[PP.20.11] VENTRICULAR-ARTERIAL COUPLING AND VENTRICULAR EFFICIENCY AT REST AND DURING HANDGRIP ISOMETRIC EXERCISE IN UNTREATED HYPERTENSIVE PATIENTS

2016 ◽  
Vol 34 ◽  
pp. e242
Author(s):  
A. Bogomaz ◽  
Y. Kotovskaya ◽  
Z. Kobalava
Keyword(s):  
Isometric Exercise ◽  
Hypertensive Patients ◽  
Ventricular Efficiency

The Effects of Hypertension and Aging on Left Ventricular Function during Isometric Exercise

1996 ◽  
Vol 4 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Michael Sagiv ◽  
Amira Sagiv ◽  
David Ben-Sira ◽  
Jacob Rudoy ◽  
Michael Soudry
Keyword(s):  
Systolic Function ◽  
Maximum Voluntary Contraction ◽  
Isometric Exercise ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Voluntary Contraction ◽  
Chronic Hypertension ◽  
Ventricular Systolic Function ◽  
Hypertensive Patients ◽  
Effects Of Aging

Hemodynamic and left ventricular systolic function were studied by Doppler echocardiography in 14 young and 15 older adult hypertensive patients and in 15 young and 12 older normotensive individuals. Measures were made at rest and during upright deadlift isometric exercise, at 30% of maximum voluntary contraction for 3 min. At rest, young and older hypertensive patients demonstrated impaired left ventricular systolic function compared to both old and young normotensive subjects. The impaired systolic function was associated with less augmentation in systolic indices during exercise compared with resting values in young and elderly hypertensive patients, and to a lesser degree in the normotensive elderly when compared with young normotensives. These data indicate that at rest, left ventricular systolic function may be compromised in hypertensive patients with left ventricular hypertrophy and, to a lesser extent, in the normotensive elderly. However, other factors in chronic hypertension may contribute to abnormal systolic function and override the effects of aging alone.

Combined Pre- and after-Load Reduction in Hypertensive Patients with Cardiomegaly and Normal Filling Pressure

1981 ◽  
Vol 61 (s7) ◽  
pp. 113s-116s ◽  
Author(s):  
S. N. Hunyor ◽  
G. I. Nelson ◽  
G. L. Donnelly
Keyword(s):  
Cardiac Output ◽  
Systemic Vascular Resistance ◽  
Vascular Resistance ◽  
Isometric Exercise ◽  
Left Ventricular ◽  
Filling Pressure ◽  
Load Reduction ◽  
Blocking Drug ◽  
Isometric Handgrip ◽  
Hypertensive Patients

1. Twelve hypertensive patients with cardiomegaly were treated with equivalent antihypertensive doses of prazosin (11 weeks) and β-adrenoceptor-blocking drug (9 weeks) in random crossover fashion. 2. At the end of each treatment period haemodynamic assessment included the response to isometric handgrip exercise (4 min at 30% of maximum voluntary contraction). 3. Resting cardiac index and heart rate were higher on prasozin although the latter was only 65 beats/min. Systemic vascular resistance and left ventricular filling pressure were insignificantly higher on β-adrenoceptor-blocking drug. 4. During isometric handgrip the blood pressure rise was similar on the two regimens, but the mechanism whereby it was achieved was quite different. On prazosin an increase in cardiac output accounted for the pressor response with virtually no change in systemic vascular resistance, whereas on β blockade there was a flat cardiac output response with a marked increase in the systemic vascular resistance. 5. Ventricular function curves indicated a predominant utilization of the Frank-Starling mechanism during β blockade, whereas enhanced contractility played a major role during prazosin treatment. 6. The isometric exercise response pattern during prazosin treatment resembles that in normal subjects whereas in the β blockade phase it corresponded to that in untreated hypertensive patients with left ventricular hypertrophy or cardiomegaly or to that in congestive heart failure patients. 7. There was no evidence of harmful effects of combined pre- and after-load reduction in hypertensive patients with cardiomegaly and normal filling pressure, even under conditions of moderately severe cardiac loading with isometric exercise.

scholarly journals Is Low-Intensity Isometric Handgrip Exercise an Efficient Alternative in Lifestyle Blood Pressure Management? A Systematic Review

