EZ Glide Aortic Cannula

2020 ◽  
Vol 50 (3) ◽  
pp. 20
Keyword(s):  
Aortic Cannula

Independent dual perfusion of left and right coronary arteries in isolated rat hearts

1991 ◽  
Vol 261 (6) ◽  
pp. H2082-H2090 ◽  
Author(s):  
M. Avkiran ◽  
M. J. Curtis
Keyword(s):  
High Energy ◽  
Low Flow ◽  
Blue Dye ◽  
Ischemia And Reperfusion ◽  
Langendorff Preparation ◽  
Rat Hearts ◽  
Left And Right ◽  
Conventional Models ◽  
Aortic Cannula ◽  
Isolated Rat

A novel dual lumen aortic cannula was designed and constructed to permit independent perfusion of left and right coronary beds in isolated rat hearts without necessitating the cannulation of individual arteries. Stability of the dual-perfusion preparation was shown to be similar to that of the conventional Langendorff preparation, in terms of coronary flow, heart rate, and high-energy phosphate content. The independence of left and right perfusion beds was confirmed by unilateral infusion of disulfine blue dye and spectrophotometric detection of the dye in ventricular homogenates. Transient cessation of flow to the left coronary bed resulted in severe ventricular arrhythmias upon reperfusion, as in conventional models of regional ischemia and reperfusion. The dual-perfusion model is technically undemanding, reproducible, inexpensive, and can be used in several species. It enables studies with 1) regional low flow ischemia, 2) regional zero-flow ischemia without coronary ligation (with attendant damage to vasculature), 3) selective application of drugs or interventions to the ischemic-reperfused zone, and 4) selective application of components of ischemia and reperfusion to a site anatomically relevant to ischemic heart disease.

Brain microembolic counts during extracorporeal circulation depend on aortic cannula position

2001 ◽  
Vol 27 (7) ◽  
pp. 933-936 ◽  
Author(s):  
Wolfgang Ml̈lges ◽  
Dorothea Franke ◽  
Wilko Reents ◽  
Jr̈g Babin-Ebell
Keyword(s):  
Extracorporeal Circulation ◽  
Aortic Cannula

Development of Pressure Gradient between Radial and Femoral Artery due to Aortic Cannula Malposition in Pediatric Cardiac Surgery

1998 ◽  
Vol 35 (6) ◽  
pp. 1124
Author(s):  
Eun Sook Yoo ◽  
Young Lan Kwak ◽  
Sang Beom Nam ◽  
Won Sun Park ◽  
Dong Woo Han ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Pressure Gradient ◽  
Femoral Artery ◽  
Pediatric Cardiac Surgery ◽  
Aortic Cannula

THE INTERACTION OF BLOOD ELEMENTS WITH ENDOCARDIAL ENDOTHELIUM DAMAGED BY LACTIC ACID

1987 ◽  
Author(s):  
G Carter ◽  
B J Gavin
Keyword(s):  
Lactic Acid ◽  
Basal Lamina ◽  
Myocardial Infarct ◽  
Transmission Electron ◽  
Rat Hearts ◽  
Cacodylate Buffer ◽  
Aortic Cannula ◽  
Endocardial Endothelium

It has already been demonstrated that ischaemic metabolites, which could diffuse frcm a myocardial infarct in vivo, can cause substantial damage to the endocardial endotheliun and this could predispose to mural thrombosis.To investigate the role of ischaemic metabolites in the pathogenesis of mural thrombosis, lactic acid (pH6.4) was passed through a two-way concentric catheter ligated into the left ventricle of isolated beating rat hearts that were perfused with oxygenated Krebs-Henseleit buffer (KHB) through an aortic cannula. After periods of 1, 2, and 4 hours, the lactic acid was followed for 10 minutes by 10 mis of whole blood from hepa-rinized donor rats. Ventricles were then flushed with KHB, fixed in 2.5% glutaraldehyde and post-fixed in 1% osmium tetrox-ide in cacodylate buffer.Scanning and transmission electron microscopy showed that platelets adhered to exposed basal lamina, microfibrils and collagen but not to intact or damaged endothelial cells. However densely aggregated thrombi only farmed on regions of exposed connective tissue and never on basal lamina. Fibrin, leukocytes and red blood cells were associated with these platelet thrombi. Thus lactic acid and other ischaemic metabolites which could possibly diffuse in vivo from an infarct can contribute to endocardial damage which predisposes to mural thrombosis.

