Oxygen treatment restores energy status following experimental neonatal hypoxia-ischemia

2007 ◽  
Vol 8 (2) ◽  
pp. 165-173 ◽  
Author(s):  
John W. Calvert ◽  
John H. Zhang
Keyword(s):  
Energy Status ◽  
Neonatal Hypoxia ◽  
Oxygen Treatment ◽  
Hypoxia Ischemia

Oxygen treatment after perinatal hypoxia-ischemia reduces neuronal damage at short survival times, but worsens injury with long-term survival

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S444-S444 ◽  
Author(s):  
Kristin M Noppens ◽  
J Regino Perez-Polo ◽  
David K Rassin ◽  
Karin N Westlund ◽  
Roderic Fabian ◽  
...  
Keyword(s):  
Neuronal Damage ◽  
Perinatal Hypoxia ◽  
Survival Times ◽  
Term Survival ◽  
Long Term Survival ◽  
Short Survival ◽  
Oxygen Treatment ◽  
Hypoxia Ischemia

scholarly journals Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

Autophagy ◽  
2010 ◽  
Vol 6 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Silvia Carloni ◽  
Silvia Girelli ◽  
Claudia Scopa ◽  
Giuseppe Buonocore ◽  
Mariangela Longini ◽  
...  
Keyword(s):  
Neuroprotective Effect ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

scholarly journals The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin

2004 ◽  
Vol 91 (4) ◽  
pp. 900-910 ◽  
Author(s):  
Xiaoyang Wang ◽  
Changlian Zhu ◽  
Xinhua Wang ◽  
Jens Gammeltoft Gerwien ◽  
Andre Schrattenholz ◽  
...  
Keyword(s):  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

scholarly journals Splenic Immune Cells in Experimental Neonatal Hypoxia–Ischemia

2012 ◽  
Vol 4 (2) ◽  
pp. 208-219 ◽  
Author(s):  
Nancy Fathali ◽  
Robert P. Ostrowski ◽  
Yu Hasegawa ◽  
Tim Lekic ◽  
Jiping Tang ◽  
...  
Keyword(s):  
Immune Cells ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

Neonatal hypoxia-ischemia caused mild motor dysfunction, recovered by acrobatic training, without affecting morphological structures involved in motor control in rats

2019 ◽  
Vol 1707 ◽  
pp. 27-44 ◽  
Author(s):  
Heloísa Deola Confortim ◽  
Bruna Ferrary Deniz ◽  
Wellington de Almeida ◽  
Patrícia Maidana Miguel ◽  
Loise Bronauth ◽  
...  
Keyword(s):  
Motor Control ◽  
Motor Dysfunction ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

Experimental neonatal hypoxia ischemia causes long lasting changes of oxidative stress parameters in the hippocampus and the spleen

2018 ◽  
Vol 46 (4) ◽  
pp. 433-439 ◽  
Author(s):  
Felipe Kawa Odorcyk ◽  
Janaína Kolling ◽  
Eduardo Farias Sanches ◽  
Angela T.S. Wyse ◽  
Carlos Alexandre Netto
Keyword(s):  
Oxidative Stress ◽  
Wistar Rat ◽  
Mortality And Morbidity ◽  
Neonatal Hypoxia ◽  
Oxidative Stress Parameters ◽  
Rat Pups ◽  
Hypoxia Ischemia ◽  
Anti Oxidant ◽  
Enzyme Superoxide Dismutase ◽  
Stress Parameters

Abstract Neonatal hypoxia ischemia (HI) is the main cause of mortality and morbidity in newborns. The mechanisms involved in its progression start immediately and persist for several days. Oxidative stress and inflammation are determinant factors of the severity of the final lesion. The spleen plays a major part in the inflammatory response to HI. This study assessed the temporal progression of HI-induced alterations in oxidative stress parameters in the hippocampus, the most affected brain structure, and in the spleen. HI was induced in Wistar rat pups in post-natal day 7. Production of reactive oxygen species (ROS), and the activity of the anti oxidant enzyme superoxide dismutase and catalase were assessed 24 h, 96 h and 38 days post-HI. Interestingly, both structures showed a similar pattern, with few alterations in the production of ROS species up to 96 h often combined with an increased activity of the anti oxidant enzymes. However, 38 days after the injury, ROS were at the highest in both structures, coupled with a decrease in the activity of the enzymes. Altogether, present results suggest that HI causes long lasting alterations in the hippocampus as well as in the spleen, suggesting a possible target for delayed treatments for HI.

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