scholarly journals LIVER DENDRITIC CELLS RESIST THE EFFECTS OF RETINOIC ACID AND TRANSFORMING GROWTH FACTOR-B FOR THE INDUCTION OF FOXP3+ REGULATORY T CELLS

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 488
Author(s):  
A Thomson ◽  
D Tokita ◽  
C S. Gandhi ◽  
T Sumpter
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Factor B

P158 All-trans retinoic acid and rapamycin synergize with transforming growth factor-B to induce regulatory T cells but confer distinct in vivo migratory capacities

Cytokine ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 570
Author(s):  
G. Raimondi ◽  
S. Jhunjhunwala ◽  
E. Nichols ◽  
A. Thomson ◽  
S. Little
Keyword(s):  
T Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Factor B ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Oral tolerance: is it all retinoic acid?

2007 ◽  
Vol 204 (8) ◽  
pp. 1737-1739 ◽  
Author(s):  
Harald von Boehmer
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Vitamin A ◽  
Oral Tolerance ◽  
Transforming Growth Factor ◽  
Tolerance Mechanisms ◽  
Cell Homing ◽  
Naïve T Cells

Oral tolerance has been argued to depend on “special” presentation of antigen in the gut. New studies support this idea by showing that the catalysis of vitamin A into retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor (TGF)-β–dependent conversion of naive T cells into regulatory T (T reg) cells and also directs T reg cell homing to the gut. These results reveal new tolerance mechanisms that will aid the use of T reg cells in the clinic.

scholarly journals Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines

2009 ◽  
Vol 206 (10) ◽  
pp. 2131-2139 ◽  
Author(s):  
Jens Nolting ◽  
Carolin Daniel ◽  
Sabine Reuter ◽  
Christina Stuelten ◽  
Peng Li ◽  
...  
Keyword(s):  
T Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Th17 Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Partial Explanation ◽  
Cell Conversion ◽  
Smad3 Expression

It has been reported that retinoic acid (RA) enhances regulatory T (T reg) cell conversion by inhibiting the secretion of cytokines that interfere with conversion. This report shows that these conclusions provide a partial explanation at best. First, RA not only interfered with cytokine secretion but also with the ability of these cytokines to inhibit T reg cell conversion of naive T cells. Furthermore, RA enhanced conversion even in the absence of inhibitory cytokines. The latter effect depended on the RA receptor α (RARα) but did not require Smad3, despite the fact that RA enhanced Smad3 expression. The RARα1 isoform was not essential for RA-dependent enhancement of transforming growth factor β–driven conversion, suggesting that conversion can also be mediated by RARα2. Interleukin (IL)-6 strongly reduced RARα expression levels such that a deficiency of the predominant RARα1 isoform leaves too little RARα2 for RA to inhibit the generation of Th17 cells in the presence of IL-6.

scholarly journals All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities

2013 ◽  
Vol 94 (5) ◽  
pp. 981-989 ◽  
Author(s):  
Siddharth Jhunjhunwala ◽  
Leo C. Chen ◽  
Erin E. Nichols ◽  
Angus W. Thomson ◽  
Giorgio Raimondi ◽  
...  
Keyword(s):  
T Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Transforming Growth Factor-β and All-Trans Retinoic Acid Generate Ex Vivo Transgenic Regulatory T Cells With Intestinal Homing Receptors

2009 ◽  
Vol 41 (6) ◽  
pp. 2670-2672 ◽  
Author(s):  
C. Moore ◽  
D. Sauma ◽  
J. Morales ◽  
M.R. Bono ◽  
M. Rosemblatt ◽  
...  
Keyword(s):  
T Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Ex Vivo ◽  
Transforming Growth Factor Β ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

2011 ◽  
Vol 141 (5) ◽  
pp. 1802-1812 ◽  
Author(s):  
John J. Worthington ◽  
Beata I. Czajkowska ◽  
Andrew C. Melton ◽  
Mark A. Travis
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

scholarly journals Regulatory T-Cells Protect From Type 1 Diabetes After Induction by Coxsackievirus Infection in the Context of Transforming Growth Factor- 

Diabetes ◽  
2008 ◽  
Vol 57 (5) ◽  
pp. 1302-1311 ◽  
Author(s):  
M. J. Richer ◽  
N. Straka ◽  
D. Fang ◽  
I. Shanina ◽  
M. S. Horwitz
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor
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