Correction of Warfarin-Induced Nasal Hypoplasia

2003 ◽  
Vol 111 (5) ◽  
pp. 1680-1687 ◽  
Author(s):  
James P. Bradley ◽  
Henry K. Kawamoto ◽  
Peter Taub
Keyword(s):  
Nasal Hypoplasia

scholarly journals Fetal Warfarin Syndrome – a case report

2022 ◽  
Vol 9 (1) ◽  
pp. 82-84
Author(s):  
Syed Sajid Hussain Shah ◽  
Bibi Aaliya
Keyword(s):  
Cardiac Surgery ◽  
Case Report ◽  
Family Planning ◽  
Plastic Surgery ◽  
Valve Replacement ◽  
Male Infant ◽  
Provisional Diagnosis ◽  
Initial Management ◽  
History Of ◽  
Nasal Hypoplasia

A two-month-old male infant presented with history of respiratory difficulty and got admitted with provisional diagnosis of pneumonia. On examination patient was having unilateral nasal hypoplasia and cyanosis with echocardiography showing truncus arteriosus. Detail history revealed that mother had valve replacement and she was taking warfarin during pregnancy. After initial management patient was referred to pediatric cardiac surgery and plastic surgery for further management. Parents were counseled regarding contraception and family planning.  

Nasal hypoplasia without Down syndrome

2003 ◽  
Vol 29 (5) ◽  
pp. S221-S222
Author(s):  
M.A. Carroll ◽  
J.M. Mastrobattista ◽  
A.M. Glaser ◽  
M.A. Hamrick ◽  
M. Monga
Keyword(s):  
Down Syndrome ◽  
Nasal Hypoplasia

Foetal Warfarin Syndrome—a complex airway problem

1992 ◽  
Vol 106 (12) ◽  
pp. 1098-1099 ◽  
Author(s):  
J. D. T. Mason ◽  
A. Jardine ◽  
K. P. Gibbin
Keyword(s):  
Cardiac Surgery ◽  
First Trimester ◽  
Thromboembolic Disease ◽  
Feeding Problems ◽  
Feeding Difficulties ◽  
Child Bearing ◽  
Airway Problem ◽  
Trimester Exposure ◽  
Nasal Hypoplasia

AbstractPremature cartilaginous calcification and nasal hypoplasia following first trimester exposure to warfarin are known as the Foetal Warfarin Syndrome (FWS). There are over 40 cases reported in the literature, many of which describe breathing and feeding difficulties in the first few months of life. We report a case where a child had had difficulties breathing and feeding in the first months of life. These had been attributed to nasal hypoplasia. After proper ENT assessment the child benefitted from adenoidectomy.ENT surgeons should be aware of the syndrome as more women of child bearing age are taking warfarin following cardiac surgery and treatment of thromboembolic disease. ENT surgeons may be asked to review these children who often present with airway and feeding problems which have been attributed to nasal hypoplasia.

scholarly journals Vitamin K Deficiency Embryopathy from Hyperemesis Gravidarum

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Andrew S. Lane ◽  
Jennifer L. Stallworth ◽  
Kacey Y. Eichelberger ◽  
Kenneth F. Trofatter
Keyword(s):  
Vitamin K ◽  
Enteral Feeding ◽  
Hyperemesis Gravidarum ◽  
Severe Form ◽  
Common Condition ◽  
Vitamin K Deficiency ◽  
Facial Profile ◽  
Prepregnancy Weight ◽  
K Deficiency ◽  
Nasal Hypoplasia

A 21-year-old primigravida had a pregnancy complicated by hyperemesis gravidarum (HG) beginning at 7-week gestation. Despite medical therapy, she lost 18% of her prepregnancy weight. Early ultrasound at 14 weeks demonstrated a flattened facial profile with nasal hypoplasia (Binder phenotype) consistent with vitamin K deficiency from HG. She had a percutaneous endoscopic gastrojejunostomy tube placed for enteral feeding at 15-week gestation. At repeated anatomy ultrasound at 21-week gestation, delivery, and postnatal pediatric genetics exam, nasal hypoplasia was consistent with vitamin K deficiency embryopathy from HG. Nausea and vomiting of pregnancy is a common condition. HG, the most severe form, has many maternal and fetal effects. Evaluation of vitamin K status could potentially prevent this rare and disfiguring embryopathy.

scholarly journals A case of acrodysostosis: a rare primary bone dysplasia

2018 ◽  
Vol 6 (6) ◽  
pp. 2165
Author(s):  
Roopal Vasava ◽  
Bhargav Tank ◽  
Abhilasha Jain
Keyword(s):  
Case Report ◽  
Rare Disease ◽  
Skeletal Dysplasia ◽  
Bone Dysplasia ◽  
Female Child ◽  
Facial Dysmorphism ◽  
Radiological Features ◽  
Primary Bone ◽  
Hands And Feet ◽  
Nasal Hypoplasia

Acrodysostosis is a rare skeletal dysplasia characterized by brachydactyly, facial dysostosis and nasal hypoplasia. Diagnostic approach to this disorder is based on clinical, radiological and hormonal assays. We present a case of 11-year-old female child who presented with the complaint of short stubby hands and feet since birth and facial dysmorphism. Her skeletal survey revealed typical radiographic features of acrodysostosis. Hormonal assays did not reveal any significant abnormality. In this case report, we would like to highlight the clinical and radiological features of this disorder which could be helpful in diagnosis of this rare disease.

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