2020 ◽  
Vol 12 (5) ◽  
pp. 470-477 ◽  
Author(s):  
Andrés F. Loaiza-Betancur ◽  
Iván Chulvi-Medrano
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Isometric Exercise ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Handgrip Exercise ◽  
Isometric Handgrip ◽  
Hypertensive Patients ◽  
Low Intensity ◽  
Isometric Handgrip Exercise

Context: High blood pressure is one of the leading preventable causes of cardiovascular death worldwide. In this regard, several studies have shown interest in the benefits of isometric exercise on blood pressure regulation. Objective: To assess whether low-intensity isometric handgrip exercise (LI-IHE) is an effective strategy to lower blood pressure levels in prehypertensive and hypertensive patients. Data Source: This study was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and registered with PROSPERO. Potentially eligible studies were identified after a systematic search conducted on 4 international databases: PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), PEDro, and SPORTDiscus. Study Selection: We included randomized controlled trials that comprised patients who received LI-IHE. Study Design: Systematic review with meta-analysis. Level of Evidence: Level 3. Data Extraction: Data related to patient characteristics, exercise programs, risk-of-bias assessment, and outcomes of interest were systematically reviewed independently by 2 authors. Results: The following reductions (mean differences) were observed after LI-IHE: systolic blood pressure (SBP), (MD) = −5.43 mm Hg; (95% CI, −8.47 to −2.39; P = 0.0005); diastolic blood pressure (DBP), −2.41 mm Hg (95% CI, −4.33 to −0.48; P = 0.01); mean arterial pressure (MAP), −1.28 mm Hg (95% CI, −2.99 to 0.44; P = 0.14). Conclusion: LI-IHE seems to lower SBP, DBP, and MAP values in prehypertensive and hypertensive adults. It appears that LI-IHE reduces, in greater magnitude, blood pressure levels in hypertensive patients, specifically in patients aged <45 years, those who are overweight, and those on medications. Nevertheless, substantial heterogeneity in the main results and in the analyses by subgroups generated uncertainty about the real reduction magnitude that LI-IHE can produce on blood pressure.

scholarly journals Neurohumoral and ambulatory haemodynamic adaptations following isometric exercise training in unmedicated hypertensive patients

2019 ◽  
Vol 37 (4) ◽  
pp. 827-836 ◽  
Author(s):  
Katrina A. Taylor ◽  
Jonathan D. Wiles ◽  
Damian A. Coleman ◽  
Paul Leeson ◽  
Rajan Sharma ◽  
...  
Keyword(s):  
Exercise Training ◽  
Isometric Exercise ◽  
Hypertensive Patients

Labetalol in Hypertensive Patients with Angina Pectoris: Beneficial Effect of Combined α- and β-Adrenoreceptor Blockade

1978 ◽  
Vol 55 (s4) ◽  
pp. 283s-286s
Author(s):  
W. F. Lubbe ◽  
D. A. White
Keyword(s):  
Blood Pressure ◽  
Angina Pectoris ◽  
Isometric Exercise ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Hypertensive Patients ◽  
Isotonic Exercise ◽  
Final Treatment ◽  
Stepwise Reduction ◽  
Blood Pressures

1. Eight hypertensive patients with angina pectoris had placebo added to their existing medications for 8 weeks, then incremental doses of active labetalol with simultaneous stepwise reduction in other medicines until blood pressure was satisfactorily controlled; after that only labetalol and thiazide (8 weeks) and finally labetalol-placebo together with previous β-adrenoreceptor antagonists and thiazide for 4 weeks were administered. 2. During the labetalol plus thiazide period resting blood pressures and measurements obtained during isotonic exercise, isometric exercise and the cold pressor test were significantly lower than during the initial placebo addition period. Angina scores were significantly reduced during this period. 3. During the final treatment with placebo, β-adrenoreceptor antagonist and thiazide, blood pressures remained reduced, but angina was significantly worse. 4. Labetalol which antagonizes both α- and β-adrenoreceptors produced better relief of angina pectoris than β-adrenoreceptor antagonists during improvement in blood pressure in hypertensive patients.

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