[BP.07.06] ACUTE ADMINISTRATION (SINGLE DOSE) OF BEETROOT JUICE ATTENUATES BLOOD PRESSURE DURING ISOMETRIC EXERCISE IN UNTREATED HYPERTENSIVE PATIENTS

2017 ◽  
Vol 35 ◽  
pp. e265
Author(s):  
A. Triantafyllou ◽  
A. Zafeiridis ◽  
S. Papadopoulos ◽  
N. Koletsos ◽  
E. Gkaliagkousi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Single Dose ◽  
Isometric Exercise ◽  
Acute Administration ◽  
Beetroot Juice ◽  
Hypertensive Patients

Abstract 14387: Dose-Related Reductions in Blood Pressure With a RNA Interference (RNAi) Therapeutic Targeting Angiotensinogen in Hypertensive Patients: Interim Results From a First-In-Human Phase 1 Study of ALN-AGT01

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Stephen A Huang ◽  
Jorg Taubel ◽  
Giuseppe Fiore ◽  
Peter Dewland ◽  
George L Bakris ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Single Dose ◽  
Adverse Events ◽  
Phase 1 ◽  
Serious Adverse Events ◽  
Therapeutic Targeting ◽  
Dose Administration ◽  
Hypertensive Patients ◽  
Single Dose Administration ◽  
Angiotensin Peptides

Background: Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides and plays a key role in hypertension pathogenesis. We evaluated the effect of ALN-AGT01, a subcutaneous investigational RNAi therapeutic targeting hepatic AGT synthesis, on blood pressure in hypertensive patients. Methods: As part of a phase 1 program designed to assess the safety and tolerability of ALN-AGT01, we conducted a multicenter study randomizing patients aged 18-65 years with mild to moderate hypertension (mean seated systolic blood pressure [SBP] of >130 and ≤165 mmHg after washout of antihypertensive medication) 2:1 to ascending single doses of ALN-AGT01 or placebo. Change from baseline in BP at 8 weeks was measured by ambulatory BP monitoring (ABPM). We report interim results as of May 14, 2020. Results: Sixty patients (mean age 52 years, 45% female, mean baseline 24h SBP 139 +/- 7 mm Hg) were enrolled in ascending dose cohorts of 10 mg, 25 mg, 50 mg, 100 mg, or 200 mg. Dose-related reductions in serum AGT levels were observed (figure), with reductions >90% in the 100 and 200 mg dose cohorts. AGT remained durably reduced through 12 weeks after single dose administration. Concomitant reductions in BP from baseline were observed with AGT knockdown, with an over 10 mm Hg reduction of mean 24-hour SBP observed at Week 8 after single doses of 100 mg or 200 mg. No symptomatic hypotension, treatment-related serious adverse events, or clinically significant elevations in blood creatinine or potassium were seen. Conclusions: Single dose administration of ALN-AGT01 to hypertensive patients resulted in dose-related reductions in serum AGT and BP over 8 weeks without hypotension or other related serious adverse events. Durable AGT knockdown to 12 weeks supports further evaluation of once quarterly or potentially less frequent dose administration.

scholarly journals Is Low-Intensity Isometric Handgrip Exercise an Efficient Alternative in Lifestyle Blood Pressure Management? A Systematic Review

2020 ◽  
Vol 12 (5) ◽  
pp. 470-477 ◽  
Author(s):  
Andrés F. Loaiza-Betancur ◽  
Iván Chulvi-Medrano
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Isometric Exercise ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Handgrip Exercise ◽  
Isometric Handgrip ◽  
Hypertensive Patients ◽  
Low Intensity ◽  
Isometric Handgrip Exercise

