CORONARY PLAQUE INSTABILITY SYNCHRONIZES WITH INFLAMMATORY ACTIVITY OF MULTIPLE ORGANS INCLUDING CAROTID PLAQUES AND VISCERAL ADIPOSE TISSUE

Abstract Background Dysfunctional Visceral adipose tissue (VAT) secretes pro-inflammatory cytokines and promotes inflammatory cell infiltration into VAT thereby boosting insulin resistance and systemic inflammation which eventually lead to increased risk of cardiovascular disease (CVD). F-18 FDG PET/CT is well known to reflect the inflammatory activity of classically activated (M1) macrophage. Purpose We hypothesized that F-18 FDG PET/CT could reflect the inflammatory activity of dysfunctional VAT and carotid artery which were associated with coronary plaque instability. Methods A total of 90 participants were enrolled in this prospective study. F-18 FDG PET/CT was performed in 32 participants with acute myocardial infarction (AMI) within a week of disease onset, 33 participants with stable coronary artery disease (CAD), and 25 control subjects. Maximum standardized uptake value (SUVmax) was calculated in VAT, subcutaneous adipose tissue (SAT), spleen, and bone marrow (BM). Target-to-background ratio (TBR) was calculated in right carotid artery and right jugular vein. Results The SUVmax of VAT and the TBR of right carotid artery were highest in patients with AMI, intermediate in patient with stable CAD, and lowest in control subjects. Systemic inflammation surrogate markers such as high-sensitivity C-reactive protein, spleen SUVmax were also showed similar pattern like the SUVmax of VAT and the TBR of right carotid artery. Furthermore, multiple linear regression analysis showed that the SUVmax of VAT and spleen SUVmax were independently associated with the TBR of right carotid artery. Conclusions F-18 FDG PET/CT could reflect the synchronized systemic inflammation in VAT and carotid artery which could affect the coronary artery instability. Furthermore, our findings offer clinical insights into risk stratification, monitoring of therapy, and physiological changes in the development of CAD. Funding Acknowledgement Type of funding source: None

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CAROTID PLAQUE INFLAMMATION IS ASSOCIATED WITH INFLAMMATORY ACTIVITY OF VISCERAL ADIPOSE TISSUE

Journal of Hypertension ◽

10.1097/01.hjh.0000573392.22188.d6 ◽

2019 ◽

Vol 37 ◽

pp. e266

Author(s):

K. Pahk ◽

H.R. Kwon ◽

H.Y. Cho ◽

H.W. Kwon ◽

J.S. Eo ◽

...

Keyword(s):

Adipose Tissue ◽

Visceral Adipose Tissue ◽

Carotid Plaque ◽

Inflammatory Activity ◽

Plaque Inflammation ◽

Visceral Adipose

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EXERCISE TRAINING COULD REDUCE INFLAMMATORY ACTIVITY OF VISCERAL ADIPOSE TISSUE IN OVERWEIGHT WOMEN

Journal of Hypertension ◽

10.1097/01.hjh.0000573940.24248.d3 ◽

2019 ◽

Vol 37 ◽

pp. e316

Author(s):

K. Pahk ◽

H.R. Kwon ◽

H.Y. Cho ◽

H.W. Kwon ◽

J.S. Eo ◽

...

Keyword(s):

Adipose Tissue ◽

Exercise Training ◽

Visceral Adipose Tissue ◽

Inflammatory Activity ◽

Overweight Women ◽

Visceral Adipose

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Exercise Training Could Reduce Inflammatory Activity Of Visceral Adipose Tissue In Overweight Women

Atherosclerosis ◽

10.1016/j.atherosclerosis.2019.06.411 ◽

2019 ◽

Vol 287 ◽

pp. e139

Author(s):

K. Pahk ◽

H.Y. Cho ◽

H.R. Kwon ◽

S. Choi ◽

H.W. Kwon ◽

...

Keyword(s):

Adipose Tissue ◽

Exercise Training ◽

Visceral Adipose Tissue ◽

Inflammatory Activity ◽

Overweight Women ◽

Visceral Adipose

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Abstract P405: Visceral Adipose Tissue Volume is Associated With Prevalent Coronary Plaque Independent of Total Adiposity in Psoriasis

Circulation ◽

10.1161/circ.141.suppl_1.p405 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Domingo E Uceda ◽

Aarthi Reddy ◽

Harry Choi ◽

Sundus S Lateef ◽

Khaled M Abdelrahman ◽

...

Keyword(s):

Risk Factors ◽

Adipose Tissue ◽

Visceral Adipose Tissue ◽

Pubic Symphysis ◽

Coronary Plaque ◽

High Risk Population ◽

Framingham Risk ◽

Increased Risk ◽

Chronic Inflammatory Condition ◽

Visceral Adipose

Introduction: Psoriasis (PSO) is a chronic inflammatory condition associated with accelerated atherosclerosis and increased risk of myocardial infarction in part mediated through high visceral adipose tissue (VAT) volume. VAT has been shown to be associated with increased coronary burden; however, the relationship with prevalent coronary plaque in PSO has not been explored. Hypothesis: We hypothesized that VAT would associate with coronary plaque in PSO beyond traditional risk factors. Methods: A total of 164 consecutive PSO patients underwent coronary computed tomography angiography (CCTA) as part of a large cohort study to assess presence of coronary plaque. Low-dose CT was utilized to quantify VAT and subcutaneous adipose tissue (SAT) volume from the level of the diaphragm to the pubic symphysis. Logistic regression was used to assess the association between the presence of coronary plaque and the ratio of VAT-to-total adiposity in adjusted models (STATA 12). Results: The cohort was middle-aged, predominantly male, relatively low CV risk by FRS and mild to moderate PSO (Table 1). Patients with increased VAT-to-total adiposity, had significantly increased coronary plaque presence (70% (45 of 65) vs. 31% (31 of 99), p<0.001) compared to those with low VAT-to-total adiposity. Moreover, increased VAT-to-total adiposity was associated with 3-fold higher odds of having a prevalent coronary plaque (adjusted OR 2.96 (1.22 - 7.22), p=0.016) after adjustment for Framingham risk score, body-mass-index, waist-to-hip ratio and lipid treatment. Conclusions: Having higher VAT was associated with higher prevalence of coronary plaque independent of total adiposity and cardiovascular risk factors. These findings suggest VAT contributes to coronary plaque in psoriasis and that weight loss efforts may improve outcomes in this high-risk population.

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