells in ileitis is unknown. We report interleukin (IL)-23–mediated gelatinase A (matrixmetalloproteinase [MMP]-2) up-regulation in the ileum of infected mice. MMP-2 deficiency as well as therapeutic or prophylactic selective gelatinase blockage protected mice from the development of T. gondii–induced immunopathology. Moreover, IL-23–dependent up-regulation of IL-22 was essential for the development of ileitis, whereas IL-17 was down-regulated and dispensable. CD4+ T cells were the main source of IL-22 in the small intestinal lamina propria. Thus, IL-23 regulates small intestinal inflammation via IL-22 but independent of IL-17. Gelatinases may be useful targets for treatment of intestinal inflammation.

Sign in / Sign up

Export Citation Format

Share Document