Transaortic Endoclamp for Mitral Valve Operation through Right Minithoracotomy in 369 Patients

2010 ◽  
Vol 5 (6) ◽  
pp. 394-399 ◽  
Author(s):  
Donald D. Glower ◽  
Bhargavi Desai
Keyword(s):  
Mitral Valve ◽  
Ascending Aorta ◽  
Intercostal Space ◽  
Safe Alternative ◽  
Aortic Clamping ◽  
Mitral Valve Operation ◽  
Group A ◽  
Aortic Cannula ◽  
Group B ◽  
Valve Operation

Objective The effects and benefits of a transaortic endoclamp for mitral valve operation through right minithoracotomy have not been established. Methods The records were examined in 671 patients undergoing mitral valve operation using aortic cannulation through a 6-cm right minithoracotomy in the fourth intercostal space. The ascending aorta was cannulated with a 24-Fr cannula through a 12-mm port in the first intercostal space. The experience from 1998 to 2006 with aortic endoclamping (group A, N = 436) was compared with the experience from 2006 to 2009 with external aortic clamping (group B, N = 235). Aortic endoclamping was achieved with a 30 mL endoclamp introduced through the aortic cannula into the ascending aorta to provide aortic endoclamping, anterograde cardioplegia, and root venting. Percutaneous femoral venous cannulation was used. Results Group A and group B had similar demographics. Endoclamp availability (group A) resulted in significantly less fibrillatory arrest (no clamping) in 67 of 436 (15%) versus 104 of 235 (44%) patients in group B (P = 0.001). In patients with aortic clamping, endoclamp (group A) versus external clamp (group B) was not a determinant of clamp time or pump time. Hospital and late outcomes were not different between groups. No patient complications could be attributed to the endoclamp. Conclusions Aortic endoclamping requires no more clamp or pump time than external clamping and can provide a more bloodless field than ventricular fibrillation without obstructing hardware. Aortic endoclamping is a safe alternative for mitral surgery through right minithoracotomy.

scholarly journals Disconnection of the tip of the aortic cannula during cardiopulmonary bypass

2008 ◽  
Vol 8 (2) ◽  
pp. 250-251
Author(s):  
R. S. Singh ◽  
H. Singh ◽  
V. Sharma ◽  
S. Mahajan
Keyword(s):  
Cardiopulmonary Bypass ◽  
Aortic Cannula

scholarly journals Mitochondrial transplantation for myocardial protection in diabetic hearts

2019 ◽  
Vol 57 (5) ◽  
pp. 836-845 ◽  
Author(s):  
Ilias P Doulamis ◽  
Alvise Guariento ◽  
Thomas Duignan ◽  
Arzoo Orfany ◽  
Takashi Kido ◽  
...  
Keyword(s):  
Diastolic Pressure ◽  
Ex Vivo ◽  
Left Ventricular ◽  
Diabetic Rat ◽  
Ischaemia Reperfusion Injury ◽  
Global Ischaemia ◽  
Aortic Cannula ◽  
Developed Pressure ◽  
Perfused Hearts

Abstract OBJECTIVES Type 2 diabetes causes mitochondrial dysfunction, which increases myocardial susceptibility to ischaemia–reperfusion injury. We investigated the efficacy of transplantation of mitochondria isolated from diabetic or non-diabetic donors in providing cardioprotection from warm global ischaemia and reperfusion in the diabetic rat heart. METHODS Ex vivo perfused hearts from Zucker diabetic fatty (ZDF fa/fa) rats (n = 6 per group) were subjected to 30 min of warm global ischaemia and 120 min reperfusion. Immediately prior to reperfusion, vehicle alone (VEH) or vehicle containing mitochondria isolated from either ZDF (MTZDF) or non-diabetic Zucker lean (ZL +/?) (MTZL) skeletal muscle were delivered to the coronary arteries via the aortic cannula. RESULTS Following 30-min global ischaemia and 120-min reperfusion, left ventricular developed pressure was significantly increased in MTZDF and MTZL groups compared to VEH group (MTZDF: 92.8 ± 5.2 mmHg vs MTZL: 110.7 ± 2.4 mmHg vs VEH: 44.3 ± 5.9 mmHg; P < 0.01 each); and left ventricular end-diastolic pressure was significantly decreased (MTZDF 12.1 ± 1.3 mmHg vs MTZL 8.6 ± 0.8 mmHg vs VEH: 18.6 ± 1.5 mmHg; P = 0.016 for MTZDF vs VEH and P < 0.01 for MTZL vs VEH). Total tissue ATP content was significantly increased in both MT groups compared to VEH group (MTZDF: 18.9 ± 1.5 mmol/mg protein/mg tissue vs MTZL: 28.1 ± 2.3 mmol/mg protein/mg tissue vs VEH: 13.1 ± 0.5 mmol/mg protein/mg tissue; P = 0.018 for MTZDF vs VEH and P < 0.01 for MTZL vs VEH). Infarct size was significantly decreased in the MT groups (MTZDF: 11.8 ± 0.7% vs MTZL: 9.9 ± 0.5% vs VEH: 52.0 ± 1.4%; P < 0.01 each). CONCLUSIONS Mitochondrial transplantation significantly enhances post-ischaemic myocardial functional recovery and significantly decreases myocellular injury in the diabetic heart.

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