Context: High blood pressure is one of the leading preventable causes of cardiovascular death worldwide. In this regard, several studies have shown interest in the benefits of isometric exercise on blood pressure regulation. Objective: To assess whether low-intensity isometric handgrip exercise (LI-IHE) is an effective strategy to lower blood pressure levels in prehypertensive and hypertensive patients. Data Source: This study was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and registered with PROSPERO. Potentially eligible studies were identified after a systematic search conducted on 4 international databases: PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), PEDro, and SPORTDiscus. Study Selection: We included randomized controlled trials that comprised patients who received LI-IHE. Study Design: Systematic review with meta-analysis. Level of Evidence: Level 3. Data Extraction: Data related to patient characteristics, exercise programs, risk-of-bias assessment, and outcomes of interest were systematically reviewed independently by 2 authors. Results: The following reductions (mean differences) were observed after LI-IHE: systolic blood pressure (SBP), (MD) = −5.43 mm Hg; (95% CI, −8.47 to −2.39; P = 0.0005); diastolic blood pressure (DBP), −2.41 mm Hg (95% CI, −4.33 to −0.48; P = 0.01); mean arterial pressure (MAP), −1.28 mm Hg (95% CI, −2.99 to 0.44; P = 0.14). Conclusion: LI-IHE seems to lower SBP, DBP, and MAP values in prehypertensive and hypertensive adults. It appears that LI-IHE reduces, in greater magnitude, blood pressure levels in hypertensive patients, specifically in patients aged <45 years, those who are overweight, and those on medications. Nevertheless, substantial heterogeneity in the main results and in the analyses by subgroups generated uncertainty about the real reduction magnitude that LI-IHE can produce on blood pressure.

Labetalol in Hypertensive Patients with Angina Pectoris: Beneficial Effect of Combined α- and β-Adrenoreceptor Blockade

1978 ◽  
Vol 55 (s4) ◽  
pp. 283s-286s
Author(s):  
W. F. Lubbe ◽  
D. A. White
Keyword(s):  
Blood Pressure ◽  
Angina Pectoris ◽  
Isometric Exercise ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Hypertensive Patients ◽  
Isotonic Exercise ◽  
Final Treatment ◽  
Stepwise Reduction ◽  
Blood Pressures

1. Eight hypertensive patients with angina pectoris had placebo added to their existing medications for 8 weeks, then incremental doses of active labetalol with simultaneous stepwise reduction in other medicines until blood pressure was satisfactorily controlled; after that only labetalol and thiazide (8 weeks) and finally labetalol-placebo together with previous β-adrenoreceptor antagonists and thiazide for 4 weeks were administered. 2. During the labetalol plus thiazide period resting blood pressures and measurements obtained during isotonic exercise, isometric exercise and the cold pressor test were significantly lower than during the initial placebo addition period. Angina scores were significantly reduced during this period. 3. During the final treatment with placebo, β-adrenoreceptor antagonist and thiazide, blood pressures remained reduced, but angina was significantly worse. 4. Labetalol which antagonizes both α- and β-adrenoreceptors produced better relief of angina pectoris than β-adrenoreceptor antagonists during improvement in blood pressure in hypertensive patients.

Ambulant Blood Pressure: Reproducibility and the Assessment of Interventions

1980 ◽  
Vol 59 (6) ◽  
pp. 497-500 ◽  
Author(s):  
S. Mann ◽  
M. W. Millar Craig ◽  
V. Balasubramanian ◽  
P. M. M. Cashman ◽  
E. B. Raftery
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Single Dose ◽  
Diastolic Blood Pressure ◽  
Therapeutic Interventions ◽  
Daily Routine ◽  
Hypertensive Patients ◽  
Mean Values ◽  
Arterial Blood ◽  
Reliable Assessment

1. We have assessed the day-to-day reproducibility of intra-arterial blood pressure by monitoring 17 freely ambulant hypertensive patients for a period of 48 h. Eight had no change of therapeutic regimen throughout and nine took a single dose of a hypotensive agent before retiring on the second night. 2. Records were analysed to provide hourly mean values of heart rate, systolic and diastolic blood pressure. No significant differences between first and second day recordings were found except after the intervention in the second group. 3. Allowing subjects to follow their normal daily routine produces inevitable variation in their pattern of physical and other activity. However, by the use of these methods of recording and analysis, with pooled measurements from a small group of subjects, reproducibility is sufficiently good to permit the reliable assessment of therapeutic interventions.

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