Sleep Deprivation Affects Thermal Pain Thresholds but Not Somatosensory Thresholds in Healthy Volunteers

SummaryModafinil is a new psychotropic compound with central α1, adrenergic-stimulant activity in animals. In the present study, its pharmacological activity in man was evaluated in the sleep-deprivation induced psychomotor and cognitive impairment paradigm. This was a double-blind placebo-controlled study involving 12 healthy volunteers. Standard psychomotor and memory tasks were used, including critical flicker fusion frequency determination (CFF), choice reaction time and short- and long-term memory evaluation. Results revealed a clear antagonism by modafinil of the psychomotor and cognitive impairment induced by sleep-deprivation in most tasks 6 h after drug administration, and marginal effects 18 h after. These results therefore support a psychostimulant activity of modafinil in man.

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Hypnosis increases heat detection and heat pain thresholds in healthy volunteers☆

Regional Anesthesia and Pain Medicine ◽

10.1053/rapm.2002.29126 ◽

2002 ◽

Vol 27 (1) ◽

pp. 43-46 ◽

Cited By ~ 1

Author(s):

A LANGLADE ◽

C JUSSIAU ◽

L LAMONERIE ◽

E MARRET ◽

F BONNET

Keyword(s):

Healthy Volunteers ◽

Heat Pain ◽

Pain Thresholds

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Cervical lateral glide increases nociceptive flexion reflex threshold but not pressure or thermal pain thresholds in chronic whiplash associated disorders: A pilot randomised controlled trial

Manual Therapy ◽

10.1016/j.math.2009.09.004 ◽

2010 ◽

Vol 15 (2) ◽

pp. 149-153 ◽

Cited By ~ 51

Author(s):

Michele Sterling ◽

Ashley Pedler ◽

Cliffton Chan ◽

Madonna Puglisi ◽

Viana Vuvan ◽

...

Keyword(s):

Randomised Controlled Trial ◽

Controlled Trial ◽

Pilot Randomised Controlled Trial ◽

Pain Thresholds ◽

Thermal Pain ◽

Nociceptive Flexion Reflex ◽

Reflex Threshold ◽

Whiplash Associated Disorders ◽

Randomised Controlled ◽

Chronic Whiplash

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Effects of different sleep deprivation protocols on sleep perception in healthy volunteers

Sleep Medicine ◽

10.1016/j.sleep.2014.05.025 ◽

2014 ◽

Vol 15 (10) ◽

pp. 1219-1224 ◽

Cited By ~ 9

Author(s):

Leonardo I. Goulart ◽

Luciano R. Pinto ◽

Michael L. Perlis ◽

Raquel Martins ◽

Luis Otavio Caboclo ◽

...

Keyword(s):

Sleep Deprivation ◽

Healthy Volunteers

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Adaptation of thermal pain in the skin

Journal of Applied Physiology ◽

10.1152/jappl.1962.17.4.693 ◽

1962 ◽

Vol 17 (4) ◽

pp. 693-696 ◽

Cited By ~ 23

Author(s):

Leon C. Greene ◽

James D. Hardy

Keyword(s):

Thermal Radiation ◽

Skin Temperature ◽

Radiation Intensity ◽

Pain Threshold ◽

Human Subjects ◽

Initial Period ◽

Pain Thresholds ◽

Thermal Pain ◽

Cutaneous Pain ◽

The Subject

Cutaneous pain thresholds were determined on blackened skin of foreheads and forearms of human subjects over areas of 16 cm2 by recording skin temperature during exposure to thermal radiation for periods up to 50 min. Intensity of stimulus was controlled by the subject so that threshold pain was maintained throughout the exposure. After the initial period of adjustment by the subject, radiation intensity was generally maintained constant although skin temperature for the pain threshold decreased from 44.9 C to 43.8 C. By using an intensity as low as 22 mcal/cm2/sec, threshold pain was evoked in 29 min at a skin temperature of 42.2 C. In both groups, once pain had been established it did not disappear. It is inferred from these observations that thermal pain does not adapt for near-threshold stimulation in the period between onset of pain at 30 sec and termination of stimulation. Submitted on December 26, 1961

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